Assignee: Berlex Laboratories, Inc.

Location: CedarKnolls, NJ
No. of patents: 21

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Number	Title	Issue Date
5702931	Mutagenesis methods and compositions Methods and reagents for oligonucleotide-directed mutagenesis of a target nucleic acid are provided. In these methods a mutagenic oligonucleotide introduces a desired mutation at one site and, at a second site, introduces or eliminates a restriction site,...	12/30/1997
5669502	Vial holder A vial holder is provided which is easily loaded with a vial, retains the vial in a rigid manner and permits the vial to be discharged in a simple manner. The vial holder can also exhibit two vial retention sections for simultaneously rigidly holding two ...	09/23/1997
5378816	Methods for high purity chromatographic separation of proteins having EGF-like binding domains Proteins having an epidermal growth factor-like binding region, such as thrombomodulin, may be recovered and purified on a anion exchange resin, such as a polyethyleneimine resin. Conditioned medium containing recombinantly produced protein is applied to ...	01/03/1995
5318975	5-pyrimdineamine derivatives This invention relates to novel 5-pyrimidineamine derivatives. The compounds of the invention exhibit cardiovascular properties, particularly mixed vasodilative, selective venous and arterial dilation. Pharmaceutical compositions are proposed for the comp...	06/07/1994
5241415	Heated recording chamber A circular tissue recording chamber has a cavity therein for retaining tissue or cell samples immersed in a liquid bath. The temperature of the bath is maintained at a selected level by a transparent heater positioned beneath the bath, wherein the heater ...	08/31/1993
5215963	Solubilization and purification of the active gastrin releasing peptide receptor A procedure for the preparation of the solubilized and purified gastrin releasing peptide receptor, in an active form, from a gastrin releasing peptide receptor source such as Swiss 3T3 fibroblasts....	06/01/1993
5166344	Process for the preparation of imidazoquinoxalinones This invention relates to novel imidazoquinoxalinones and their aza analogs and to a process for their preparation. The compounds of this invention have been found to have inodilatory, vasodilatory, venodilatory and other pharmacologic effects....	11/24/1992
5082775	Efficient process for isolating insoluble heterologous protein using non-ionic detergents The present invention relates to the isolation and restoration of biological activity to inactive proteins, that is solubilizing, renaturing and restoring activity to proteins which have been partially denatured or inactivated, e.g. during their synthesis...	01/21/1992
5055465	Imidazoquinoxalinones, their aza analogs and process for their preparation This invention relates to novel imidazoquinoxalinones and their aza analogs and to a process for their preparation. The compounds of this invention have been found to have inodilatory, vasodilatory, venodilatory and other pharmacologic effects....	10/08/1991
5017478	Transfected cells containing plasmids having genes oriented in opposing directions and methods of using This invention relates generally to recombinant DNA techniques and to the expression of mammalian polypeptides in genetically engineered eukaryotic cells. Specifically, the invention relates to preferred plasmid constructs and methods that increase levels...	05/21/1991
4966967	3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines as cardiovascular agents This invention relates to novel 3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonines and their pharmaceutically acceptable salts. The compounds of the invention are cardiovascular agents and especially Class III antiarrhythmic agents....	10/30/1990
4937258	Pyrrolo[1,2-c]imidazolone derivatives as PDE inhibitors This invention relates to novel pyrrolo[1,2-c]imidazolones and their pharmaceutically acceptable salts. The compounds of the invention are PDE inhibitors with primarily cardiovascular effects especially cardiotonic effects....	06/26/1990
4817819	Container for tablets A tablet container having a cover and sliding tray is used for dispensing birth control tablets for either a twenty-one-day or twenty-eight-day cycle. Normally, the tray does not slide completely out of the cover and is stabilized with respect thereto whe...	04/04/1989
4743612	Prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-(4-(2-methyl-1H-imidazol-1-yl)benzoyl)-2H-imidazol -2-one, composition containing them, and method of using them to treat cardiac failure Orally active prodrug derivatives of the cardiotonic agent 4-ethyl-1,3-dihydro-5-[4-(2-methyl-1H-imidazol-1-yl)benzoyl]-2H-imidazol-2 -one are disclosed. Pharmaceutical formulations containing such compounds are also provided....	05/10/1988
4693371	Medication dispenser and container A system and apparatus for containing and dispensing medications in a prescribed manner, and for reducing the possibility of incorrect dosages being taken and/or medication being taken at the wrong time of the day. A tray contains plural rows and columns ...	09/15/1987
4663351	Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent A novel, orally administrable pro-drug form of dobutamine of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof....	05/05/1987
4517310	N-[2-hydroxy-2-(3-hydroxyphenyl)ethyl]-1H-benzimidazole-1-butanamine and use thereof as a cardiotonic agent The compound N-[2-hydroxy-2-(3-hydroxyphenyl)ethyl]-1H-benzimidazole-1-butanamine and methods for its manufacture and use are described herein. The compound is a cardiotonic agent useful primarily in the treatment of congestive heart failure....	05/14/1985
4434174	Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines 3-Phenoxy-2-hydroxypropylamines having an N-benzimidazolyalkyl substituent and similar compounds are described herein. They are obtained by the reaction of the appropriate imidazole-1-alkanamine with an epoxide, and they are useful primarily as ଲ	02/28/1984
4415587	Method of use of antiarrhythmic 1-arylcarbamoylalkyl imidazole derivatives, composition Novel 1,2-disubstituted imidazol(in)es are described herein. The compounds are generally produced by reacting a haloacylanilide with an excess of 2-substituted-imidazol(in)e. The compounds are antiarrhythmic agents....	11/15/1983
4363808	N-(3-Phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines 3-Phenoxy-2-hydroxypropylamines having an N-benzimidazolyalkyl substituent and similar compounds are described herein. They are obtained by the reaction of the appropriate imidazole-1-alkanamine with an epoxide, and they are useful primarily as ଲ-ad...	12/14/1982
4353921	Antiarrythmic 1-arylcarbamoylalkyl-2-imidazoline derivatives, composition and method of use Novel 1,2-disubstituted imidazol(in)es are described herein. The compounds are generally produced by reacting a haloacylanilide with an excess of 2-substituted-imidazol(in)e. The compounds are antiarrhythmic agents....	10/12/1982

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Assignee: Berlex Laboratories, Inc.