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| Number | Title | Issue Date |
| 8168864 | Transgenic pollen expressing exogenous plant vacuolar pyrophosphatase and methods for increasing seed production in plants Methods are provided for imparting desirable phenotypic traits to transgenic plants, among them being increased tolerance to external stresses such as drought, freezing temperatures, high salt conditions, and the like. In addition, the present invention is directed ... | 05/01/2012 |
| 8129131 | Pin1 as a marker for abnormal cell growth Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating... | 03/06/2012 |
| 8119140 | Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human. ... | 02/21/2012 |
| 8097005 | Suture system A suture system includes a plurality of double-stranded needles connected in sequence with a single-stranded needle at each end. The double-stranded suture needles incorporates two suture strands into a single needle. The suture system of the present invention facil... | 01/17/2012 |
| 8093288 | Genipin derivatives and uses thereof Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed. | 01/10/2012 |
| 8084020 | Use of anti-CD1 antibodies for the modulation of immune responses The invention provides methods for the administration of an anti-CD 1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, aller... | 12/27/2011 |
| 8058515 | Plant cells and plants overexpressing vacuolar proton pyrophosphatases The present invention relates to a transgenic plant, comprising one or more plant cells transformed with exogenous nucleic acid which increases expression of vacuolar pyrophosphatase in the plant. Also encompassed by the present invention are transgenic progeny and ... | 11/15/2011 |
| 8038595 | Devices and methods for tissue transplant and regeneration Devices and methods for transplanting tissue for the purpose of regeneration, for treating a patient having injured myocardial tissue, and/or for improving cardiac function through cell regrowth. More specifically, the devices and methods obviate the need for cellul... | 10/18/2011 |
| 7981915 | Methods for modulating PPAR biological activity for the treatment of diseases caused by mutations in the CFTR gene This invention features methods for treating diseases associated with mutations in the CFTR gene by administering PPAR agonists, specifically PPARγ, PPARα, and PPARδ agonists, PPAR inducers, and/or antioxidants. Also disclosed are screening methods for identifyin... | 07/19/2011 |
| 7955805 | Nucleic acids and polypeptides useful for diagnosing complications of pregnancy Disclosed herein are methods for diagnosing or treating pregnancy related hypertensive disorders that include the use of a polypeptide or a nucleic acid encoding a polypeptide selected from the following: follistatin related protein, interleukin 8, inhibin A, VEGF-C... | 06/07/2011 |
| 7947449 | Methods of diagnosing pre-eclampsia or eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 05/24/2011 |
| 7925336 | Differentiating ischemic from non-ischemic T-wave inversion A method of discriminating between ischemic and cardiac memory effects in a heart, comprising receiving electrocardiographic (ECG) data, calculating, from the ECG data, a direction of a T-wave vector, diagnosing ischemia if the T-wave vector is between about 75 degr... | 04/12/2011 |
| 7882167 | Complexity-based dynamical analysis of a network In a subject undergoing therapeutic intervention, efficacy of the therapeutic intervention is assessed based on a series of physiologic data associated with the subject. The series of physiologic data is analyzed to produce a measure of complexity. The complexity me... | 02/01/2011 |
| 7846433 | Methods of treating pre-eclampsia and eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 12/07/2010 |
| 7850959 | Methods and compositions for treating conditions involving abnormal angiogenesis The present invention features methods and compositions for preventing, reducing, or treating hypoxia and pathological disorders involving abnormal angiogenesis (e.g., conditions involving decreases or increases in blood flow, respectively). Where an increase in ang... | 12/14/2010 |
| 7837992 | C-1 inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis A mutant prourokinase plasminogen activator (M5) was developed to make prouPA less subject to spontaneous activation during fibrinolysis. C1-inhibitor complexes with tcM5. The effect of C1-inhibitor on fibrinolysis and fibrinogenolysis by M5 was determined. Suppleme... | 11/23/2010 |
| 7794394 | Device for wavelength-selective imaging An imaging device captures both a visible light image and a diagnostic image, the diagnostic image corresponding to emissions from an imaging medium within the object. The visible light image (which may be color or grayscale) and the diagnostic image may be superimp... | 09/14/2010 |
| 7741842 | Calibration maps for parallel imaging free of chemical shift artifact A method for generating a calibrated parallel magnetic resonance image is provided in a manifestation of the invention. A magnetic resonance imaging excitation is applied. A plurality of echoes at different echo times (TE) is acquired. The acquired plurality of echo... | 06/22/2010 |
| 7741310 | Methods for stimulating nervous system regeneration and repair by regulating arginase I and polyamine synthesis This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thu... | 06/22/2010 |
| 7740849 | Use of compounds that bind soluble endoglin and SFLT-1 for the treatment of pregnancy related hypertensive disorders Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin and sFlt-1 expression levels or biological activity. Also disclosed are methods for ... | 06/22/2010 |
| 7662772 | Methods for treating congestive heart failure The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like domain encoded by a neuregulin gene. ... | 02/16/2010 |
| 7638502 | Treatment of EBV and KHSV infection and associated abnormal cellular proliferation A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceu... | 12/29/2009 |
| 7620449 | Differentiating ischemic from non-ischemic T-wave inversion A method of discriminating between ischemic and cardiac memory effects in a heart, comprising receiving electrocardiographic (ECG) data, calculating, from the ECG data, a direction of a T-wave vector, diagnosing ischemia if the T-wave vector is between about 75 degr... | 11/17/2009 |
| 7601124 | Complexity-based dynamical assay for assessing the toxicity and efficacy of pharmaceutical and other therapeutic interventions In a subject undergoing therapeutic intervention, efficacy of the therapeutic intervention is assessed based on a series of physiologic data associated with the subject. The series of physiologic data is analyzed to produce a measure of complexity. The complexity me... | 10/13/2009 |
| 7468030 | Surgical retractor A present invention relates to a surgical retractor that immobilizes tissue at a surgical site. A preferred embodiment of the retractor is used during minimally invasive direct coronary bypass procedures to arrest movement of the grafting site while the heart contin... | 12/23/2008 |
| 7435419 | Methods of diagnosing and treating pre-eclampsia or eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia or a propensity to develop pre-eclampsia or eclampsia by detecting the levels of placental growth factor in a subject. ... | 10/14/2008 |
| 7407659 | Methods of diagnosing pre-eclampsia or eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 08/05/2008 |
| 7394053 | Systems and methods for multi-modal imaging having a spatial relationship in three dimensions between first and second image data The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first d... | 07/01/2008 |
| 7387779 | Anti-angiogenic proteins and fragments and methods of use thereof Proteins with anti-angiogenic properties are disclosed, and fragments thereof, and methods of using those proteins and fragments to inhibit or promote angiogenesis. ... | 06/17/2008 |
| 7364757 | Methods of treating vascular disease The present invention relates to a method of treating patients suffering from, or at risk for, intimal hyperplasia and/or arteriosclerosis. The treatment includes administering a pharmaceutical composition that includes carbon monoxide to the patient. ... | 04/29/2008 |
| 7347995 | Compositions and methods for achieving immune suppression Disclosed herein are therapeutic compositions containing agents that modulate the immune response in a patient. ... | 03/25/2008 |
| 7345021 | Method for PR-39 peptide regulated stimulation of angiogenesis The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homolog, for interaction with such proteasomes as... | 03/18/2008 |
| 7344892 | Screening for gestational disorders The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the ... | 03/18/2008 |
| 7335362 | Methods of treating pre-eclampsia or eclampsia Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the... | 02/26/2008 |
| 7324845 | Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling An assessment of sleep quality and sleep disordered breathing is determined from the cardiopulmonary coupling between two physiological data series. In an embodiment, an R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the... | 01/29/2008 |
| 7297685 | Use of pro-apoptotic factors in treatment of atherosclerosis The present invention features a novel method of treating vascular disease that involves modifying smooth muscle cells to express a gene encoding a protein having both anti-inflammatory and pro-apoptotic activity. Preferably, the protein of the invention also has an... | 11/20/2007 |
| 7288759 | Tissue-like phantoms The invention is based, in part, on the discovery that by combining certain components one can generate a tissue-like phantom that mimics any desired tissue, is simple and inexpensive to prepare, and is stable over many weeks or months. In addition, new multi-modal ... | 10/30/2007 |
| 7258853 | Antagonists of interleukin-15 Disclosed herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient. ... | 08/21/2007 |
| 7238469 | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis The present invention features methods for transplanting organs, tissues and individual cells. Also featured are methods for maintaining cells in vitro and for enhancing survival and/or function of cells following transplantation. The methods include the administrat... | 07/03/2007 |
| 7235049 | Surgical retractor and method of positioning an artery during surgery The present invention relates to a surgical retractor that immobilizes tissue at a surgical site. A preferred embodiment of the retractor is used during minimally invasive direct coronary bypass procedures to arrest movement of the grafting site while the heart cont... | 06/26/2007 |
