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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 5869698 | 1,2-dioxetane compounds as chemiluminescent labels for organic and biological molecules Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an `activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from... | 02/09/1999 |
| 5795987 | Alkene intermediates for preparing 1,2-dioxetane compounds Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from ... | 08/18/1998 |
| 5770743 | 1,2-Dioxetane compounds as chemiluminescent labels for organic and biological molecules Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an activating agent other than an enzyme which is removed by an activating agent to produce light, wherein A ... | 06/23/1998 |
| 5698728 | Alkene intermediates for preparing 1,2-dioxetanes Novel alkene intermediates useful in the preparation of 1,2-dioxetanes.... | 12/16/1997 |
| 5631353 | Alkene adamantane intermediates and the corresponding 1,2-dioxetanes Alkene adamantane compounds useful as intermediates for producing the corresponding 1,2-dioxetanes which are useful in chemiluminescent assays.... | 05/20/1997 |
| 5616729 | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers Triggerable dioxetanes with a fluorescent substituent bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are of the formula: ##STR1## wherein R1, R2 and R3 ar... | 04/01/1997 |
| 5492769 | Method for the production of scratch resistance articles and the scratch resistance articles so produced A method is provided for improving the scratch or surface wear resistance of substrates by embedding discrete, hard particles within the surface layer of the substrate. Discrete, hard particles are applied to the substrate surface and then embedded within... | 02/20/1996 |
| 5483920 | Method of forming cubic boron nitride films A novel method of forming large area single crystal cubic boron nitride films on a silicon substrate by first treating the surface of the substrate with atomic hydrogen and then depositing a cubic boron nitride film by a reactive biased laser ablation tec... | 01/16/1996 |
| 5438146 | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers Triggerable dioxetanes with a fluorescent molecule containing group bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are useful in immunoassays and in probes using enzymes or other chemicals for... | 08/01/1995 |
| 5386017 | Alkenes for producing chemiluminescent 1, 2-dioxetane compounds Novel alkenes leading to light producing 1,2-dioxetanes of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the 1,2-dioxetane to produce light when triggered by removing X.... | 01/31/1995 |
| 5359110 | Process for the preparation of a R-alpha cyclopentenones and R-alpha and R-omega cyclopentanoids A process for the preparation of R-cyclopentenoids and then R, Rω-cyclopentanoids is described. The process involves the reaction of a compound of the formula ##STR1## where X is halo, particularly Br or I and P is a protecting group w... | 10/25/1994 |
| 5286893 | Alkenoic acid compounds for mechanism-based inactivation of dehydropeptidase activity Alkenoic acid compounds are described. The compounds which are dehydropeptidase inactivators contain a ##STR1## moiety which is substituted with a halomethylene or a cyano moiety as R3. The enzyme deprotonates the alpha --CH2 gr... | 02/15/1994 |
| 5238832 | Aryl aliphatic acids Novel aryl aliphatic acids or derivatives thereof of the general formula R--(Cx --Cy)--(Cm H2m)--G--C(R1)2 --Ar--(Cn H2n)--COOR2 are described which exhibit inhibitin... | 08/24/1993 |
| 5238930 | Alkenoic acid compounds for mechanism-based inactivation of dehydropeptidase activity Alkenoic acid compounds are described. The compounds which are dehydropeptidase inactivators contain a ##STR1## moiety which is substituted with a halomethylene or a cyano moiety as R3. The enzyme deprotonates the alpha--CH2 gro... | 08/24/1993 |
| 5112751 | Method for inactivating dehydropepidase activity irreversibly with alkenoic acid compounds Alkenoic acid compounds are described. The compounds which are dehydropeptidase inactivators contain a ##STR1## moiety which is substituted with a halomethylene or a cyano moiety as R3. The enzyme deprotonates the alpha-CH2 grou... | 05/12/1992 |
| 5102808 | Method and test kit for analysis of histamine receptor sites of mammalian cells A method and test kit for selectively staining histamine or histamine blocker sites on mammalian cells is described. Novel fluorescently labeled histamines or histamine blocker compounds are described. The method allows the visualization of sites on indiv... | 04/07/1992 |
| 5068339 | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers Triggerable dioxetanes with a fluorescent molecule containing group bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are useful in immunoassays and in probes using enzymes or other chemicals for... | 11/26/1991 |
| 5015589 | Method for detecting maternally transferred drug metabolites in newborn infants A method for detecting the presence of drug metabolites in the meconium of newborn infants is described. The method involves separation of the drug metabolites from meconium in solution and then assaying the solution for the presence of the drug metabolit... | 05/14/1991 |
| 5013827 | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers Triggerable dioxetanes with a fluorescent molecule containing group bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are useful in immunoassays and in probes using enzymes or other chemicals for... | 05/07/1991 |
| 4962192 | Chemiluminescent 1,2-dioxetane compounds Novel light producing 1,2-dioxetanes are described of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the 1,2-dioxetane to produce light when triggered by removing X. X is... | 10/09/1990 |
| 4959182 | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a c... | 09/25/1990 |
| 4950680 | Method and compositions for inhibition of tumor cell induced platelet aggregation Compositions and a method for inhibiting tumor cell induced platelet aggregation are described. Platelet aggregation by tumor cells is part of the metastatic cascade which is interrupted according to the present invention. The compounds include a mixture ... | 08/21/1990 |
| 4950590 | Method and kit for assay for measurement of serum thymosin alpha1 A micro-enzyme described immunosorbent assay (microELISA) method is described for detecting small amounts of thymosin alpha1 in a solution such as serum. The method uses a known amount of an antibody to the thymosin alpha1 which is r... | 08/21/1990 |
| 4906646 | Method and composition for the treatment of tumors by administering a platinum coordination compound and a calcium channel blocker compound of the dihydropyridine class A method for the treatment of malignant tumors by co-administering a platinum coordination compound and a dihydropyridine class calcium channel blocker compound is described. The compounds are administered over a period of several days in at least two sep... | 03/06/1990 |
| 4873360 | Process for the preparation of cyclopentanoids and novel intermediates produced thereby Cyclopentanoids (I) of the formula: ##STR1## including stereoisomers are described along with a process for the preparation of I. In particular the preparation of prostanoids of the formula: ##STR2## wherein R1 is a alkyl group c... | 10/10/1989 |
| 4857652 | Chemiluminescent 1,2-dioxetane compounds Novel light producing 1,2-dioxetanes are described of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the 1,2-dioxetane to produce light when triggered by removing X. X is... | 08/15/1989 |
| 4830961 | Method and test kit for analysis of histamine receptor sites of mammalian cells A method and test kit for selectively staining histamine or histamine blocker sites on mammalian cells is described. Novel fluorescently labeled histamines or histamine blocker compounds are described. The method allows the visualization of sites on indiv... | 05/16/1989 |
| 4784945 | Method for determining lipids A method for determining lipids using thin layer chromatography and multiple enzymatic staining is described. The method uses a hydrolase enzyme, an oxidase enzyme and a peroxidase enzyme in the presence of a chromogen precursor to form an oxidized chromo... | 11/15/1988 |
| 4773862 | Method for mapping a joint venture and maps produced thereby A method and map (10) for charting historical events by ventures A and B in a joint venture is described. The method and map enable a visual understanding of the operation of joint venture in the past and possibly more effective development of the joint v... | 09/27/1988 |
| 4666616 | Synergistic antimicrobial or biocidal mixtures Synergistic anti-microbial compositions containing a mixture of a metal complex of a polyfunctional organic liqand and a biocidal composition which contains or releases a lower aldehyde containing 1 to 5 carbon atoms are described. The compositions are pa... | 05/19/1987 |
| 4608183 | Synergistic antimicrobial or biocidal mixtures including isothiazolones Antimicrobial mixtures of isothiazolones and a metal complex with a polyfunctional ligand which are synergistic are described. The mixtures particularly include mixtures of a monocopper disodium citrate as the ligand and a 5-x-2-lower alkyl 4-isothiazolin... | 08/26/1986 |
