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| Number | Title | Issue Date |
| 8173696 | Inhibitors of cysteine proteases and methods of use thereof The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhi... | 05/08/2012 |
| 8026483 | Spectroscopic determination of sucrose A method for determining sugar concentration using spectropolarimetry and multivariate regression modeling A set of fixed polarizers are used in association with a spectrometer, which enables the measurement of optical rotation as absorbance values over a range of w... | 09/27/2011 |
| 7998925 | Spatially-defined modification of fresh tissue using covalent chemistry Methods for modification of tissue using covalent chemistry. Tissue can be modified through direct alkylation, reduction followed by alkylation, or oxidation followed by condensation to covalently attach small organic molecules or appropriately modified proteins. Th... | 08/16/2011 |
| 7911608 | Spectroscopic determination of enantiomeric purity A new method and strategy for the quantitative determination of enantiomeric purity that combines polarimetry, spectroscopy, and chemometric modeling. Spectral data is collected after a light beam is passed through a first polarimeter, a sample of a chiral compound,... | 03/22/2011 |
| 7893261 | Serotonin reuptake inhibitors A serotonin reuptake inhibitor which can be used in the treatment of depression and which has a decreased occurrence of unwanted side effects. The serotonin reuptake inhibitors are bi-functional organic molecules which combine serotonin transporter reuptake inhibiti... | 02/22/2011 |
| 7653494 | Method and machine for identifying a chemical compound The present invention is designed to efficiently calculate isotopic distribution in order to simulate mass spectra data for any chemical compound of interest. The simulated spectra considers the various isotopes of the compound based upon a probability calculation t... | 01/26/2010 |
| 7481752 | Abdominal exercise machine An exercise machine, more specifically, an abdominal exercise machine. The abdominal exercise machine consists of a frame upon which the user sits, the frame having a support arm tilted backward from vertical with the lower lumbar region against a seat member. Pivot... | 01/27/2009 |
| 7456214 | Chromene-containing compounds with anti-tubulin and vascular targeting activity Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. ... | 11/25/2008 |
| 7429681 | Combretastatin analogs with tubulin binding activity Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain o... | 09/30/2008 |
| 7384925 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 06/10/2008 |
| 7206700 | Method and machine for identifying a chemical compound The present invention is designed to efficiently calculate isotopic distribution in order to simulate mass spectra data for any chemical compound of interest. The simulated spectra considers the various isotopes of the compound based upon a probability calculation t... | 04/17/2007 |
| 7191070 | Methods for determining enantiomeric purity A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression mode... | 03/13/2007 |
| 7091240 | Tubulin binding ligands and corresponding prodrug constructs A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin... | 08/15/2006 |
| 7001926 | Tubulin binding agents and corresponding prodrug constructs A diverse set of tubulin binding agents have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl-aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin... | 02/21/2006 |
| 6956054 | Compositions and methods for use in targeting vascular destruction Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels a... | 10/18/2005 |
| 6919324 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 07/19/2005 |
| 6849656 | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the trea... | 02/01/2005 |
| 6774368 | Dispersive near-infrared spectrometer with automatic wavelength calibration The present invention is a dispersive, diffraction grating, NIR spectrometer that automatically calibrates the wavelength scale of the instrument without the need for external wavelength calibration materials. The invention results from the novel combination of: 1) ... | 08/10/2004 |
| 6593374 | Tubulin binding ligands and corresponding prodrug constructs A diverse set of tubulin binding ligands have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl--aryl, pseudo pi stacking distances appropriate for molecular recogniti... | 07/15/2003 |
| 6287818 | Method for synthesis of N-homocysteine thiolactonyl retinamido cobalamin and uses thereof The present invention describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.... | 09/11/2001 |
| 6280772 | Polyester/carboxylic acid composite materials The present invention involves an aspirin/polyglycolide complex, its preparation and use. The complex provides a stable aspirin source, slowly releasing aspirin by dissociation or during polyglycolide degradation in vivo.... | 08/28/2001 |
| 6274742 | Method for synthesis of N-homocysteine thiolactonyl retinamide The present invention describes a method of organic synthesis for N-homocysteine thiolactonyl retinamide, a compound that has anticancer and antiatherogenic properties.... | 08/14/2001 |
| 6162930 | Anti-mitotic agents which inhibit tubulin polymerization Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described.... | 12/19/2000 |
| 6054595 | Method for synthesis of N-homocysteine thiolactonyl retinamide The present invention describes a method of organic synthesis for N-homocysteine thiolactonyl retinamide, a compound that has anticancer and antiatherogenic properties.... | 04/25/2000 |
| 6011133 | Laminates of glass or metal and poly(alkylene dicarboxylates) and syntheses thereof Poly(alkylene dicarboxylate) polymers and copolymers having tetraalkyl- or trialkylammonium ion end groups and methods of synthesis, thereof. The methylene-containing copolymers, in general, adhere to glass and metals, including aluminum, iron, and copper... | 01/04/2000 |
| 5886025 | Anti-mitotic agents which inhibit tubulin polymerization Methoxy and ethoxy substituted 3-aroyl-2-arylbenzob!thiophenes and benzob!thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described.... | 03/23/1999 |
| 5876631 | Fluorinated organic gelation agents The present invention generally relates to the formation of organic gels by dissolving organic gelling agents in organic solvents. The aryl cyclohexanol gelling agents employed in this invention are not structurally related to previously known gellation a... | 03/02/1999 |
| 5855915 | Tablets or biologically acceptable implants for long-term antiinflammatory drug release The present invention involves an aspirin/polyglycolide complex, its preparation and use. The complex provides a stable aspirin source, slowly releasing aspirin by dissociation or during polyglycolide degradation in vivo.... | 01/05/1999 |
| 5696378 | High accuracy determination of chlorine content by isotope dilution flame infrared emission spectrometry (ID-FIRE) A method and apparatus for quantitatively determining chlorine content and fractional abundance of chlorine isotopes in unknown samples. When using this method and apparatus to determine chlorine content, isotope dilution principles may be employed. Chlor... | 12/09/1997 |
| 5688440 | Organic gellation agents The present invention generally relates to the formation of organic gels by dissolving organic gelling agents in organic solvents. The aryl cyclohexanol gelling agents employed in this invention are not structurally related to previously known gellation a... | 11/18/1997 |
| 5561212 | Poly(methylene oxalate), a new composition of matter A poly(methylene oxalate) polymer, [poly(oxy(1,2-dioxo-1,2-ethanediyl)oxymethylene)], a bis(tetrabutylammonium) oxalate salt, methods of synthesis thereof and methods of use are provided. Poly(methylene oxalate) is nearly insoluble in all common orga... | 10/01/1996 |
| 5556100 | Game of the immune system The present invention provides a board game for use as a didactic teaching-aid for individuals that are interested in the immune system. The game comprises a playing board having a continuous main course having a plurality of playing spaces. Each playing ... | 09/17/1996 |
| 5473162 | Infrared emission detection of a gas Apparatus and method for qualitatively and quantitatively analyzing infrared emission from excited molecules in the determination of, for example, total inorganic carbon, chloride and available chlorine in aqueous samples. Methods of exciting the gas-phas... | 12/05/1995 |
| 5451643 | Poly(alkylene dicarboxylates) and synthesis thereof Poly(alkylene dicarboxylate) polymers and copolymers having tetraalkyl- or trialkylammonium ion end groups and methods of synthesis, thereof. The methylene-containing copolymers, in general, adhere to glass and metals, including aluminum, iron, and copper... | 09/19/1995 |
| 5426218 | Bis (tetraalkylammonium) oxalate A poly(methylene oxalate) polymer [poly(oxy(1,2-dioxo-1,2-ethanediyl)oxymethylene)], a bis(tetrabutylammonium)oxalate salt, methods of synthesis thereof and methods of use. Poly(methylene oxalate) is insoluble in all common organic solvents, does not... | 06/20/1995 |
| 5371171 | Poly(methylene oxalate) and precursors thereto A poly(methylene oxalate) polymer [poly(oxy(1,2-dioxo-1,2-ethanediyl)oxymethylene)], a bis(tetrabutylammonium) oxalate salt, methods of synthesis thereof and methods of use. Poly(methylene oxalate) is insoluble in all common organic solvents, does no... | 12/06/1994 |
| 5342772 | Process for enzyme immobilization on a fluorocarbon surface The fluorocarbon surface of a solid or liquid support is activated with a highly fluorinated isocyanate-modified ligand or with a reactive poly(fluoroalkyl) sugar reagent containing a polyhydroxy sugar to which are attached a plurality of fluoroalkyl anch... | 08/30/1994 |
| 4494872 | Multiple entrance aperture dispersive optical spectrometer A dispersive optical spectrometer is disclosed which comprises light detection means, dispersion means for separating light radiation into spectral components and for directing the spectral components toward the light detection means, means for admitting ... | 01/22/1985 |
| 4375919 | Multiple entrance aperture dispersive optical spectrometer A dispersive optical spectrometer is disclosed which comprises light detection means, dispersion means for separating light radiation into spectral components and for directing the spectral components toward the light detection means, means for admitting ... | 03/08/1983 |
