The ice cream cone was invented at the St. Louis Worlds Fair by Ernest Hamwi in 1904. His waffle booth was next to an ice cream vendor who ran short of dishes. Hamwi rolled a waffle to hold ice cream and the cone was born.
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| Number | Title | Issue Date |
| D657550 | Portion of a display screen for a pill dispenser | 04/17/2012 |
| D657549 | Portion of a display screen for a pill dispenser | 04/17/2012 |
| D657548 | Portion of a display screen for a pill dispenser | 04/17/2012 |
| D657131 | Portion of a display screen for a pill dispenser | 04/10/2012 |
| D657130 | Portion of a display screen for a pill dispenser | 04/10/2012 |
| D657129 | Portion of a display screen for a pill dispenser | 04/10/2012 |
| D657128 | Portion of a display screen for a pill dispenser | 04/10/2012 |
| D657127 | Portion of a display screen for a pill dispenser | 04/10/2012 |
| D657126 | Portion of a display screen for a pill dispenser | 04/10/2012 |
| 8053426 | Progesterone receptor antagonists The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group. ... | 11/08/2011 |
| D644833 | Pill dispenser | 09/13/2011 |
| 8008325 | Plasma carboxypeptidase B inhibitors Compounds of the following formula (I), for example: wherein R1, R2, R3, and R4 are described herein, are useful as inhibitors of plasma carboxypeptidase B. Pharmaceutical composi... | 08/30/2011 |
| 8003787 | Sulphoximine-substituted quinoline and quinazoline derivatives as kinase inhibitors The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compou... | 08/23/2011 |
| 8003655 | Substituted sulphoximines as TIE2 inhibitors and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same The invention relates to substituted sulphoximines according to the general formula (I): in which A, E, G, X, R1, R2, R3, R4, R5, R6, R7, R8 | 08/23/2011 |
| 7999108 | Benzyl amines, a process for their production and their use as anti-inflammatory agents The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents. ... | 08/16/2011 |
| 7987986 | Device and use for storage and provision of medicament wafers To monitor the intake of medicaments present in wafer form, a device is made available which is suitable for storage and provision of such forms of administration. This device comprises medicament pouches, which are arranged as a stack of pouches and contain medicam... | 08/02/2011 |
| 7977325 | 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents This invention relates to compounds of general formula I in which R1 and R2 are described in this application, the use of the compounds of general formula I as inhibitors of protein tyrosine kinases fo... | 07/12/2011 |
| 7973166 | N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula I is described, as well as the process for the production of said compound, and its use as a medi... | 07/05/2011 |
| 7951790 | Progesterone receptor antagonists The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group. ... | 05/31/2011 |
| 7943629 | Sulphimides as protein kinase inhibitors The invention relates to sulphimides as protein kinase inhibitors of the general formula I ... | 05/17/2011 |
| 7935827 | Optically active, heteroaromatic β-hydroxy esters and processes for their preparation from β-keto esters and processes for the preparation of these β-keto esters The present invention relates to new optically active heteroaromatic β-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production. ... | 05/03/2011 |
| 7910573 | Crystalline forms of 11β-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17α-pregna-4,9-dien-3-one The present invention relates to crystalline forms of 11β-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17α-pregna-4,9-dien-3-one. The invention relates in particular to two crystalline ansolvate/anhydrate forms of this compound, polymorphs I and I... | 03/22/2011 |
| 7906533 | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors The invention relates to novel nicotinamide pyridinureas as VEGF receptor kinase inhibitors, their production and use as pharmaceutical agents for preventing or treating diseases that are triggered by persistent angiogenesis. ... | 03/15/2011 |
| 7902229 | Anthranilamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors The invention relates to novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors, their production and use as pharmaceutical agents for preventing or treating diseases that are triggered by persistent angiogenesis. ... | 03/08/2011 |
| 7902178 | Progesterone receptor antagonists The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group. ... | 03/08/2011 |
| 7897626 | 2-substituted thiazole-4-carboxamide derivatives, their preparation and use as pharmaceuticals The present invention relates to 2-substituted thiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof ... | 03/01/2011 |
| 7880042 | Tetrahydronaphthalene derivatives, methods for the production thereof, and the use thereof as antiphlogistics The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (Ia) to processes for preparing them and to their use as antiinflammatory agents. ... | 02/01/2011 |
| 7846928 | Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same The invention relates to substituted pyrazolopyridines according to the general formula (I): in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as defined... | 12/07/2010 |
| 7846917 | 18-Methyl-19-norandrost-4-ene 17, 17-spiro ether (18-methyl-19-nor-20-spirox-4-en-3-one), and pharmaceutical products comprising the same The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group ═NOR or ═NNHSO2R, whe... | 12/07/2010 |
| 7879853 | 4,6-disubstituted pyrimidines and their use as protein kinase inhibitors The invention relates to novel pyrimidine derivatives of Formula (1) which are efficacious inhibitors of protein kinases, in particular of one or more isoforms of the protein kinase B/Akt. ... | 02/01/2011 |
| 7879357 | Pharmaceutical composition in the form of a hydrogel for transdermal administration of active ingredients The invention relates to a pharmaceutical composition in the form of a hydrogel that comprises a carboxylic acid diester, a C2-C4 alkyl alcohol, an active ingredient and a polymer matrix. The invention also relates to the use of a carboxylic ac... | 02/01/2011 |
| 7879314 | Optical imaging of rheumatoid arthritis The present invention concerns the use of indocarbocyanine dyes, in particular indotricarbocyanine dyes for the diagnosis of inflammatory diseases, in particular rheumatoid arthritis, methods of diagnosing inflammatory diseases and an apparatus useful to carry out t... | 02/01/2011 |
| 7871994 | Hormone replacement therapy method and its administration form Method for hormone replacement therapy, in which at least in the established postmenopause a daily unit with at least one hormonal component, namely with at least estrogen (E) and/or at least one gestagen (G) is administered permanently and continuously every day, c... | 01/18/2011 |
| 7863283 | Sulphoximine-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases. ... | 01/04/2011 |
| 7850948 | Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with re... | 12/14/2010 |
| 7842809 | Pyrazolopyridines and salts thereof, a pharmaceutical composition comprising said compounds, a method of preparing same and use of same The invention relates to pyrazolopyridines according to the general formula (I): and salts thereof, to pharmaceutical compositions comprising said pyrazolopyridines and to a method of preparing said pyrazolopyridines as wel... | 11/30/2010 |
| 7825128 | Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs. ... | 11/02/2010 |
| 7825114 | Substituted aminopyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same The invention relates to substituted aminopyrazolopyridines according to the general formula (I): in which A, B, D, E, Ra, R1, R2, R3, R4, R5 and q are as de... | 11/02/2010 |
| 7820664 | Inhibitors of MEK This invention concerns to N-(2-aylamino)aryl sulfonamides, which are inhibitors of MEK, methods of using such compounds in the treatment of hyperproliferative diseases, and to pharmaceutical compositions containing such compounds. ... | 10/26/2010 |
| 7806861 | Closure piece for medical syringe A closure piece (1) for a medical syringe is provided, the syringe having a syringe barrel (3) and a syringe neck (23). The closure piece has an adapter (6) which can be fitted onto the syringe neck (23). A screw-type closure piece... | 10/05/2010 |