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| Number | Title | Issue Date |
| 8173699 | Compounds for the treatment of inflammatory diseases Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestina... | 05/08/2012 |
| 8153660 | Piperidyl-propane-thiol CCR3 modulators One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antag... | 04/10/2012 |
| 8148403 | Substituted piperidyl-propane-thiols One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and D are defined as below. Another object of the present invention is to provide agonists or antagonists of CC... | 04/03/2012 |
| 8034809 | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, pro... | 10/11/2011 |
| 8003639 | Substituted prolinamides, the preparation thereof and the use thereof as pharmaceutical compositions The present invention provides new substituted prolinamides of the general formula (I) in which D, L, E, G, J, M, R3, R4, R5, and R13 are defined as in claim 1, their tautomers, their enantiomers, their diastereomer... | 08/23/2011 |
| 8001965 | Capsule for taking an active substance which can be inhaled The invention relates to a novel capsule for receiving an active substance to be administered by inhalation, which is preferably intended for use in a powder inhaler operating on the Bernoulli principle. ... | 08/23/2011 |
| 7994335 | Electronically tuned ligands for asymmetric hydrogenation Disclosed is a new class of chiral bidentate ligands capable of performing asymmetric hydrogenation. Also disclosed are processes of performing asymmetric hydrogenation the chiral bidentate ligands. ... | 08/09/2011 |
| 7977334 | Beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R7 have the meanings given in the claims and specification, the tautomers, the enantiomers, the diaste... | 07/12/2011 |
| 7932273 | 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl) phenylamino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)pyridin-2-ylamino]propionic acid ethylester methansulfonate and its use as a medicament Ethyl 3-[(2-{[4-(hexyloxycarbonylaminoiminomethyl)phenylamino]methyl}-1-methyl-1H-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate methanesulfonate in the crystalline modifications I and II and as the hemihydrate and the use thereof as a pharmaceutical composit... | 04/26/2011 |
| 7923455 | Medicaments for the prevention or treatment of heart failure comprising administration of an anticholinergic The present invention relates to a method for the prevention or the treatment of heart failure comprising administration of a therapeutically effective amount of an anticholinergic 1, medicaments for the prevention or treatment of heart failure comprising one or mor... | 04/12/2011 |
| 7923449 | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders The invention relates to the use of benzimidazolone derivatives of formula (I) for the preparation of a medicament for the treatment of premenstrual and other female sexual disorders. ... | 04/12/2011 |
| 7880016 | Process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides The invention relates to a process for preparing a salt of an optionally substituted 4-benzimidazol-2-ylmethylamino)-benzamidine, characterised in that (a) an optionally correspondingly substituted diaminobenzene is condensed with 2-[4-(1,2,4-oxadiazol-... | 02/01/2011 |
| 7847074 | Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1, R2 and R3 are defined according to claim 1 and to intermediates of ... | 12/07/2010 |
| 7879871 | Crystalline forms of tiotropium bromide The invention relates to a new crystalline forms of tiotropium bromide, processes for preparing them and their use for preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pul... | 02/01/2011 |
| 7878193 | Capsule for taking an active substance which can be inhaled The invention relates to a novel capsule for receiving an active substance to be administered by inhalation, which is preferably intended for use in a powder inhaler operating on the Bernoulli principle. ... | 02/01/2011 |
| 7866474 | Film container A film container (FIG. 4) comprises two rectangular films (5) joined together at their periphery to form a receiving chamber (6) for a filling (7), particularly a pharmaceutical formulation of an active substance, at least one of said fil... | 01/11/2011 |
| 7849851 | Nebulizer A nebulizer having an insertable container and a monitoring device for counting actuations of the nebulizer is proposed. The monitoring device is mounted in a detachable housing part and directly detects movements of container during a nebulizing process, an air sup... | 12/14/2010 |
| 7807693 | Substituted prolinamides, manufacturing, and the use thereof as medicaments The present invention relates to new substituted prolinamides of general formula (I) wherein D, L, E, G, J, M, R3, R4, R5 and R13 are defined as in the specification, the tautomer... | 10/05/2010 |
| 7776830 | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted benzonitrile derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabo... | 08/17/2010 |
| 7772378 | Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to ... | 08/10/2010 |
| 7772191 | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to... | 08/10/2010 |
| 7759054 | Method for detection of nitric oxide (NO) The present invention relates to methods for detection of nitric oxide (NO) by measuring guanosine monophosphate (cGMP). ... | 07/20/2010 |
| 7749961 | Macrocyclic peptides active against the hepatitis C virus Compounds of formula (I): wherein R1, R2, X, R3, D, and the dotted line b are as defined herein; or a pharmaceutically acceptable salt or ester thereof, are useful as inhibitors of the HCV N... | 07/06/2010 |
| 7745621 | Long acting bronchodilators for the treatment of respiratory diseases The invention relates to compounds of general formula 1 wherein n, A, B, D, L, R1, R2, R3 and R4 may have the meanings given in the claims and in the specification, processes for ... | 06/29/2010 |
| 7745585 | Antibodies to interleukin-like epithelial-mesenchymal transition inducer (ILEI) The functional characterization of ILEI to be a novel cytokine involved in epithelial/mesenchymal transition and the identification of biologically active ILEI provides the basis for generating ILEI inhibitors, in particular anti-ILEI antibodies, that are useful in ... | 06/29/2010 |
| 7745414 | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted benzonitrile derivatives as defined herein, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.... | 06/29/2010 |
| 7737156 | Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes The invention relates to the use of selective phosphodiesterase 9A (PDE9A) inhibitors for producing medicaments for improving perception, concentration, cognitive processes, learning and/or memory. ... | 06/15/2010 |
| 7736628 | Powdered inhalants based on modified lactose mixtures as excipient The invention relates to a new process for preparing modified lactose mixtures, these lactose mixtures per se and compositions of medicaments for powder inhalation consisting of one or more micronised active substances and the modified lactose according to the inven... | 06/15/2010 |
| 7732466 | Substituted thiophene carboxamides, process for their preparation and their use as medicaments The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula wherein A, and R1 to R8c are defined as in claim 1, the tautomers, the enantiomers, the dia... | 06/08/2010 |
| 7723309 | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-(()-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments The invention relates to crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments. ... | 05/25/2010 |
| 7721589 | Automated system for impactor testing One aspect of the invention provides an automated system for performing repeated testing using an impactor which comprises a cup manifold defining multiple impaction cups, an impactor head defining transfer passages, and a nozzle manifold which defines multiple nozz... | 05/25/2010 |
| 7713961 | Substituted 1,2-ethylenediamines, methods for preparing them and uses thereof The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1—X4 are defined as in the specific... | 05/11/2010 |
| 7713938 | Crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-(()-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments The invention relates to a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S) -tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments. ... | 05/11/2010 |
| 7709474 | Enantiomerically pure beta agonists, manufacturing and use thereof The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups R1, R2, R3, m and Ym− may have the meanings given in the claims and specificatio... | 05/04/2010 |
| 7691871 | Multivitamin syrup for children or young adults The invention relates to an improved pharmaceutical or dietary composition in form of an aqueous syrup, consisting essentially of (a) vitamins recommended for consumption by children or young adults, (b) a suitable calcium source, (c) at least one dibasic amino acid... | 04/06/2010 |
| 7687469 | Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic d... | 03/30/2010 |
| 7683160 | Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture Glucopyranosyl-substituted benzyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1 | 03/23/2010 |
| 7674788 | Substituted pteridines The invention relates to new pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system and cancers. This invention also r... | 03/09/2010 |
| 7667035 | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides The invention relates to new substituted imidazoles of general formula wherein R1 to R3 and X are defined as in the claims, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and t... | 02/23/2010 |
| 7665461 | Nebulizer A nebulizer for a fluid and a container holding the fluid which is insertable in the nebulizer are proposed. To improve safety in use it is proposed that the nebulizer comprises first coding means and the container is associated with second coding means, so that the... | 02/23/2010 |
