Assignee: Biovitrum AB

Location: Stockholm, SE
No. of patents: 43

Number	Title	Issue Date
7820675	Benzofuran compounds The present invention relates to compounds of formula (I): wherein P, R3, W1, and W2 are as described herein, to pharmaceutical compositions comprising the compounds, to processes ...	10/26/2010
7709526	Use of cyclolignans and new cyclolignans Compounds which inhibit the insulin-like growth factor-1 receptor (IGF-1 R) and methods for using them for treating IGF-1 R dependent diseases, such as cancer. ...	05/04/2010
7671051	Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament whic...	03/02/2010
7666888	Substituted azole aromatic heterocycles as inhibitors of 11β-HSD-1 Compounds of formula I and IV are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorder: wherein the variables A-B, R1, R2, m, a...	02/23/2010
7618961	Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which ac...	11/17/2009
7572787	Substituted naphthalene sulfonamides The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obe...	08/11/2009
7534794	Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2—, �...	05/19/2009
7285392	Methods for identifying active compounds The present invention relates to methods for identifying agents that modulate the effect of cytokine class I receptor binding compounds, by inhibiting the interaction between the cytokine class I receptor and nuclear factors. The agents are useful for decreasing IGF...	10/23/2007
7253196	Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R	08/07/2007
7226925	Compounds, their use and preparation The invention relates to compounds of the general Formula (I): The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related ...	06/05/2007
7173030	Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and fo...	02/06/2007
7144883	Bicyclic sulfonamide compounds The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obe...	12/05/2006
7132436	Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which act...	11/07/2006
7125900	Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which act...	10/24/2006
7094792	Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and fo...	08/22/2006
7074788	Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and fo...	07/11/2006
7045294	Promoter sequences The present invention relates an isolated human Site-1 Protease promoter region. The invention also relates to screening methods for agents decreasing the expression of Site-1 protease and thereby being potentially useful for the treatment of medical conditions rela...	05/16/2006
7030135	Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to using a compound having the formula (I) wherein T is I) thienyl, which optionally is substituted with halogen, or II) phenyl optionally substituted with halogen and/or C1-6-alkyl; E is a bond, —CH2— or —CO...	04/18/2006
6969710	Compounds The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II...	11/29/2005
6891035	Process for bulk autoclaving Process for bulk autoclaving of polysaccharides, wherein the process includes: a) dissolving the polysaccharides in an aqueous solution and mixing until a homogeneous solution is obtained; b) filling the resulting solution in at least one container; c) placing the f...	05/10/2005
6818639	Pharmaceutical combination formulation and method of treatment with the combination The invention relates to method of preventing or treating a disease related to the 5-HT2C receptor and the 5-HT6 receptor, comprising administering to a human or animal subject in need thereof a 5-HT2C receptor agonist and a 5-HT	11/16/2004
6773919	Expression vector for production of recombinant proteins A method of enhancing the transcription of a gene in a DNA construct incorporated into the genome of a eucaryotic host cell, wherein the DNA construct comprises a structural gene for a desired protein or polypeptide in a gene promoter upstream of the structural gene...	08/10/2004
6773414	Device and method for dispensing at least two mutually reactive components A device for dispensing at least two mutually reactive components, such as fibrinogen and thrombin, comprising a supplier (12A, 12B) having a primary channel for supplying a respective one of said at least two reactive components to a dispenser (14	08/10/2004
6759401	Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2—, —NH—, (ii) a C1-4-alky...	07/06/2004
6756377	Compounds and their use The invention relates to compounds of the general formula (I) wherein R1, R2 and R3 are as described in the specification, which compounds are ligands to the serotonin 5-HT2c receptor. ...	06/29/2004
6740734	Bacterial receptor structures Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which have been se...	05/25/2004
6723553	Promoter sequences The present invention relates an isolated human Site-1 Protease promoter region. The invention also relates to screening methods for agents decreasing the expression of Site-1 protease and thereby being potentially useful for the treatment of medical conditions rela...	04/20/2004
6709860	Animal model According to the invention, a major role for the winged helix protein FKHL14/FOXC2 in regulating energy balance and adiposity is demonstrated. The invention relates to transgenic non-human mammalian animals being capable of expressing the human FKHL14/FOXC2 gene in ...	03/23/2004
6602977	Receptor structures The present invention relates to modified polypeptide derivatives of the B domain or Z domain of staphylococcal protein A (SPA). The derivatives contain amino acid substitutions that result in the ability of the B domain or Z domain to interact with at le...	08/05/2003
6599724	Stable factor VIII compositions The present invention relates to a pharmaceutical composition comprising Factor VIII and the divalent metal ions Zn2+ and Cu2+, optionally in the presence of Ca2+ ions and/or Mn2+ ions, wherein said Factor VIII ...	07/29/2003
6586188	Method for identification of compounds that bind to ଲ-tubulin and stimulate insulin secretion According to the invention ଲ-tubulin, as well as a 65 kDa polypeptide present in pancreatic ଲ-cells, have been identified as molecular targets for sulfonylurea compounds. These findings enable for the identification of new insulin secretagogue...	07/01/2003
6573291	Method and use The invention relates to a method of antagonizing GLP-1 activity in a mammalian patient, comprising administering to said patient an effective amount of a compound of the general formula I: ##STR1## wherein R1 and R2 independently of...	06/03/2003
6534628	Bacterial receptor structures Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which h...	03/18/2003
6498182	Compounds The present invention is directed to compounds of formula I, formula Ia, and formula Ib. ##STR1## wherein each of R1, R2, R3, R4, Ra, and Rb has been defined herein. The invention is also d...	12/24/2002
6486306	Filtration Filtration methods comprise virus-filtering a solution containing a least one macromolecule. In one embodiment, the total salt content of the solution is within the range of from about 0.2 M to 2 M. In another embodiment, the total salt content of the sol...	11/26/2002
6472515	Response element The present invention is directed to a novel Afx response element comprising the nucleotide sequence AACATGTT, said nucleotide sequence having a DNA binding site for the human fork head transkription factor Afx. The invention also relates to the use of th...	10/29/2002
6465467	Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases Compounds of the general formula (I): wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2 receptor-related, diseases in human beings or animals, particularly ...	10/15/2002
6451978	Purification of antithrombin-III-଱ and ଲ PROTEIN PURIFICATION I The invention relates to processes for preparation of substantially pure antithrombin-III (AT-III), the antithrombin isoforms AT-III଱ and AT-IIIଲ and/or histidine-rich glycoprotein (HRGP). The processes comprise separating t...	09/17/2002
6451548	Methods for screening for specific inhibitors of trap and identifying compounds for treatment of diseases or conditions resulting in increased bone resorption using activated TRAP The invention relates to the use of activated TRAP (tartrate-resistant and purple acid phosphatases) for screening for specific inhibitor of TRAP activity useful in the treatment of diseases or degenerative conditions resulting in increased bone resorptio...	09/17/2002
6440427	Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer A tissue treatment composition, especially an adhesive composition comprises (i) fibrin or fibrinogen and (ii) a biodegradable and biocompatible polymer capable of forming a viscous aqueous solution. In addition to glueing, the tissue adhesive composition...	08/27/2002

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Assignee: Biovitrum AB