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| Number | Title | Issue Date |
| 5965424 | Methods for making neisseria or hemophilus IgA protease and DNA encoding the proteases The present invention concerns a process for the isolation of recombinant IgA protease from inclusion bodies. In addition a recombinant DNA is claimed which codes for an IgA protease whose C-terminal helper sequence and preferably also its N-terminal sign... | 10/12/1999 |
| 5851840 | Biotinsilane compounds and a binding matrix containing these compounds The invention concerns a binding matrix containing a carrier material with an oxidic surface and a solid phase reactant covalently bound thereto via anchor groups which is capable of binding to at least one free reaction partner, which is characterized in... | 12/22/1998 |
| 5792606 | Nucleic acid hybridization based assay for determining a substance of interest The application describes homogeneous assays for determining ligands. A sample is contacted with a labeled substance P2 and receptor R. The receptor R consists of one molecule of P1, which monovalently and specifically binds to P | 08/11/1998 |
| 5780260 | Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an immobilized enzyme having a specific volume activity of at ... | 07/14/1998 |
| 5776702 | Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is bound, a reaction vessel is used as the solid phase on the inne... | 07/07/1998 |
| 5770685 | Photolabile polymers with triazenedor/and pentazadiene building blocks The invention concerns the use of triazene or/and pentazadiene polymers as photoresists and in particular as positive photoresists in order to cover biochemical reagents. In addition the invention concerns a new process for the production of triazene or/a... | 06/23/1998 |
| 5654163 | Indophenol substituted maltooligosides as -amylase substrates The invention concerns new indophenyl-substituted maltose derivatives, their use for the determination of the enzymatic activity of -amylase and reagents for the determination of -amylase which contain the new indophenyl-substituted maltose ... | 08/05/1997 |
| 5632993 | Immunogens and the use thereof for obtaining antibodies against HbA1c The present invention provides immunogens for obtaining HbA1c -specific antibodies, which immunogens have the general formula: ##STR1## wherein M is 1 to 40, T is a carrier protein and A is a spacer which has a chain length of 10 to 20 ato... | 05/27/1997 |
| 5618927 | Process for the reactivation of denatured protein The invention concerns a process for the reactivation of denatured protein, in which the protein is incubated with a solution of Tris base or/and a salt of Tris at a concentration of at least 400 mmol/l and at a pH at which the protein to be treated can t... | 04/08/1997 |
| 5614367 | Diagnostic test using chimeric antibodies Chimeric monoclonal antibodies or fragments thereof are used according to the present invention in diagnostic tests for the quantitative immunological determination of substances in the blood or serum of patients. For the diagnostic detection of substance... | 03/25/1997 |
| 5614394 | Method and monoclonal antibodies for vitamin B12 determination A method for making an monoclonal antibody specific for vitamin B12 by immunizing mice with vitamin B12-b-acid and isolating hybridomas that produce monoclonal antibodies which have an affinity constant for B12 greater than 5×109 l/mol is disc... | 03/25/1997 |
| 5610280 | Monoclonal antibodies against melanoma The present invention provides a human monoclonal antibody against melanoma, characterized in that it binds to the gangliosides GM3 and GD3 but essentially does not bind to the gangliosides GM1, GM2, GD1a, GD1b and GD2, the binding of the antibody to the ... | 03/11/1997 |
| 5593865 | Process for the activating of gene-technologically produced, heterologous, disulphide bridge-containing eukaryotic proteins after expression in prokaryotes A process for the activation of disulphide linked recombinant proteins expressed in prokaryotes is described. The process includes cell digestion, solubilization under denaturing and reducing conditions and activation under oxidizing conditions in the pre... | 01/14/1997 |
| 5576219 | Standard solutions for determination of thyroxine-binding capacity in serum The present invention provides a process for the determination of the thyroxine-binding capacity in serum, wherein, for the calibration, there are used at least two different standard solutions which contain substantially the same amount of thyroxine-bind... | 11/19/1996 |
| 5573918 | Process and reagent for specific determination of pancreatic alpha amylase The present invention provides a process for the specific determination of pancreatic alpha-amylase in the presence of salivary alpha-amylase in body fluids, especially in serum, plasma, duodenal juice or urine, by reaction with a system for the detection... | 11/12/1996 |
| 5532172 | Process and reagent for the determination of low density lipoproteins (LDL) The present invention provides a process for the determination of low density lipoproteins (LDL) in body fluids, wherein high density lipoprotein (HDL) antibodies are added to a sample to be investigated, insolubles formed are separated off and the LDL or... | 07/02/1996 |
| 5480790 | Water-soluble proteins modified by saccharides A water-soluble protein conjugate modified by saccharides is covalently bound to a carbohydrate backbone via a saccharide group. Such protein conjugates modified by saccharides can be produced in a simple way by polymerizing a vinylsaccharide and conjugat... | 01/02/1996 |
| 5473058 | Process and reagent for the specific determination of pancreatic -amylase The present invention provides a process for the specific determination of pancreatic -amylase in the presence of salivary -amylase in body fluids by reaction with a system for the detection of -amylase with the use of an inhibitor fo... | 12/05/1995 |
| 5460944 | Storable protein solution The present invention provides a storable POD conjugate solution, characterised by a pH value of 5.0 to 6.5, adjusted by means of an organic buffer substance with a concentration of 40 to 100 mmol/l, and 0.05 to 1.0 mol/l magnesium aspartate.... | 10/24/1995 |
| 5455157 | Method for the non-radioactive measurement of the nucleic acid synthesis in eukaryotic cells For the determination of the rate of nucleic acid synthesis in eukaryotic cells a nucleotide which is non-radioactively labelled or derivatized with a hapten is introduced into the cells with the addition of liposomes and the rate of synthesis of the nucl... | 10/03/1995 |
| 5453363 | Process for the activation of t-PA or Ing after genetic expression in prokaryotes A process for the activation of t-PA or IgG after expression in prokaryotes is described. The process includes cell digestion, solubilization under denaturing and reducing conditions and activation under oxidizing conditions in the presence of GSH/GSSG.... | 09/26/1995 |
| 5451508 | Method and monoclonal antibodies for vitamin B12 determination For the determination of vitamin B12 a sample solution is incubated with at least two receptors R1 and R2 of which R1 mediates the binding to the solid phase and R2 is labelled, whereby a receptor is used as one... | 09/19/1995 |
| 5441869 | Method for the determination of fibrin The present invention concerns an improved method for the determination of fibrin in body fluids in which before the actual determination the sample solution containing fibrin is incubated in the presence of thiocyanate, iodide, magnesium or/and guanidini... | 08/15/1995 |
| 5437981 | Method for the immunological determination of ligands Method for the immunological determination of a ligand in which the ligand to be determined is reacted with a) at least 2 molecules of a specifically bindable substance P2 of which at least one of these molecules carries a label and b) a receptor R which consi... | 08/01/1995 |
| 5434067 | Process for the production and renaturation of recombinant, biologically active, eukaryotic alkaline phosphatase In a process for the production of recombinant, biologically active, eukaryotic alkaline phosphatase a DNA sequence coding for a eukaryotic alkaline phosphatase is expressed in a prokaryotic host cell and the expression product is obtained in an active fo... | 07/18/1995 |
| 5409699 | Compositions containing glycosylated molecules having human tissue type plasminogen activator enzymatic activity The invention is a pharmaceutical composition containing a glycosylated protein having human tissue type plasminogen activator activity of at least 1.4 MU/ml, citrate, and at least one of a number of various compounds. The composition has a pH ranging fro... | 04/25/1995 |
| 5407836 | Process and reagent for the determination of low density lipoproteins (LDL) The present invention provides a process for the determination of low density lipoproteins (LDL) in body fluids, wherein high density lipoprotein (HDL) antibodies are added to a sample to be investigated, insolubles formed are separated off and the LDL or... | 04/18/1995 |
| 5376557 | Process for the determination of antibodies which are class-specific for an antigen and a reagent for carrying out the process The present invention provides a method for type determination in body fluids of antibodies of a definite immunoglobulin class which are directed against an antigen A according to the immunoassay principle by incubation of the sample solution with at leas... | 12/27/1994 |
| 5366730 | Stabilized compositions having human tissue type plasminogen activator enzymatic activity Pharmaceutical preparation of a protein with t-PA activity with an enzymatic activity of at least 0.25 MU/ml. and a pH value of 4.5 to 9 which contains a substance of the group citric acid, ascorbic acid, 2-oxoglutaric acid, fumaric acid, Tris and EDTA in... | 11/22/1994 |
| 5362655 | Process for the determination of a specifically bindable substance For the determination of a specifically bindable substance by incubation of the sample solution with at least two receptors R1 and R2, whereby R1 and R2 are capable of binding to each other and R1 is ... | 11/08/1994 |
| 5352452 | Stabilized compositions containing non-glysylated human tissue type plasminogen activator derivative K2P pro Stabilized compositions containing a non-glycosylated human tissue type plasminogen activator derivative are disclosed. The derivative is referred to as K2P pro. The composition has enzymatic activity of at least 1.1 mU/ml, a pH of from 4.5 to 6.5, and co... | 10/04/1994 |
| 5352453 | Compositions containing non-glycosylated human tissue type plasminogen activator Pharmaceutical compositions containing non-glycosylated human tissue type plasminogen activator (t-PA) having enzymatic activity of at least 0.1 MU/ml are disclosed. The compositions have a pH of from 4.5 to 6, contain citrate, and at least one other comp... | 10/04/1994 |
| 5344757 | Process for the detection of nucleic acids For the detection of nucleic acids of definite sequence by hybridisation with a complementary nucleic acid probe which contains bound via a chemical bonding at least one hapten as labelling one uses, as hapten, a steroid which is bound via a bridge of at ... | 09/06/1994 |
| 5342788 | Method and standard solution for the determination of thyroxine (T4) or triiodothyronine (T3) A standard solution containing thyroxine-binding globulin (TBG) and thyroxine or triiodothyronine dissolved in a buffer solution is used for calibration in a method for the determination of thyroxine (T4) or triiodothyronine (T3) in ... | 08/30/1994 |
| 5336602 | Expression enhancer and use thereof to increase the yield in the expression of recombinant genes An expression enhancer has a DNA sequence which is capable of forming a t-RNA clover-leaf structure after transcription and hybridizes in that region of the DNA which, after transcription, forms the anticodon loop in the clover-leaf structure with an olig... | 08/09/1994 |
| 5332678 | Process for liberating an analyte from its binding protein A process for the dissolving off of an analyte bound to a binding protein by breakdown of the binding protein using a cleaving agent which cleaves --S--S-- groups into SH groups in the alkaline range, wherein a 1,2-dithiolan-3-carboxylic acid of the formu... | 07/26/1994 |
| 5321129 | Alkyl-substituted aryl-saccharides, surface-active agents which contain such saccharides and their use in diagnostic tests Novel compounds having the general formula S--Ar--X in which S denotes a saccharide residue Ar denotes an aryl residue and X denotes a straight-chained or branched alkyl residue with 2 to 20 carbon atoms, provided that the aryl residue may not be a 4-ethylphenyl, ... | 06/14/1994 |
| 5320945 | Method and reagent for the determination of antithrombin III In order to determine antithrombin III in body fluids by reacting the sample with thrombin and a chromogenic substrate which forms a colour by the action of thrombin and measurement of the colour formed, the reaction is carried out in the presence of dena... | 06/14/1994 |
| 5312743 | Cholesterol esterases with variable substrate specificity For the preparation of cholesterol esterases with variable substrate specificity by cloning of a cholesterol esterase gene, the active center of which has the sequence -Gly-His-Ser-X-Gly-, wherein X signifies an amino acid, into a vector, transformation o... | 05/17/1994 |
| 5312763 | Method for the detection of analytes In order to detect analytes with an immunological method by incubation with receptors and analysis of the complexes formed, a mixture of at least two monoclonal antibodies which are specifically bindable to the analyte and whose cross-reactivities are dif... | 05/17/1994 |
