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| Number | Title | Issue Date |
| 4878008 | Contour-clamped homogeneous electric field generator A contour-clamped homogeneous electric field generator having a plurality of electrodes, each electrode being connected to a node which is maintained at a prescribed electrical potential. The electrical potential at the node is maintained by sourcing curr... | 10/31/1989 |
| 4750100 | Transfection high voltage controller A transfection high-voltage controller for directing high-voltage currents to a suspension of cells and DNA comprising a control section, a power store, and a high-joule switch. Under control of the control section, the high-joule switch directs a high-vo... | 06/07/1988 |
| 4745183 | Use of hydroxylapatite for the analysis and preparation of purified monoclonal antibodies A novel method is disclosed for the purification of monoclonal antibodies from antibodies of the same isotype but different light chain composition which are frequently present in the fluids in which such antibodies are generated. According to the method,... | 05/17/1988 |
| 4725343 | High performance electrophoretic mobilization of isoelectrically focused protein zones Protein zones which have been isoelectrically focused in a separation medium are mobilized for analytical or preparative purposes by changing the anolyte, catholyte or both to provide these two solutions with pH's varying in the same direction from the is... | 02/16/1988 |
| 4705056 | Destaining apparatus for electrophoresis gels A multiple gel destaining apparatus is disclosd, in which the gels are laid out horizontally in a series of trays arranged in a stack. Each tray accommodates either one slab gel or one layer of tube gels. The trays are of interchangeable construction, and... | 11/10/1987 |
| 4704366 | Process for binding IgG to protein A Unusually strong binding of IgG to protein A is achieved by contacting these components in the presence of a medium containing a high concentration of salt. Although such binding is of general utility, a particularly useful application is the purification... | 11/03/1987 |
| 4702266 | Destaining apparatus for electrophoresis gels A multiple gel destainiing apparatus is disclosed, in which the gels are laid out horizontally in a series of trays arranged in a stack. Ech tray accomodates either one slab gel or one layer of tube gels. The trays are of interchangeable construction, and... | 10/27/1987 |
| 4699706 | Method and apparatus for extraction of species from electrophoresis media Electrophoretic extraction of molecular species from a separation medium such as a gel segment is achieved by placing the separation medium in a tube closed at one end by a retaining material such as glass frit, and sealing the closed end of the tube agai... | 10/13/1987 |
| 4663015 | Electrophoresis apparatus for nucleic acid sequencing An integrated plate structure provides a novel component for use in an electrophoretic sequencing cell. The integrated plate structure consists of a glass plate and a plastic plate bonded together along a raised edge of the latter, the edge extending alon... | 05/05/1987 |
| 4616329 | Self-calibrating adaptive ranging apparatus and method Apparatus and method for calibrating an adaptive ranging A/D converter wherein a noise having known statistical properties is deliberately superposed on the reference DC signals used to calibrate the gain-ranging amplifier. The amplitude of the noise is c... | 10/07/1986 |
| 4612710 | Method and apparatus for drying gel slabs An apparatus for drying gel slabs supplies heat to a horizontal gel slab from a heating plate above the slab, while drawing a vacuum beneath. The heating plate is weighted and has a flat lower surface at least coextensive with the gel slab. The slab itsel... | 09/23/1986 |
| 4608146 | Horizontal electrophoresis cell for rapid assembly An electrophoresis apparatus for use with horizontally disposed separation media is disclosed, comprised of a housing with lid, and removable components capable of applying an electric potential across a horizontally disposed medium, the components adapte... | 08/26/1986 |
| 4574040 | Apparatus for vertical gel electrophoresis An electrophoresis cell assembly is disclosed which accommodates one or more vertically oriented gels of either slab or tube geometry held in a lateral enclosure attachable to a U-shaped frame to form a liquid-tight upper buffer chamber surrounding the up... | 03/04/1986 |
| 4563275 | Chromatography column and end plug assembly A novel column cartridge for a chromatography apparatus, particularly HPLC, is comprised of a hollow metal tube, open at both ends and having internal shoulders facing each open end, and a pair of end plugs each having a frusto-conical shape at its outer ... | 01/07/1986 |
| 4518476 | End clamp for gel slab plate assembly A novel device for clamping together a sandwich-type gel slab plate assembly includes an elongate housing having a recess on one side and two movable bars placed parallel to each other inside the recess. Due to a series of angled parallel surface segments... | 05/21/1985 |
| 4511662 | Simultaneous assay for T and B lymphocyte populations and subpopulations An assay for simultaneously determining the ratio of B cells and T cells to the total cell population and subpopulations thereof present in a lymphocyte population utilizes excess amounts of B cell binding protein and T cell binding protein bound to solid... | 04/16/1985 |
| 4454232 | Estriol assay An improved immunoassay technique for determining the presence of estriol in human sera comprises adding preselected amounts of a non-ionic detergent and a surface active agent to the assay medium to lessen inaccuracies resulting from variable serum prote... | 06/12/1984 |
| 4448888 | Compositions and method for correcting temperature dependence of hemoglobin assays Artificially constituted storage-stable hemoglobin compositions for use in the temperature correction of a cation exchange column chromatographic assay for hemoglobin A1 or A1c in a sample of human blood. The relative amounts of hemo... | 05/15/1984 |
| 4420690 | Spectrometric microsampling gas cells A sample cell for absorption spectrometry of small volume samples in a continuously flowing carrier gas stream is in the form of an elongate small-bore hollow tube with optically transparent end windows -sealed to the tube and held so as to axially captiv... | 12/13/1983 |
| 4413908 | Scanning interferometer control systems A scanning interferometer is provided with a substantially monochromatic reference beam having a wavelength outside the spectral region of principal interest. Modulation of the reference beam provides a measure of the scan velocity that is compared with a... | 11/08/1983 |
| 4409335 | Method for eliminating glucose dependent Schiff base effect from hemoglobin A1 assay An ion exchange method for the separation of hemoglobin A1 from its Schiff base precursors and from nonglycosylated hemoglobin in a sample of human blood. The known method of lysing the sample, using it to impregnate a weak cation exchange resi... | 10/11/1983 |
| 4389491 | Method and kit for chromatographic separation of hemoglobin A1c An ion exchange method and kit for the separation of hemoglobin A1c from other hemoglobin components in a sample of human blood. The sample is lysed, then used to impregnate a weak cation exchanger. Two buffer solutions are then passed through ... | 06/21/1983 |
| 4295199 | Automatic fluorometer and data processor for performing fluorescent immunoassays Apparatus is disclosed for quantitating relatively small amounts of a clinically significant compound which had been fluorescently tagged. The apparatus has a transparent cell for holding a prepared liquid sample (which includes fluorescent particles). A ... | 10/13/1981 |
| 4282882 | Apparatus for modifying intraocular pressure A cup for use with a vacuum apparatus to modify intraocular pressure by applying a distorting force to the sclera is in the form of a rigid thick-walled hollow cone with beveled base edges dimensioned to fit the curvature of the scleral surface. The insid... | 08/11/1981 |
| 4271123 | Automated system for performing fluorescent immunoassays A sample analyzer for quantitating relatively small amounts of clinically significant compounds in a liquid sample together with a sample mixing device (sampler) is disclosed. The analyzer has a transparent cell for holding the liquid sample. A light sour... | 06/02/1981 |
| 4259289 | Apparatus for retrieving liquid samples from test tubes Apparatus is disclosed for mixing and then withdrawing a sample of a liquid suspension from a multiplicity of upright vials for subsequent processing of the sample in individual batches. A holder supports the vials in a row and advances them in incrementa... | 03/31/1981 |
| 4254096 | Reagent combination for solid phase immunofluorescent assay An assay method suitable for antigens (or haptens) including proteins and polypeptides utilizing antibodies for the unknown protein or polypeptide in which the antibodies are covalently bound to water insoluble hydrophilic polymeric particles. Appropriate... | 03/03/1981 |
| 4246222 | Gel slab casting A method and apparatus for casting gel slabs useful in electrophoretic procedures is provided. Glass plates are horizontally positioned in parallel a capillary action-inducing distance apart to form an unsealed space. Gel-forming liquid, e.g. polyacrylami... | 01/20/1981 |
| 4237218 | Micro-carrier cell culture Insoluble cationic acrylamide copolymers for use as cell growth carriers and a novel copolymer of dimethylaminopropylmethacrylamide, acrylamide and methylene-bis-acrylamide useful as both a carrier for cell growth and as a medium for ion exchange chromato... | 12/02/1980 |
| 4201763 | Solid phase immunofluorescent assay method An assay method suitable for antigens (or haptens) including proteins and polypeptides utilizing antibodies for the unknown protein or polypeptide in which the antibodies are covalently bound to water insoluble hydrophylic polymeric particles. Appropriate... | 05/06/1980 |
| 4190517 | Electrophoresis apparatus Electrophoresis apparatus having a housing, a substantially horizontal cooling bed within the housing for supporting and cooling a medium during electrophoresis, a transparent cover overlying the bed, and first and second electrode troughs along opposed s... | 02/26/1980 |
| 4188188 | High density lipoprotein cholesterol assay A reagent composition useful in assays for high density lipoprotein (HDL) cholesterol comprises heparin and a salt of a divalent metal cation such as MnCl2 dispersed in an inert filler comprising a polysaccharide, a terminal interlocking linear... | 02/12/1980 |
| 4135880 | Folate assay with ion exchange resin bound-free separation Improved competitive binding serum folate assay in which serum folate bound by folate-selective protein is separated from free serum folate by removal with an anion exchanger, preferably intermediate base anion exchange resin. Preferable are resins charac... | 01/23/1979 |
| 4108974 | Radioimmunoassay for thyroid hormone The method of this invention is characterized by the use of hydrolyzed cross-linked polyacrylamide particles to which have been bonded, by means of covalent bonds, antibiodies against the thyroid hormone to be determined. The particles selected are of a s... | 08/22/1978 |
| 4088746 | Radioimmunoassay for thyroid-stimulating hormone (TSH) This invention provides a method for the radioimmunoassay of thyroid-stimulating hormone which utilizes a rapid and convenient version of a double antibody procedure. Highly purified second antibody is bound, by means of covalent bonds, to hydrolyzed poly... | 05/09/1978 |
| 4086059 | Method for the analysis of thyroid hormones Method for competitive binding in diagnostic clinical testing for thyroid function in which blood serum is sufficiently acidified to inactivate binding of thyroid hormone to serum proteins. The serum test solution is then mixed directly with a buffered co... | 04/25/1978 |
| 4028465 | Assay method for serum folate Serum folate assay procedure by competitive binding in which serum folate is stabilized while being freed from serum folate proteins in the presence of a dithiopolyol, preferably a 1,4-dithiotetritol such as dithiothreitol. Subsequently in the procedure, ... | 06/07/1977 |
| 4021324 | Method for electrophoretic destaining Electrophoretic gels are destained between two layers of ion exchange resin. Electrical current is passed from one layer of resin to the other through the gel in an electrically low-conductive surrounding medium such as de-ionized water. Virtually all of ... | 05/03/1977 |
| 4015939 | Competitive binding thyroid assay with improved bound-free separation step Improved competitive binding thyroid hormone assay in which thyroid hormone bound by thyroid binding protein is separated from free thyroid hormone by removal with an intermediate base anion exchange resin. Typical are resins characterized by having an al... | 04/05/1977 |
| 3948743 | Method for gel electrophoresis Gels for electrophoresis such as polyacrylamide gels are formed in a neutral pH medium containing a salt solution of preselected concentration. This salt is incorporated in the gel and in subsequent use in electrophoresis is displaced upon application of ... | 04/06/1976 |
