Assignee: Behringwerke AG

Location: Marburg, DE
No. of patents: 40

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Number	Title	Issue Date
6294323	Self initiating single primer amplification of nucleic acids A method is disclosed for producing at least one copy of a pair of complementary single stranded polynucleotides. The method comprises forming, in the presence of nucleoside triphosphates and template dependent polynucleotide polymerase along each of the ...	09/25/2001
6124090	Nucleic acid amplification using single primer A method is disclosed for determining the presence of a polynucleotide analyte in a sample suspected of containing the analyte. The method comprises (a) forming as a result of the presence of an analyte a single stranded polynucleotide comprising a target...	09/26/2000
6090567	Homogeneous immunoassays using mutant glucose-6-phosphate dehydrogenases Methods for immunoassay of analytes employing mutant glucose-6-phosphate dehydrogenase (G6PDH) enzymes as labels. In particular, the invention relates to the use of conjugates of an analyte or analyte analog and a mutant NAD+ dependent G6PDH d...	07/18/2000
5985550	Double receptor polynucleotide assay method A method for the detection of a polynucleotide target sequence is described. The method involves the formation of a covalent or non-covalent bonded pair of nucleotide sequences formed in response to a target polynucleotide sequence, adding nucleotide sequ...	11/16/1999
5981227	Process for the production of proteins The invention pertains to the field of recombinant DNA technology and concerns a method for the production of a protein heterologous to yeast in a homogeneous form with the aid of Saccharomyces cerevisiae strain HT393 or a derivative thereof carrying a hy...	11/09/1999
5882857	Internal positive controls for nucleic acid amplification The present invention relates to an improvement in a method for amplifying a target sequence of a target polynucleotide. The method comprises combining a sample suspected of containing the target polynucleotide with reagents for amplifying the target sequ...	03/16/1999
5807675	Fluorescent oxygen channeling immunoassays Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte, if present, causes a photosensitizer and a ...	09/15/1998
5780646	Cyclic ether compounds Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond s...	07/14/1998
5686253	Method of stabilizing enzyme conjugates A method is disclosed for stabilizing a conjugate of an enzyme and a member of a specific binding pair (enzyme conjugate). The method comprises the step of combining the enzyme conjugate with an effective amount of an antibody for the enzyme where the ant...	11/11/1997
5683879	Methods for producing a single stranded polydeoxynucleotide having two different defined sequences and kits A method is disclosed for extending a primer to produce a single stranded polydeoxynucleotide that has two or more defined sequences. A combination is provided which comprises a template polynucleotide, a blocker polynucleotide, a primer polynucleotide an...	11/04/1997
5679512	Method for introducing defined sequences at the 3'end of polynucleotides A method is disclosed for extending a primer to produce a single stranded polydeoxynucleotide that has two or more defined sequences. A combination is provided which comprises a template polynucleotide, a blocker polynucleotide, a primer polynucleotide an...	10/21/1997
5672478	Methods of use for and kits containing chemiluminescent compounds Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) combining a medium suspected of containing the analyte and a novel chemiluminescent compound, (2) combining a means for ch...	09/30/1997
5670690	Compositions and methods for removal of detergents Compounds having detergent properties are disclosed. When a modifying reagent is brought into contact with these compounds, the detergent properties are decreased. These compounds are useful, for example, as solubilizing agents for microbial antigens and/...	09/23/1997
5656269	Peptide plasminogen activators Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, reduced fibrin stimulation of plasminogenolytic activity...	08/12/1997
5637467	Heterogeneous assay using a pendulous drop As method of determining an analyte is described, where a medium suspected of containing an analyte is drawn into a capillary tube by capillary action, such that if the analyte is present, it becomes immobilized in the tube. This medium is expelled from t...	06/10/1997
5629157	Double receptor polynucleotide assay method A method for the detection of a polynucleotide target sequence is described. The method involves the formation of a covalent or non-covalent bonded pair of nucleotide sequences formed in response to a target polynucleotide sequence, adding nucleotide sequ...	05/13/1997
5624809	Device for immunochromatographic analysis Methods are disclosed for conducting assays. One such method comprises providing in combination a first bibulous member zone ("first zone") and a liquid medium containing a component. The first zone has non-diffusively bound thereto a reagent interreactiv...	04/29/1997
5622870	Device and method for completing a fluidic circuit Disclosed are assay apparatus, devices and methods that permit longitudinal capillary flow of liquid between two pieces of bibulous material which, prior to actuation, are in a non-capillary flow relationship to each other. In particular, the devices util...	04/22/1997
5620657	Device and method for completing a fluidic circuit Disclosed are assay apparatus, devices and methods that permit longitudinal capillary flow of liquid between two pieces of bibulous material which, prior to actuation, are in a non-capillary flow relationship to each other. In particular, the devices util...	04/15/1997
5618732	Method of calibration with photoactivatable chemiluminescent matrices Methods for labeling a material are disclosed. The methods comprise combining with the material (a) a photosensitizer capable upon irradiation of generating singlet oxygen and (b) a chemiluminescent compound capable of being activated by singlet oxygen wh...	04/08/1997
5616719	Photoactive indicator compounds Photoactive indicator compounds of the formula ##STR1##...	04/01/1997
5612199	Method for producing a polynucleotide for use in single primer amplification A method is disclosed for extending an extender probe to produce a single stranded polydeoxynucleotide that is free of unreacted extender probe and has two segments that are non-contiguous and complementary with each other. The method comprises the steps ...	03/18/1997
5605796	Method for preventing amplification of nucleic acid contaminants in amplification mixtures using nuclease-receptor conjugates Methods and kits are disclosed for preventing amplification of contaminating copies of nucleic acids during in amplification of a nucleic acid suspected of being present in a sample. Modified nucleotides that render copies of the nucleic acid bindable by ...	02/25/1997
5595891	Method for producing a polynucleotide for use in single primer amplification A method is disclosed for producing a single stranded polydeoxynucleotide having two segments that are non-contiguous and complementary with each other. The method comprises the steps of providing in combination (1) a polynucleotide having two non-contigu...	01/21/1997
5591640	Functional DNA block and plasmid coding for hirudin, transformed yeast, method for preparing hirudin, hirudin obtained and its pharmaceutical use The invention relates to a functional DNA block by means of which hirudin may be prepared from yeast, which block contains at least the sequence: --Str --Lex --Scl --H gene H gene being the gene coding for hirudin or one of its vari...	01/07/1997
5578498	Metal chelate containing compositions for use in chemiluminescent assays Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond s...	11/26/1996
5563038	Compositions and methods for removal of detergents Compounds having detergent properties are disclosed. When a modifying reagent is brought into contact with these compounds, the detergent properties are decreased. These compounds are useful, for example, as solubilizing agents for microbial antigens and/...	10/08/1996
5561119	Glycosylated prodrugs, their method of preparation and their uses Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I). ##STR1##...	10/01/1996
5561049	Method for detecting antibodies This invention pertains to methods to detect antibodies in a sample. The methods use an amount of antigen that is up to 1000, preferably 10-100 times the minimum amount antigen that can be reliably detected and that is less than the maximum expected amoun...	10/01/1996
5545834	Chemiluminescent compounds and methods of use Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) combining a medium suspected of containing the analyte and a novel chemiluminescent compound, (2) combining a means for ch...	08/13/1996
5536644	Particle separation method A method is disclosed for separating a substance from a liquid medium. The method comprises combining the liquid medium containing the substance with magnetic particles under conditions for non-specific chemical binding of the magnetic particles. Thereaft...	07/16/1996
5536834	Cyclic ether compounds Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a hexacoordinated state and (b) a compound having a double bond s...	07/16/1996
5532138	Method and kits for determining peroxidatively active catalysts Methods and compositions are disclosed for determining a peroxidatively active catalyst. The methods comprise the step of detecting a substance formed by the coupling reaction of (a) the product of the peroxidatively active catalyst-catalyzed oxidation of...	07/02/1996
5525717	Support-bound nucletide probe for neisseria gonorrhoeae A nucleotide sequence characteristic of Neisseria gonorrhoeae is disclosed. The sequence can be the basis for hybridization type, nucleic acid-based, rapid, in vitro diagnostic assays. The unique nature of the sequence makes it possible to clearly discrim...	06/11/1996
5501853	Peptide plasminogen activators Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibiti...	03/26/1996
5439679	Peptide plasminogen activators Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, enhanced specific activity, reduced response to inhibiti...	08/08/1995
5287758	Temperature controlled pipette tube A heatable pipette apparatus, includes a pipette tube having a first zone and second zone. The first zone includes a tip end and a first heater for heating the first zone. The second zone includes a second heater for heating the second zone. Regulators ar...	02/22/1994
4411988	Process for the determination of anti-hyaluronidase and an agent suitable for this purpose A simple rapid assay for the determination of antihyaluronidase and a kit for use therein. The assay is based on the precipitation of unreacted hyaluronic acid by a cationic detergent and acid dyestuff. The assay is preferably performed as a dilution seri...	10/25/1983
4269825	New glycoprotein and process for isolating it A new glycoprotein is characterized by a protein consisting essentially of 75&#b1;6% of ଱-amino-acids, a carbohydrate portion of 24.6&#b1;5.2%, which contains 8.9&#b1;2% of hexoses, 7.1&#b1;1.5 of N-acetylated hexosamine, 0.2&#b1;0.2% of fucose, 8.4...	05/26/1981
4011142	Process for measuring the plasminogen content of a sample The plasminogen content of a blood sample is measured by determining the rate of formation of fibrin in a sample in which antiplasmin-free plasminogen is activated to form plasmin before the onset of fibrin formation so that the plasmin-conditioned break-...	03/08/1977

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Assignee: Behringwerke AG