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| Number | Title | Issue Date |
| 7151103 | Method of treating female hypoactive sexual desire disorder with flibanserin The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire. ... | 12/19/2006 |
| 7084118 | Combination treatment with t-PA variant and low molecular weight heparin The invention concerns an improved therapeutic regimen for the treatment of thrombolytic disorders, such as acute myocardial infarction (AMI). In particular, the present invention concerns the treatment of thrombolytic disorders, e.g. AMI, with a combination of a ti... | 08/01/2006 |
| 7070800 | Inhalable powder containing tiotropium The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chro... | 07/04/2006 |
| 7066171 | Process and apparatus for producing inhalable medicaments A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segme... | 06/27/2006 |
| 7012151 | Method for nitrating aniline derivatives The present invention relates to a process for the highly regioselective aromatic nitration of alkyl 4-alkanoylamino-3-alkyl-benzoates in the 5-position in a mixture containing nitric acid and the use of the resulting products for preparing, in particular, pharmaceu... | 03/14/2006 |
| 7005437 | Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions The present invention relates to new substituted aryl and heteroaryl derivatives of general formula wherein A, Ar, n, X, Y1, Y2, Y3, Y4, R | 02/28/2006 |
| 6998406 | Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments Fluorenecarboxylic acid esters of general formula 1 wherein X− and the groups A, R, R1, R2, R3, R3′, R4, and R4′ have the meanings given... | 02/14/2006 |
| 6986346 | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebuliser, as well as an active substance conc... | 01/17/2006 |
| 6983743 | Stainless steel canister for propellant-driven metering aerosols The present invention relates to corrosion resistant stainless steel canisters for propellant-containing aerosol formulations for use in propellant gas-operated inhalers. ... | 01/10/2006 |
| 6982256 | Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration The invention relates to new formulations for improving the local tolerance of intravenously administered 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine or one of the pharmacologically acceptable acid addition salts thereof. ... | 01/03/2006 |
| 6972288 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the steroisome... | 12/06/2005 |
| 6958418 | Process for preparing vanillylamine hydrochloride Process for preparing vanillylamine or one of the salts thereof by reacting vanillin with hydroxylamine or the salts thereof in the presence of an organic salt, which may optionally be produced in situ, wherein the reaction is carried out in an inorganic or organic ... | 10/25/2005 |
| 6958417 | Process for preparing zolpidem A process for preparing a compound of formula (II) wherein R1 denotes bromine, wherein, a compound of formula (IV) ... | 10/25/2005 |
| 6949154 | Method and apparatus for sealing medicinal capsules A method of sealing parts of a plastic capsule by forming a weld seam in an overlapping region of the parts of the capsule, wherein the capsule comprises a capsule cap having an open end and a capsule body having an open end, the method comprising: ... | 09/27/2005 |
| 6949541 | Substituted piperidines, medicaments containing these compounds, and methods for the production thereof The present invention relates to substituted piperidines of general formula wherein A1, A2, R, R1 and R2 are defined as in claim 1, the tautomers, the diastereom... | 09/27/2005 |
| 6924285 | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them The present invention relates to bicyclic heterocyclic groups of general formula wherein Ra, Rb, Rc, Rd and X are defined as in claim 1, the tautomers, the stereois... | 08/02/2005 |
| 6919325 | Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts Pharmaceutical compositions and kits comprising: (a) a tiotropium salt; and (b) a salmeterol salt having a solubility in water of 0.1 mg/mL or less, processes for preparing them, and their use in the trea... | 07/19/2005 |
| 6905239 | Sprinkling method for preparing powder formulations The invention relates to a new process for producing powdered preparations for inhalation wherein a substance having a smaller particle size distribution is metered continuously through a suitable feed device onto a moving bed of a powdered substance having a larger... | 06/14/2005 |
| 6890517 | Inhalable formulation of a solution containing a tiotropium salt A liquid, propellant-free pharmaceutical preparation comprising: (a) a first active substance comprising a tiotropium salt, in a concentration based on tiotropium of between 0.0005% and 5% by weight; (b) a second a... | 05/10/2005 |
| 6884886 | Process for preparing 6-aryl-4H-S-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines An improved process for preparing 6-aryl-4H-s-triazolo[3,4-c]-thieno[2,3-e]-1,4-diazepines of formula I, wherein: R1 is a hydrogen or halogen atom or a C1-C... | 04/26/2005 |
| 6869948 | Meloxicam for oral administration The invention relates in its first aspect to a rapidly decomposing tablet for pain therapy containing meloxicam [4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide] in the form of a salt with an inorganic or organic base provi... | 03/22/2005 |
| 6858641 | Substituted indolinones The present invention relates to indolinones substituted in the 6-position of general formula wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particu... | 02/22/2005 |
| 6855710 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs The present invention relates to new substituted indolinones of general formula wherein X and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable... | 02/15/2005 |
| 6855713 | Benzimidazole derivatives, a process for their manufacture and use as a medicine The invention concerns benzimidazole derivatives of the general formula (I) in which the radicals R1, R2, R3, X1 and A can have the meanings assigned to them in the specifica... | 02/15/2005 |
| 6849734 | Intermediates useful for preparing 4,6-diaminopyrido[5,4-d]pyrimidines 2-Chloro-4,6-diamino-7,8-dihydropyrimido[5,4-d]pyrimidine of the formula II wherein R1 denotes a hydrogen atom or a C1-C6 alkyl group, | 02/01/2005 |
| 6838460 | Substituted phenylamidines medicaments containing said compounds and method for production thereof The present invention relates to phenylamidines of general formula wherein R6 and R7 are defined as in claim 1, the tautomers, the stereoisomers including... | 01/04/2005 |
| 6821967 | Substituted piperazine derivatives, the preparation thereof and their use as medicaments The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, ... | 11/23/2004 |
| 6806272 | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions The present invention relates to new dihydropteridinones of the formula (I) wherein the groups X, R1, R2, R3, R4, R5 and R7 have the meanings given in t... | 10/19/2004 |
| 6800623 | Method of treating schizophrenia A method for treating schizophrenia which comprises administering a compound of general formula (I) ... | 10/05/2004 |
| 6790856 | Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments Flourenecarboxylic acid esters of general formula 1 wherein X− and the groups A, R, R1, R2, R3, R3′, R4, and R4′ have the meanings given ... | 09/14/2004 |
| 6777423 | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions Crystalline monohydrate of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof,... | 08/17/2004 |
| 6773895 | Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases The present invention relates to substances which modulate receptors involved in inflammatory processes and whose modulated functions positively influence inflammatory diseases. ... | 08/10/2004 |
| 6770636 | Phenyl-and phenylalkyl-substituted ethanolamines and ethylenediamines Compounds of formula 1, wherein: R1 is hydrogen, hydroxy, CF3, NO2, CN, halogen, C1-C8-alkyl, or C1-C8-alkoxy; R2, R | 08/03/2004 |
| 6762180 | Substituted indolines which inhibit receptor tyrosine kinases Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1... | 07/13/2004 |
| 6747044 | Neurokinin antagonists The invention relates to new compounds of formula I or the pharmaceutically acceptable salts thereof, wherein R1 denotes 3-hydroxypropyl, 1,3-dihydroxyprop-2-yl or C3-C6-cyc... | 06/08/2004 |
| 6740712 | Polymers based on N-carbamyl-N'-dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries The present invention relates to polymers characterized by novel silicon linkers based on the carbamyl piperazine moiety, methods of preparing these polymers and their use in the solid phase synthesis of compounds or libraries of compounds embracing a phenyl ring in... | 05/25/2004 |
| 6740651 | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases Compounds of the formula having an inhibitory effect on signal transduction mediated by tyrosine kinases, and the use thereof for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tr... | 05/25/2004 |
| 6739333 | Stainless steel canister for propellant-driven metering aerosols The present invention relates to corrosion resistant stainless steel canisters for propellant-containing aerosol forumlations for use in propellant gas-operated inhalers. ... | 05/25/2004 |
| 6737432 | Crystalline form of telmisartan sodium The invention relates to a crystalline sodium salt of 4′-[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazol-1-ylmethyl]biphenyl-2-carboxylic acid (INN: telmisartan), processes for preparing it and the use thereof for preparing a pharmaceutical composit... | 05/18/2004 |
| 6730678 | Benzoylguanidine salt and hydrates thereof 4-[4-(2-pyrrolylcarbonyl)-1-piperazinyl]-3-trifluoromethylbenzoylguanidine hydrochloride and its hydrates, processes for preparing this benzoylguanidine salt and its hydrates, pharmaceutical compositions containing this benzoylguanidine salt and its hydrates, and it... | 05/04/2004 |
