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| Number | Title | Issue Date |
| 8163800 | PKC-activating compounds for the treatment of neurodegenerative diseases The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. Th... | 04/24/2012 |
| 7977377 | Treatment of depressive disorders The invention provides for the use of carbonic anhydrase activators; protein kinase C activators and FGF-18 to treat depressive disorders. The invention also relates to improved animal models and methods for screening and identifying compounds the treatment of depre... | 07/12/2011 |
| 7803400 | Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particles comprised of thr... | 09/28/2010 |
| 7682627 | Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particles comprised of thr... | 03/23/2010 |
| 7595167 | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio The present invention is directed to a method of diagnosing Alzheimer's disease in a subject by detecting alterations in the ratio of specific phosphorylated MAP kinase proteins in cells after stimulation with a protein kinase C activator. The Alzheimer's disease-sp... | 09/29/2009 |
| 6825229 | Methods for Alzheimer's Disease treatment and cognitive enhancement The present invention relates to compositions and methods to modulate α-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer's Disease patients, and trea... | 11/30/2004 |
| 6821979 | Synergistic enhancement of cognitive ability The present invention relates to the combination of a methylxanthine and a carbonic anhydrase activator to provide synergistic effects. The invention further relates to the improved/enhanced cognitive ability of individuals, particularly those suffering from various... | 11/23/2004 |
