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| Number | Title | Issue Date |
| 8168603 | G-quartet oligonucleotides that target hypoxia-inducible factor 1-α (HIF1α) The present invention concerns particular G-quartet oligonucleotides that are employed for the treatment and/or prevention of cancer. In specific cases, the G-quartet oligonucleotides inhibit HIF-1α. ... | 05/01/2012 |
| 8137675 | Bont/a peptides and methodsof predicting and reducing immunoresistance to botulinum toxin therapy The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides. ... | 03/20/2012 |
| 8129353 | Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combin... | 03/06/2012 |
| 8089628 | Pulsed-multiline excitation for color-blind fluorescence detection The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagn... | 01/03/2012 |
| 8084753 | Method and system for non-contact fluorescence optical tomography with patterned illumination A method and system for non-contact fluorescent optical tomography using patterned illumination is disclosed. The method comprises illuminating a surface of a medium with light from at least one excitation light source to project at least two patterns. Each pattern ... | 12/27/2011 |
| 8062691 | Method for treating medical devices using glycerol and an antimicrobial agent A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination... | 11/22/2011 |
| 8057415 | Trauma cervical stability device and methods of using same for diagnostic purposes Trauma cervical stability devices for use by ambulatory personnel arriving at the scene of an injured patient are disclosed. The trauma cervical stability devices comprise a cap element, releasable and adjustable head straps, a shoulder harness, and at least one adj... | 11/15/2011 |
| 7972801 | Determining and reducing immunoresistance to a toxin therapy using toxin B peptides The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunor... | 07/05/2011 |
| 7968304 | Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin B peptides The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunor... | 06/28/2011 |
| 7931679 | Bone compression device The invention relates to bone compression devices and bone compression systems, and in particular, to bone compression devices and systems for use in connection with vertebrae. The bone compression devices and bone compression systems are disposed, or installed, alo... | 04/26/2011 |
| 7848888 | Method for identification of biologically active agents The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, cr... | 12/07/2010 |
| 7847146 | Model for neurodegenerative disorders The present invention discloses a double transgenic fly that expresses both Tau protein and the human Aβ42 peptide of human amyloid-β precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared ... | 12/07/2010 |
| 7879793 | Treatment of medical condition with A2 domain of von willebrand factor The present invention is directed to methods for the prevention, treatment and/or diagnosis of a medical condition, such as sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for example. In particular, the method employs part or all of the A2 domai... | 02/01/2011 |
| 7875260 | Imaging agents for functional imaging of lymphatic structures Novel imaging agents targeted to a lymph vascular cell receptor and a hyaluranon cell receptor are disclosed. The disclosed imaging agents incorporate biological molecules such as hyaluronic acid which bind to the receptors. Lymph vascular cell receptor expression m... | 01/25/2011 |
| 7868159 | Modulation of negative immune regulators and applications for immunotherapy The invention includes compositions and methods for enhancing immunopotency of an immune cell by way of inhibiting a negative immune regulator in the cell. The present invention provides vaccines and therapies in which antigen presentation is enhanced through inhibi... | 01/11/2011 |
| 7868158 | Modulation of cytokine signaling regulators and applications for immunotherapy The present invention relates to regulation of antigen presentation by cytokine signaling regulators in antigen presenting cells, such as dendritic cells. The invention provides methods of modulating antigen presentation through modulation of cytokine signaling regu... | 01/11/2011 |
| 7855268 | Tolerogizing compositions comprising botulinum toxin type B peptides The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunor... | 12/21/2010 |
| 7829333 | Modulation of hedgehog-mediated signaling pathway The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provi... | 11/09/2010 |
| 7824685 | RTVP based compositions and methods for the treatment of prostate cancer This invention relates to a gene encoding RTVP that has been shown to be up-regulated by p53 using differential display-PCR and subsequently by co-transfection studies. RTVP-1 mRNA is abundant in normal mouse and human prostatic epithelial cells and primary tumors, ... | 11/02/2010 |
| 7811820 | Smooth muscle cell differentiation with CRP, SRF and GATA factors The present invention is directed to generating a smooth muscle cell from another cell, such as a fibroblast, by delivering to the cell serum response factor, a CRP, and a GATA. In specific embodiments, the methods are utilized to generate vascular tissue and/or to ... | 10/12/2010 |
| 7790183 | Combination of antimicrobial agents and bacterial interference to coat medical devices This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and n... | 09/07/2010 |
| 7744893 | T cell receptor CDR3 sequences associated with multiple sclerosis and compositions comprising same The present invention relates generally to the field of treating and monitoring multiple sclerosis by utilizing T-cell receptors peptides. In particular, nucleic acids and peptide sequences of T-cell receptors found in a population of MS patients are provided, along... | 06/29/2010 |
| 7723475 | RTVP-GliPR-like compositions and methods for the detection, treatment and prevention of prostate cancer The invention is directed to purified and isolated novel RGL2 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived... | 05/25/2010 |
| 7695713 | Isolation and identification of T cells The present invention relates to improved autologous T cell vaccines and improved methods for their production. The invention is also directed to methods for treating autoimmune diseases such as multiple sclerosis or rheumatoid arthritis using autologous T cell vacc... | 04/13/2010 |
| 7691587 | Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin B peptides The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunor... | 04/06/2010 |
| 7686758 | Cannula tip for a cardiac assist device The present invention provides an inflow cannula tip that is shaped to prevent suction with the ventricular wall and adapted to prevent platelet adhesion. In particular, the inlet portion of the cannula tip comprises two projections extending from the cylindrical bo... | 03/30/2010 |
| 7670788 | Determining and reducing immunoresistance to a Botulinum toxin therapy using Botulinum toxin B peptides The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunor... | 03/02/2010 |
| 7666412 | Methods for the treatment of neoplastic disorders with anti-caveolin agents The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metast... | 02/23/2010 |
| 7645452 | RTVP based compositions and methods for the treatment of prostate cancer This invention relates to a gene encoding RTVP that has been shown to be up-regulated by p53 using differential display-PCR and subsequently by co-transfection studies. RTVP-1 mRNA is abundant in normal mouse and human prostatic epithelial cells and primary tumors, ... | 01/12/2010 |
| 7635484 | BoNT/A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides. ... | 12/22/2009 |
| 7622252 | Generation of minicircle DNA with physiological supercoiling Methods for the production of supercoiled DNA minicircles and their use as substrates are described herein. ... | 11/24/2009 |
| 7601806 | RTVP-GliPR-like compositions and methods for the detection, treatment and prevention of prostate cancer The invention is directed to purified and isolated novel RGL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived ... | 10/13/2009 |
| 7582478 | Cleaved serum response factor in cardiac diagnosis and therapy The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising elevated cleavage of serum response factor. In further specific embodiment... | 09/01/2009 |
| 7579326 | Gene switch systems employing regulators with decreased dimerization Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer. ... | 08/25/2009 |
| RE40789 | Mammalian checkpoint proteins polypeptides and encoding sequences thereof The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The expressed proteins are used to generate specific antibodies and to inh... | 06/23/2009 |
| 6824972 | Diagnosis and treatment of medical conditions associated with defective NFkappa B(NF-κB) activation Incontinentia Pigmenti (IP) is a neurocutaneous genodermatosis that segregates as an X-linked dominant disorder with a high probability of prenatal male lethality. A locus in Xq28 containing NF-κB Essential Modulator, a gene product involved in the activation of NF... | 11/30/2004 |
| 7537899 | Defects in periaxin associated with myelinopathies The present invention relates to defects in periaxin (PRX) associated with myelinopathies, including Charcot-Marie-Tooth syndrome and/or Dejerine-Sottas syndrome. Unrelated individuals having a myelinopathy from Dejerine-Sottas syndrome have recessive PRX mutations.... | 05/26/2009 |
| 7491549 | Apparatus for desorption and ionization of analytes This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the f... | 02/17/2009 |
| 7470673 | Composition and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis and abnormal cell proliferation Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation is also disclosed having at least one atonal-associated nucleic acid s... | 12/30/2008 |
| 7462699 | BoNT/A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides. ... | 12/09/2008 |
