Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8076098 | Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclo... | 12/13/2011 |
| 8034816 | Hydrates and polymorphs of 4-[[(7)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy--(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament Disclosed are hydrates and polymorphs of 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, processes for preparing them and their use as pharmaceutical compositions. ... | 10/11/2011 |
| 7888363 | Viral polymerase inhibitors An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0 | 02/15/2011 |
| 7838537 | Viral polymerase inhibitors An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R2, R3, M1, M2, M3, M4, Y1 and Z are as ... | 11/23/2010 |
| 7829664 | Modified nucleotide sequence encoding glucagon-like peptide-1 (GLP-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (GLP-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof An isolated chimeric GLP-1 nucleic acid sequence encoding a human pro-insulin leader, a glucagon-like peptide-1 (GLP-1), and a furin cleavable site between the human pro-insulin leader sequence and the GLP-1 is provided. Also provided is an isolated modified chimeri... | 11/09/2010 |
| 7550622 | Cycloalkylamidoacid compounds, processes for making and uses thereof The invention relates to the field of pharmaceutics and more specifically to cycloalkylamidoacid compositions useful in the preparation of cycloalkyaminoacids and oxazolidinediones, and processes for making cycloamidoacids ... | 06/23/2009 |
| 7247767 | Mouse model for psoriasis and psoriatic arthritis A mouse that is deficient for c-Jun and JunB in the epidermis or in which deletion of c-Jun and JunB can be specifically induced in the epidermis, and methods for obtaining such mice. The mice and keratinocytes derived therefrom are useful as an animal model for pso... | 07/24/2007 |
| 7217711 | Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R1 to R3 and n are defined as in claims 1 to 8, the tautomers, enantiomer... | 05/15/2007 |
| 7214703 | Pyrrolidinohydrochinazolines Disclosed are compounds of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar1, Ar2, A, R1, R2, R3, E1 | 05/08/2007 |
| 7183046 | Methods for identifying inhibitors of cytokinesis using CYK-4 proteins Mammalian CYK-4 polypeptides, which are key molecules required for cytokinesis, and DNA molecules encoding them. Screening methods based on biochemical reactions relevant for the function of CYK-4 can be employed to identify compounds interfering with cell division.... | 02/27/2007 |
| 7104470 | Device for producing high pressure in a fluid in miniature A miniaturized device for pressurizing fluid. The device includes a hollow piston that provides a fluid path and a valve member. The valve member is configured for axial movement so that the valve axis remains parallel to the piston axis. The valve member is arrange... | 09/12/2006 |
| 7087412 | Methods for large scale protein production in prokaryotes The invention belongs to the field of protein production in prokaryotic cells. The invention relates to methods for the production of recombinant DNA-derived heterologous protein in prokaryotic cells, wherein the heterologous protein is secreted extracellularly as a... | 08/08/2006 |
| 7052889 | Mammalian SUV39H2 proteins and isolated DNA molecules encoding them Murine and human Suv39h2 polypeptide and DNA molecules encoding them. Suv39h2 is a novel member of the Suv3-9 gene family. Suv39h2 is a novel component of meiotic higher order chromatin. It has histone methyltransferase activity and is required, in combination with ... | 05/30/2006 |
| 6988496 | Cartridge for a liquid For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient at... | 01/24/2006 |
| 6955910 | Method for large scale production of recombinant DNA-derived TPA or K2S molecules The invention belongs to the field of thrombolysis and of tissue plasminogen activator (tPA) derivative production in prokaryotic cells. The invention relates to methods for the production of a recombinant DNA-derived tPA, a variant therof or a (Kringle 2 Serine) K2... | 10/18/2005 |
| 6932789 | Needle-less injector of miniature type Needle-less injectors for liquids are known in many different forms which are adapted to different conditions of use. The needle-less injector according to the invention is in the form of a hand-held unit. It includes a locking stressing mechanism, an energy-storing... | 08/23/2005 |
| 6846413 | Microstructured filter A microstructured filter for a fluid, the filter having an inlet for unfiltered fluid and an outlet for filtered fluid, the filter comprising: a plurality of projections (7) which are arranged in at least two rows (3) in mutually juxtaposed relationshi... | 01/25/2005 |
| 6806066 | Expression vectors with modified ColE1 origin of replication for control of plasmid copy number In an expression vector having a ColE1 replication system, the homology of the RNAI and RNAII of the ColE1 origin of replication to uncharged tRNAs is modified mutations in the coding region of the RNAI gene and corresponding mutations in the RNAII gene. The mutatio... | 10/19/2004 |
| 6716621 | Isolated DNA or gene responsible for Parkinson's disease This invention provides an isolated DNA or gene that is responsible for Parkinson's disease and is useful in diagnosing and treating the disease etc. The isolated DNA or gene according to this invention comprises a full-length base sequence according to the s... | 04/06/2004 |
| 6689583 | Chromatin regulator genes The invention concerns the deregulation of the chromatin-regulator genes which have a SET domain, such deregulation being of importance in certain cancer conditions. These genes can be used in the diagnosis and therapy of such conditions.... | 02/10/2004 |
| 6555329 | Method for identifying compounds altering higher-order chromatin-dependent chromosome stability A method for identifying compounds that alter higher order chromatin dependent chromosome stability is based on determining the compounds' ability to modify a methyltransferase with Suv39h-like methyltransferase activity. The identified compounds are usef... | 04/29/2003 |
| 6503362 | Atomizing nozzle an filter and spray generating device A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members, each with generally planar surfaces, that are joined together. A first set of channels is formed in the generally planar surface of a firs... | 01/07/2003 |
| 6485924 | Method for identifying inhibitors of cytokinesis Method for identifying compounds that inhibit cytokinesis, wherein the compounds are tested for their ability to modulate the formation and/or the stability of septin filaments. The compounds are useful in tumor therapy.... | 11/26/2002 |
| 6453795 | Locking mechanism for a spring-actuated device A spring-actuated output drive device is used for example in medical aerosol therapy for a miniaturised high-pressure producing device for atomising a small dose of a liquid medicament. A locking-stressing-mechanism for such an output d rive device is to ... | 09/24/2002 |
| 6455677 | FAP-specific antibody with improved producibility Recombinant antibody proteins are provided that specifically bind fibroblast activation protein alpha (FAP) and comprise framework modifications resulting in the improved producibility in host cells. The invention also relates to the use of said an... | 09/24/2002 |
| 6372441 | Method for diagnosis and therapy of Hodgkin's lymphomas The invention relates to a method for diagnosing and treating Hodgkin's lymphomas (lymphogranulomatosis) which is based on the expression of the variant exon v10 of the CD44 gene as a molecular marker or target. There is a significant correlation between ... | 04/16/2002 |
| 6335016 | Chicken embryo lethal orphan (CELO) virus A CELO virus obtained by in vitro manipulation of a plasmid-cloned CELO virus DNA is suitable for the production of vectors for gene therapy and as a vaccine against infectious diseases in humans and animals, particularly birds.... | 01/01/2002 |
| 6274322 | Composition for introducing nucleic acid complexes into higher eucaryotic cells A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, ... | 08/14/2001 |
| 6077663 | Composition for introducing nucleic acid complexes into higher eucaryotic cells A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, ... | 06/20/2000 |
| 6022735 | Composition for introducing nucleic acid complexes into higher eucaryotic cells A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, ... | 02/08/2000 |
| 6010865 | Process for detecting a variant CD44 gene product The invention relates to a process for diagnosing and analysing tumours which is based on detecting the expression of certain variant exons of the CD44-gene. Detection may be carried out at the protein or nucleic acid level. In a preferred embodiment the ... | 01/04/2000 |
| 6007676 | Atomizing nozzle and filter and spray generating device A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members, each with generally planar surfaces, that are joined together. A first set of channels is formed in the generally planar surface of a firs... | 12/28/1999 |
| 5922549 | Process for screening substances having a modulating effect on an interleukin-5 receptor mediated cellular signal transmission pathway A process is disclosed for screening substances having a modulating effect on the interleukine-5-receptor-dependent signal tranmission path in mammal cells. Test substances are applied on cells which express the functional interleukine-5-receptor and are ... | 07/13/1999 |
| 5916561 | Monoclonal antibody against CD44v6 The invention concerns an antibody active against an epitope coded by the exon v6 variant of the CD44 gene. The antibody concerned has characteristics superior to those of prior art antibodies and is suitable for use in therapy and diagnosis.... | 06/29/1999 |
| 5911851 | Atomizing nozzle and filter and spray generating device A nozzle assembly for use in atomizing and generating sprays from a fluid. The nozzle assembly includes two members joined together. In one of the two members are formed one or more nozzle outlets, one or more fluid inlets, and a plurality of channels tha... | 06/15/1999 |
| 5792645 | Protein-polycation nucleic acid complexes and methods of use The invention relates to a system for transporting nucleic acids into the cell, which is effected by receptor-mediated endocytosis. Using a transferrin-polycation conjugate, a complex can be formed with the polyanionic nucleic acid. This complex is bound ... | 08/11/1998 |
| 5714143 | Use of manganese superoxide dismutase (MN-SOD) for preparing pharmaceutical compositions for low-dose treatment of diseases The present invention relates to the use of pharmaceutical preparations containing manganese superoxide dismutase in a low dose for treating diseases and conditions caused by free oxygen radicals.... | 02/03/1998 |
| 5712245 | Receptor of the minor human rhinovirus receptor group A substantially pure receptor with binding activity for rhinoviruses of the minor human receptor group is disclosed, which has the following characteristics: (a) a molecular weight of 120 kD on a polyacrylamide gel in the presence of SDS; (b) a sedimentat... | 01/27/1998 |
| 5683878 | Neuroblastoma-associated regulator gene Disclosed is a gene situated in the region of the neuroblastoma consensus deletion 1p36.2-p36.1 which codes for a helix-loop-helix protein with the designation HEIR-1. The loss of this gene is significantly correlated with allelic tumor deletions in neuro... | 11/04/1997 |
| 5662271 | Atomizing devices and methods A metered dose inhaler comprises a piston which is mounted in a cavity within a body, and is urged by a pre-loaded spring into a reduced cross-section pressure chamber. The piston may be loaded by means of an actuating rod having a handle, and may be latc... | 09/02/1997 |
