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| Number | Title | Issue Date |
| 8058228 | Leptin peptide antagonists Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby ... | 11/15/2011 |
| 7968527 | Inhibition of FGF signaling Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhi... | 06/28/2011 |
| 7906626 | Immunological control of β-amyloid levels in vivo Disclosed are bispecific antibodies comprising a first antibody binding specificity which confers the ability of the bispecific antibody to cross the blood-brain barrier, and a second antibody specificity conferring the ability of the bispecific antibody to bind to ... | 03/15/2011 |
| 7749966 | Immunological modulation of insulin-like growth factor 1 for cancer prevention/treatment and prolonging longevity Provided is a simple and safe immunization procedure to reduce cancer incidence and increase longevity by modulating IGF-1 levels in the body. Described are cancer preventive vaccines and methods that elicit circulating antibodies specific to insulin-like growth fac... | 07/06/2010 |
| 7709216 | Methods for preventing or reducing ischemia/reperfusion induced myocardial cell death Provided herein are methods relating to inhibition of PUMA function for preventing or reducing myocardial cell death. A method for preventing or reducing ischemia/reperfusion induced myocardial cell death in a human is provided as are methods for identifying pharmac... | 05/04/2010 |
| 7612043 | Method of reducing or inhibiting ObR signaling using a leptin antagonist consisting of SEQ id No: 2 Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby ... | 11/03/2009 |
| 7553832 | Methods and compositions for specific inhibition of protein splicing by small molecules The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the inhibition of protein autosplicing of intein-containing proteins. Additionall... | 06/30/2009 |
| 7462472 | Methods and compositions relating to anthrax pathogenesis The structures of Edema Factor alone and Edema Factor bound to calmodulin without substrate has been crystallized and its structure determined by x-ray crystallography. Based upon these crystal structures, a method assaying for inhibitors of infection by a bacteria ... | 12/09/2008 |
| 7413884 | Immunological control of β-amyloid levels in vivo Disclosed are antibodies which catalyze hydrolysis of β-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using β-amyloid peptides which incorporate transition state analogs are also ... | 08/19/2008 |
| 7407929 | Leptin peptide antagonists Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby ... | 08/05/2008 |
| 6872554 | Immunological control of β-amyloid levels in vivo Disclosed are bispecific antibodies comprising a first antibody binding specificity which confers the ability of the bispecific antibody to cross the blood-brain barrier, and a second antibody specificity conferring the ability of the bispecific antibody to bind to ... | 03/29/2005 |
| 6582945 | Immunological control of ଲ-amyloid levels in vivo Disclosed are antibodies which catalyze hydrolysis of ଲ-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using ଲ-amyloid peptides which incorporate transition st... | 06/24/2003 |
| 6140091 | Anti-idiotype vaccines to elicit catalytic antibodies Disclosed are methods for the production of second generation catalytic antibodies. The disclosed methods offer a variety of advantages relative to prior art techniques. For example, the methods of the present invention do not require prior identification... | 10/31/2000 |
