Assignee: Beckman Coulter, Inc.

Location: Fullerton, CA
No. of patents: 216

Number	Title	Issue Date
8064062	Photometric apparatus and automatic analyzer A photometric apparatus and an automatic analyzer in which liquid samples contained in vessels are measured with light of different wavelengths while the vessels are transferred are provided. A photometric apparatus includes light sources that are arranged in the mo...	11/22/2011
8023592	Method and apparatus for finding center amplitude of particle size-representative pulses produced by aperture based sizing system Pipelined digital processing circuitry for use with a particle size measurement system, such as that employed in automated hematology systems, measures the ‘center’ amplitude of a pulse produced by a particle or cell passing through a flow cell measurement apert...	09/20/2011
8000940	Shape parameter for hematology instruments Systems, methods, and computer program products are provided for describing characteristics of a data sample. This description is used to represent the shape of a histogram of the data sample. ...	08/16/2011
7998409	Specimen-transport module for multi-instrument clinical workcell A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an...	08/16/2011
7981383	Latch system and modified blade design for thick stopper-closed container sampling piercing station A piercing station for piercing sample container caps or thick stoppers is provided. The cap piercing station utilizes a piercing blade having a generally Z-shape cross-section, a carriage assembly for moving the blade to pierce a cap on a container, an alignment bl...	07/19/2011
7910074	System and method for continuously transferring and processing liquids A liquid transfer system for transferring liquid from a plurality of containers to a plurality of destinations comprises a plurality of inlet valves. Each inlet valve is operable between an open position allowing liquid from a container to be drawn into the system a...	03/22/2011
7857955	Coated capillary electrophoresis tubes and system The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to the inner capillary surface. The capillary tube has an inner surface th...	12/28/2010
7854892	Specimen-transport module A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an...	12/21/2010
7850914	Specimen-transport module for a multi-instrument clinical workcell A specimen-transport module adapted for use with each of a plurality of specimen-processing instruments of a multi-instrument clinical workcell. Such module is adapted to transport individual racks of specimen-containers relative to a specimen-aspiration probe of an...	12/14/2010
7838481	Formaldehyde-free cleaner composition for cleaning blood analyzers and method of use A formaldehyde-free cleaner composition and method of use for maintaining a blood analyzer are disclosed. The cleaner composition includes surfactants, a proteolytic enzyme, non-formaldehyde releasing antimicrobials, alkaline metal salts, and a buffer. The cleaner c...	11/23/2010
7803523	Whole blood preparation for cytometric analysis of cell signaling pathways This invention is directed to a method for preparation of a biological sample for measurement of protein epitopes that allows for the preservation of intracellular protein epitopes and detection of signal transduction pathways based on the ability to capture transie...	09/28/2010
7754487	Hematology linearity control composition, system and method of use A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositi...	07/13/2010
7691636	Method and apparatus for compensating for variations in particle trajectories in electrostatic sorter for flowcell cytometer A flow cytometer subsystems monitors a particle sensing zone within a fluid transport chamber for the presence of a particle (e.g., blood cell) traveling therethrough, and produces an output pulse, whose width is representative of the trajectory and thereby the leng...	04/06/2010
7678578	Cell permeabilization and stabilization reagent and method of use A cell permeabilization and stabilization reagent and method of use are disclosed. The reagent contains a N-acyl sarcosine or a salt thereof, a pH adjusting agent to adjust pH of the reagent in a range from about 4 to about 6; and an aqueous medium; the reagent havi...	03/16/2010
7678379	epitopes and methods of use thereof The invention provides novel Class I HLA-A2 and Class II HLA-DR4-restricted epitopes and methods for their use in detecting T-cells in peripheral blood specific for infection or latency of mycobacterial infection, including M. tuberculosis and M. leprae	03/16/2010
7674598	Method for a fully automated monoclonal antibody-based extended differential Methods for differentially identifying cells in an instrument employ compositions containing a combination of selected antibodies and fluorescent dyes having different cellular distribution patterns and specificities, as well as antibodies and fluorescent dyes chara...	03/09/2010
7662339	Apparatus having improved gantry assembly suitable for use in a laboratory environment An assembly suitable for use in a laboratory instrument is set forth. The assembly comprises a plurality of guide rods that are disposed generally parallel with one another and a plurality of carriage assemblies connected for movement along the plurality of guide ro...	02/16/2010
7661326	Apparatus for aspirating and dispensing liquids in an automated analyzer Apparatus for aspirating and dispensing liquid samples in an analytical instrument, e.g., a hematology instrument, includes a liquid-sampling valve that, while operating to segment and position for dispensing one or more precise volumes of a liquid sample that has b...	02/16/2010
7651858	Ion-detecting microspheres This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream...	01/26/2010
7625761	Flexible reactor A reaction vessel and a reaction system having an annular tube with an inlet, an outlet, and at least one expandable section between the inlet and the outlet. The expandable section of the annular tube has a first shape and a second expanded shape. The expandable se...	12/01/2009
7625712	Method for a fully automated monoclonal antibody-based extended differential A method useful for the enumeration of cell populations in a biological sample includes the steps of reacting in a single reaction mixture a sample, a first antibody labeled with a fluorochrome having a first emission spectrum and an additional antibody. The first a...	12/01/2009
7613583	Method and system for particle data processing In an embodiment, a computer-implemented method is provided for processing digital data from a particle analyzer. The method includes receiving digital particle data, transforming the received data to correct for noise, applying linear compensation for dye spectral ...	11/03/2009
7609369	Methods of detection of iron deficiency and hemochromatosis New diagnostic parameters or indexes for detection of absolute iron deficiency, latent iron deficiency, functional iron deficiency, or latent functional iron deficiency have been disclosed. The parameters include a RBC size factor, RSf1 defined by the for...	10/27/2009
7597845	Apparatus for selectively holding and releasing an object in an analysis system An apparatus for selectively holding and releasing an object in an analysis system is set forth. The apparatus comprises first and second arm assemblies that are mounted for rotation about a corresponding pair of axes. Each arm assembly includes an object holding en...	10/06/2009
7590500	System for high dynamic range analysis in flow cytometry A flow cytometer capable of using electronics to analyze a large dynamic range while avoiding and/or correcting traditional limitations of acquisition electronics. The invention allows for measuring signal characteristics, which may include but are not limited to li...	09/15/2009
7586589	Methods of determination of responsiveness to erythropoietin treatment Methods for determining the responsiveness of a patient to recombinant human erythropoietin therapy are disclosed. In one approach, the method includes obtaining a volume-Hgb factor (VHf) defined as a product function of MCV and Hgb from a patient's blood sample; co...	09/08/2009
7585466	Automatic genotype determination Genotypes of a subject may be determined by analyzing a biological sample. Measurements of the intensity of allele specific signals may be obtained and used to generate reaction values. These reaction values may be compared to probability distributions in order to o...	09/08/2009
7556932	Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection The invention provides highly sensitive and rapid homogeneous assays which employ particle-enhanced assay formats in concert with capillary electrophoresis and laser-induced fluorescence (LIF) detection to determine the concentration of an analyte of interest in a s...	07/07/2009
7556177	Slide ejector mechanism suitable for use in a laboratory instrument A slide ejector mechanism for automatically removing a slide from a slide stack is set forth. The slide ejector mechanism comprises an ejector blade adapted to engage a longitudinal edge of the slide and an ejector drive. The ejector drive is connected to rotate the...	07/07/2009
7546936	Liquid aspiration device and method A liquid aspiration device comprises an aspiration tube that slideably engages an opening in a cap such that a head on the end of the aspiration tube is moveable with respect to the opening in the cap. A tube cover is positioned between the opening in the cap and th...	06/16/2009
7541190	Method of measurement of cellular hemoglobin A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a ne...	06/02/2009
7534395	Hysteresis compensation system A system and method for compensating for hysteresis in laboratory liquid handling apparatus. The system comprises a carriage holding a drive gear that meshes with and drives a gear rack. A hysteresis brake is also provided on the carriage and opposes the movement of...	05/19/2009
7527300	Flexible tubing connector A connector for use in securing a length of flexible tubing with another object is set forth. The connector comprises a fitting and a collar. The fitting includes a neck that is adapted to receive the flexible tubing thereon. The neck, in turn, includes an exteriorl...	05/05/2009
7518727	Multicapillary multilaser detection system A system for detecting electromagnetic radiation from samples comprising: a plurality of sample volumes, each of said sample volumes confined within a portion of a capillary column; a plurality of electromagnetic radiation sources; a mirror for receiving electromagn...	04/14/2009
7510684	Latch system and modified blade design for thick stopper-closed container sampling piercing station A piercing station for piercing sample container caps or thick stoppers is provided. The cap piercing station utilizes a piercing blade having a generally Z-shaped cross-section, a carriage assembly for moving the blade to pierce a cap on a container, an alignment b...	03/31/2009
7494776	Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands Methods for determining the presence of an analyte in a sample are disclosed, in which a capture agent is bound to the analyte at a first epitope and a detection agent is bound at a second epitope, and in which the detection agent includes an oligonucleotide to whic...	02/24/2009
7491364	Method and system for transporting and storing multiple reagent packs and reagent packs used therein A new method and system for transporting and sorting multiple reagent packs used in conjunction with an immunodiagnostic instrument is provided. The new system includes a multiplicity of reagent packs; a gantry movably mounted on a rack structure for carrying a grip...	02/17/2009
7488450	Analyte collection and detection devices A system for collecting biological samples, such as fecal specimens, and testing such samples for the presence of an analyte is disclosed. The system comprises a sample collection device that includes a removably secured tab for retaining and transferring a portion ...	02/10/2009
7482165	Method of preventing white blood cell interferences to red blood cell measurements of a blood sample Methods of prevention and correction of white blood cell interferences to the measurements of mean cell volume (MCV), red blood cell concentration (RBC) and hematocrit (Hct) of a blood sample are disclosed. The interference to MCV can be prevented by identifying a v...	01/27/2009
7481978	Apparatus for aspirating liquids from sealed containers Apparatus for aspirating liquid from a container, e.g., a test tube, having a puncturable stopper includes a pair of stepper motors that share a common linear actuator or drive member. One motor operates to axially advance the linear drive member (preferably a lead ...	01/27/2009

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Assignee: Beckman Coulter, Inc.