Assignee: Beecham Group p.l.c.

Location: Brentford, GB2
No. of patents: 110

Browse patents
Browse applications

Number	Title	Issue Date
6964865	Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for β-lactam antibiotic biosynthesis DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthe...	11/15/2005
6709859	Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthe...	03/23/2004
6686475	Compounds Compounds of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl group;...	02/03/2004
6531600	Treatment and compounds A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): ##STR1## or if...	03/11/2003
6180791	Synthesis of 8-substituted xanthines A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): ##STR1## or if...	01/30/2001
6136813	Pharmaceutical treatment Pharmaceutical use of a compound of formula (A): ##STR1## or a pro-drug, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing; in the treatment of hepatitis B virus infections....	10/24/2000
6077536	Pharmaceutical formulation A pharmaceutical formulation comprising an amoxycillin hydrate and an effervescent couple, for example citric acid plus sodium bicarbonate or sodium glycine carbonate, or tartaric acid or malic acid plus sodium carbonate. Potassium equivalents of these so...	06/20/2000
6066468	Chromosomal DNA fragments encoding enzymes for encoding ଲ-lactam biosynthetic enzymes, and vectors and transformants for their expression DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthesis...	05/23/2000
6037156	DNA molecules and vectors encoding clavulanic acid biosynthesis enzymes DNA sequences obtained from S. clavuligerus, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes encoding one or more enzymes involved in the biosynthesis of clavulani...	03/14/2000
5792790	Method for improving weight gain and feed utilization in livestock Crystalline calcium pseudomonate or a hydrate thereof, in particular the dihydrate. Processes for the preparation of these salts and their use in human and veterinary medicine and as a growth promoter in animals are described....	08/11/1998
5759831	DNA molecules and vectors regarding clavulanic acid biosynthesis enzymes DNA sequences obtained from S. clavuligerus, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes encoding one or more enzymes involved in the biosynthesis of clavulani...	06/02/1998
5756525	Compounds for treating eating disorders A method is provided for the treatment and/or prophylaxis of cardiovascular diseases or eating disorders in a human or non-human mammal, which comprises administering to a human or non-human mammal in need thereof, an effective, non-toxic amount of a comp...	05/26/1998
5734051	8-substituted xanthine derivatives and method of use thereof A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): ##STR1## ...	03/31/1998
5684153	Process for the preparation of purine derivatives The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting the compound 2-amino-6-chloropurine (ACP) with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate, followed by displacement of the 6-chloro moiety ...	11/04/1997
5679789	Pharmaceutical compositions comprising potassium clavulanate and methods of using them Potassium clavulanate exists in a novel crystalline habit, namely in the form of rosettes, having improved processing properties. The novel form may, for example, be obtained by crystallization or recrystallization using inverse precipitation, preferably ...	10/21/1997
5674869	Pharmaceutical treatment Use of a guanine derivative or a prodrug thereof in the treatment of viral infections....	10/07/1997
5670170	Pharamaceutical formulation A pharmaceutical formulation comprises a medicament and an effervescent couple, plus optionally other excipients. Preferred medicaments are antibiotics, together with a citric acid--sodium bicarbonate couple. The formulation is provided for make up with w...	09/23/1997
5569672	Compounds Crystalline calcium pseudomonate or a hydrate thereof, in particular the dihydrate. Processes for the preparation of these salts and their use in human and veterinary medicine and as a growth promoter in animals are described....	10/29/1996
5554610	Inhalational treatment of pulmonary hypertension and related conditions A method for the treatment and/or prophylaxis of disorders associated with pulmonary hypertension and/or disorders associated with right heart failure, in mammals, such as humans, which method comprises administering to the mammal in need of such treatmen...	09/10/1996
5521201	Method for treatment of atherosclerosis A method is provided for the treatment and/or prophylaxis of cardiovascular diseases in a human or non-human mammal, which comprises administering to a human or non-human mammal in need thereof, an effective, non-toxic amount of a compound of formula (I):...	05/28/1996
5436266	Compounds Crystalline calcium pseudomonate or a hydrate thereof, in particular the dihydrate. Processes for the preparation of these salts and their use in human and veterinary medicine and as a growth promoter in animals are described....	07/25/1995
5391565	Oxazolidine dione derivatives Compounds of the formula: ##STR1## or tautomeric forms and a pharmaceutically acceptable salt, and pharmaceutically acceptable solvates thereof, wherein: A1 is a substituted or unsubstituted oxazole substituted by up to 4 substituents sele...	02/21/1995
5264436	Heterocyclic compounds which have useful pharmaceutical utility A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein: Z represents a residue of a substituted or unsubstituted aryl group, A1 represents a s...	11/23/1993
5260445	2,4-thiazolidinediones Compounds of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl g...	11/09/1993
5252575	Antiviral purine derivatives with improved gastrointestinal absorption Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R1 is hydrogen or hydroxy; and R2 is C1-6 alkyl; which are pro-drugs for 9-(3-hydroxyprop-1-oxy)guanine having antiviral activity, a ...	10/12/1993
5247085	Antiviral purine compounds Compounds of formula (I), and pharmaceutically acceptable salts thereof ##STR1## wherein R1 is hydroxy, amino, chloro or OR7 wherein R7 is C1-6 alkyl, phenyl or phenyl C1-2 alkyl either of which pheny...	09/21/1993
5232925	Compounds Compounds of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl g...	08/03/1993
5220024	Process for the preparation of purine derivatives as antiviral agents A process for the preparation of a compound of formula (A): ##STR1## wherein X is hydrogen, hydroxy, chloro, C1-6 alkoxy or phenyl C1-6 alkoxy and Ra and Rb are hydrogen, including acyl and phosphate deriva...	06/15/1993
5217975	Azabicyclic compounds for treating dementia A compound of formula (I) useful for treating dementia or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents Z, where Z is a group in which Q represents a 3-membered divalent res...	06/08/1993
5204330	Antifungal compounds A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R1 is a group --CH2 --X where X is hydrogen, halogen, --CN, --N3, --OC(O)R5, --S(O)n R5, --SH, ...	04/20/1993
5194443	Compounds Compounds of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, wherein: A1 represents a substituted or unsubstituted aromatic heterocyclyl g...	03/16/1993
5190937	Lactam derivatives Novel compounds of formula (I), and pharmaceutically acceptable salts thereof; their preparation; compositions containing them; and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of th...	03/02/1993
5175288	Process for preparing purine derivatives and intermediates thereof A process for preparing pharmaceutically active compounds of formula (A): ##STR1## wherein X is hydrogen, hydroxy, chloro, C1-6 alkoxy or phenyl C1-6 alkoxy; and Ra and Rb are hydrogen, or acyl or phosphate...	12/29/1992
5166198	Antiviral phosphonylalkoxy purines A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 is hydroxy or amino; R2 is hydrogen or amino; R3 is hydrogen, hydroxymethyl or acyloxymethyl; R4 is hydrogen or (when R	11/24/1992
5159076	Purine intermediates Compounds of formula (II): ##STR1## wherein R4 ' is R4 wherein R4 is hydrogen, hydroxy, amino or OR5 wherein R5 is C1-6 alkyl, phenyl or phenyl C1-2 alkyl either of which phenyl ...	10/27/1992
5157160	Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their pharmaceutical use A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which Z is a heterocyclic group ##STR2## in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises one or two hete...	10/20/1992
5153210	Compounds A compound of the general formula (I): ##STR1## or a pharmaceutically acceptable ester thereof; or a pharmaceutically acceptable salt thereof, wherein, Ro represents a substituted or unsubstituted aryl group or a substituted or unsubstitut...	10/06/1992
5138057	Chemical process for the preparation of purine derivatives A process for the preparation of a compound of formula (I) ##STR1## which process comprises reacting a compound of formula (II): ##STR2## wherein the amino group is optionally protected, with a side chain intermediate of formula (III): ##ST...	08/11/1992
5132466	Process for preparing 4-(6-methoxy-2'-naphthyl)butane-2-one A process for the preparation of a compound of formula (I): ##STR1## in which X and Y are identical and represent halogen, or X is halogen and Y is hydrogen, which comprises halogenating 2-methyl-6-methoxynaphthalene, of formula (II): ##STR2## ...	07/21/1992
5110828	Azabicyclo oxime derivatives Novel compounds of formula (I), a process for their preparation, and their use as pharmaceutical agents are described: ##STR1## wherein R1 represents ##STR2## in which each of p and q independently represents an integer of 2 to 4, r ...	05/05/1992

«First «Previous1 2 3 Next»Last»

PatentStorm

Quotables

PatentStorm News

Assignee: Beecham Group p.l.c.