Assignee: Bio-Rad Laboratories, Inc.

Location: Hercules, CA
No. of patents: 296

«First «Previous1 2 3 4 5 6 7 8 Next»Last»

Number	Title	Issue Date
8137987	Simultaneous assay for determining drugs Bodily fluid is analyzed for the presence of drugs of a selected panel of drugs in a simultaneous assay in which sample of the fluid is incubated with additional amounts of all drugs of the panel, antibodies specific to each of the drugs of the panel, and microparti...	03/20/2012
8136539	Wash ring assembly and method of use Devices, including a wash ring assembly, and methods are provided for the removal of excess fluid or solids from the exterior or interior of a probe used to transfer fluids, for instance, in an automated assay device. Typically, a probe is used to aspirate and dispe...	03/20/2012
8128816	Piston movement control for preparative chromatography column In an axial-flow preparative chromatography column that contains a piston, commonly termed an adaptor, that is lowered over the top of the resin, the ability to lower the piston in a controlled manner to minimize the chances of damage to the resin is achieved by use...	03/06/2012
8128799	Welded electrophoresis cassette without leakage-prone weld line A slab gel cassette is formed from generally flat plates welded together along their borders with a gel space between the plates that is open at the top and bottom edges of the plates to expose the opposing ends of a gel in the gel space to buffer solutions in which...	03/06/2012
8114580	Simulation of normal fresh blood platelets for reference control The present invention provides for novel analogs of fresh human platelets for use in hematological instrument. Methods for preparing such analogs are also described. ...	02/14/2012
8099257	Biometric quality control process Systems and methods configured to guide and manage laboratory analytical process control operations. A Biometric quality control (QC) process application is configured to monitor bias and imprecision for each test, characterize patient population data distributions ...	01/17/2012
8093364	Enhanced purification of antibodies and antibody fragments by apatite chromatography Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparati...	01/10/2012
8075755	Polymeric sorbent sheets as ion reservoirs for electroblotting Electroblotting for the transfer of electrophoretically separated species from a gel to a transfer membrane is performed in a semi-dry format with sheets of absorbent polyester or polyester/cellulose blend wetted with buffer solution in place of the traditional buff...	12/13/2011
8059001	System and method for automatic quality control of clinical diagnostic processes A system and method to automatically implement quality control of a clinical diagnostic process are disclosed. Upon generation of an internal error flag, a confirmation rule automatically checks a questionable patient statistic alert by testing a quality control spe...	11/15/2011
8055450	Method and apparatus for temperature control A method is disclosed. The method includes determining an amount of energy needed to change a first sample temperature of a first sample to a target temperature when a temperature changing element that changes the sample temperature is at the target temperature. Dat...	11/08/2011
8053565	Multi-media affinity column to prevent leaching of ligands In an affinity-type purification, ligands dissociated from a packed bed that would otherwise leach into the solution containing the species being purified are captured by a second ligand that resides in a porous barrier downstream from the packed bed, the second lig...	11/08/2011
8043838	Electroporation cuvette with spatially variable electric field An electroporation cuvette is constructed with electroporation electrodes arranged in non-parallel relation to form a gap whose width varies with the location within the cuvette, plus a pair of positioning electrodes that are arranged to cause electrophoretic migrat...	10/25/2011
8021894	Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d...	09/20/2011
8017740	Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers This invention relates to the use of mixed mode chromatography for purification of at least one intact non-aggregated antibody from a mixture containing intact non-aggregated antibodies and undesirable materials, including fragmented or aggregated antibodies, host c...	09/13/2011
8017381	Composite electroporation plate with interchangeable well inserts Electroporation on a plurality of samples of membranous structures is performed in an electroporation well plate that includes a frame that can hold a plurality of well strips to form a two-dimensional array of wells, and a set of well strips, the set containing str...	09/13/2011
8017342	Solid phase immobilization of phospholipids and cofactor proteins via covalent attachment The present invention provides methods and reagents for detecting anti-phospholipid-cofactor protein-antibodies. ...	09/13/2011
8012768	System and method for multi-analyte detection The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carou...	09/06/2011
8008063	Individual-cell electroporation using area-focused electric fields Electroporation is performed on a population of cells, liposomes, vesicles, or other membrane-encased structures with uniform results regardless of size variations within the population, by drawing the membrane-encased structures into micron-sized openings that cont...	08/30/2011
7999221	Mass spectrometric detection of material transferred to a surface The present invention provides methods for using detection methods, including mass spectrometry methods such as SELDI-TOF-MS, to detect and analyze molecules directly transferred from a sample to a surface to form a molecular print of the sample. Methods and composi...	08/16/2011
7999085	Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers This invention relates to the use of mixed mode chromatography for purification of a protein from a mixture containing other materials, including fragmented or aggregated antibodies, host cell proteins, DNA, endotoxin, and/or virus. This invention further relates to...	08/16/2011
7998680	Determining genotype of a polymorphic site in the hereditary hemochromatosis gene The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the ...	08/16/2011
7958736	Thermoelectric device and heat sink assembly with reduced edge heat loss An assembly that includes one or more thermoelectric devices and a heat sink and that corrects the problem of an uneven heating effect across the area occupied by the devices due to a lateral heat loss at the edges of the devices or other anomalies among the devices...	06/14/2011
7955573	Low-mass sample block with rapid response to temperature change A sample block for use in the polymerase chain reaction, DNA sequencing, and other procedures that involve the performance of simultaneous reactions in multiple samples with temperature control by heating or cooling elements contacting the bottom surface of the bloc...	06/07/2011
7955555	System and method for multi-analyte detection The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carou...	06/07/2011
7952056	Extended dynamic range light detection systems and methods Systems and methods for detecting and measuring light emitted from a sample and having a large dynamic range, e.g., a range of luminous intensity covering six or more orders of magnitude, that may be difficult to fully detect using a single detector with a limited d...	05/31/2011
7947465	Simultaneous assay for determining drugs Bodily fluid is analyzed for the presence of drugs of a selected panel of drugs in a simultaneous assay in which sample of the fluid is incubated with additional amounts of all drugs of the panel, antibodies specific to each of the drugs of the panel, and microparti...	05/24/2011
7943367	High-throughput electroporation chamber with functional lid for risk reduction A chamber that includes electrical contacts and a protective lid with a manually operated release is designed to receive a multi-well electroporation plate and to allow high-throughput electroporation on the well contents with minimal risk of electrical shock to the...	05/17/2011
7923238	Multi-channel electroporation system Systems, methods and apparatus provide flexible and efficient high throughput electroporation systems. An electrical pulse may be transmitted to any number of channels of a multi-channel sample plate. Drivers can provide the selection of which channels to transmit t...	04/12/2011
7919296	Nucleic acid modifying enzymes This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytical...	04/05/2011
7863048	Coumarin-based cyanine dyes for non-specific protein binding Protein dyes whose molecular structure is that of a coumarin moiety coupled to a quaternary ammonium heterocycle through a vinyl or polyvinyl linkage demonstrate the ability to associate with proteins in a non-covalent, non-specific manner at low pH, where the assoc...	01/04/2011
7860685	Method for clustering signals in spectra Methods for processing spectra are disclosed. The method includes obtaining a plurality of spectra, each spectrum in the plurality of spectra comprising a signal including a signal strength as a function of time-of-flight, mass-to-charge ratio, or a value derived fr...	12/28/2010
7842498	Hydrophobic surface chip The invention provides a water-swellable hydrophobic hydrogel and analytical devices incorporating the hydrogel of the invention. Also provided are methods of using the hydrogel to prepare the analytical devices and methods of using the analytical devices to detect,...	11/30/2010
7833625	Materials, methods and systems for separating and identifying proteins from mixtures Materials, apparatuses, methods, and systems for isolating and identifying mixture components on the basis of isoelectric point (“pI”). In one aspect, the materials are particles adapted to have a predetermined isoelectric point. The particles include a porous b...	11/16/2010
7815783	Multi-compartment filter and method of filtering using same Each embodiment includes a central sample reservoir and a plurality of satellite reservoirs. In a first embodiment, a first electrode in electrical contact with the central reservoir is charged and second electrodes in electrical contact with the satellite reservoir...	10/19/2010
7799555	Apparatus for high-throughput electroporation An electroporator for high-throughput electroporation is constructed with a well plate in which each well has internal electrodes that extend beyond the opening of the well to form contact areas, either as horizontal platforms extending laterally from the well rims ...	09/21/2010
7771933	Localized temperature control for spatial arrays of reaction media Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat from a single region within ...	08/10/2010
7754861	Method for purifying proteins The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moietie...	07/13/2010
7754060	Electrophoresis cassette with collapsible buffer chamber A slab gel electrophoresis cassette with an integrated upper buffer chamber is constructed such that the integrated chamber is collapsible to allow the cassette to assume a reduced thickness for purposes of stacking during storage and shipping. ...	07/13/2010
7750605	Controlling an electrical signal sent to a sample load using a pulse modulated resistance Systems, methods, apparatus, and circuits for controlling an electrical signal transmitted to a sample load are provided. The electrical signal produced by a capacitor is controlled via a control signal sent to a variable resistance device that is connected in paral...	07/06/2010
7727477	Apparatus for priming microfluidics devices with feedback control A priming unit for a microfluidics device contains a pressurization unit and pressure and temperature detectors as part of a feedback loop that controls the pressure applied by the pressurization unit and the time during which the pressure is applied. This control f...	06/01/2010

«First «Previous1 2 3 4 5 6 7 8 Next»Last»

PatentStorm

Quotables

PatentStorm News

Assignee: Bio-Rad Laboratories, Inc.