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| Number | Title | Issue Date |
| 8158410 | Recovery of rare cells using a microchannel apparatus with patterned posts A microflow apparatus for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The posts are spaced across the width of a collection region in the flow pat... | 04/17/2012 |
| 8076127 | Recovery of rare cells using a microchannel apparatus with patterned posts A microflow apparatus for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The posts are spaced across the width of a collection region in the flow pat... | 12/13/2011 |
| 7695956 | Device for cell separation and analysis and method of using A microflow device for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts which are arranged across the width of a collection region in an irregular or se... | 04/13/2010 |
| 7638464 | Three dimensional format biochips A biochip is formed with a plurality of optically clear hydrogel cells attached to the top surface of a solid substrate in the form of an array. Each of the cells is formed of a hydrogel of polyethylene glycol, polypropylene glycol or a copolymer thereof having reac... | 12/29/2009 |
| 7595157 | Microarrays utilizing hydrogels A method of making a microarray by coating a flat substrate with a polymerizable hydrogel layer which contains anchoring moieties dispersed uniformly therethroughout. Following curing, a continuous layer of uniform thickness is securely attached to the upper surface... | 09/29/2009 |
| 7468249 | Detection of chromosomal disorders Methods for detecting in a single assay any one of multiple chromosomal disorders that result from aneuploidy or certain mutations, particularly microdeletions, and kits for use therein. A polymerase chain reaction (PCR) is carried out to amplify eukaryotic genomic ... | 12/23/2008 |
| 7439062 | Beads for capturing target cells from bodily fluid Spheroidal beads present an exterior surface of a hydrophilic hydrogel, which is an isocyanate-functional polymer that is polymerized by urethane bonds and cross-linked by urethane and urea bonds. Sequestering agents present at the surface are covalently bound to is... | 10/21/2008 |
| 7258990 | Alleviation of non-specific binding in microarray assays A post-incubation treatment is employed to effectively remove targets, such as proteins/protein complexes, or other label-bearing moieties that may non-specifically bind to a microarray substrate during a binding assay. Following incubation, a one-step wash is carri... | 08/21/2007 |
| 7238521 | Microarray hybridization device having bubble-fracturing elements A novel hybridization device that improves the efficiency and consistency of microarray hybridization reactions by achieving a greater degree of internal mixing of target solution. The device provides a gasket-and-cover-type chamber wherein solution mixing is achiev... | 07/03/2007 |
| 7217520 | Microwell biochip Microwell biochips (11) are formed from a thin flat plate (13) of polymeric material having a plurality of regularly spaced holes (15) that extend completely therethrough and create microwells. The lower end of each hole is closed by a microporo... | 05/15/2007 |
| 7198901 | Reflective substrate and algorithms for 3D biochip A reflective substrate is used to amplify the photon signal captured from overlying analyte domains containing photon emitters. The reflective substrate provides substantial desired signal amplification of the photon emissions from each domain via interference effec... | 04/03/2007 |
