Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 7803956 | Benzofuran derivatives useful for treating hyper-proliferative disorders The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders. ... | 09/28/2010 |
| 7714004 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic d... | 05/11/2010 |
| 7632825 | Methods of decreasing or preventing pain using spicamycin derivatives Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided. ... | 12/15/2009 |
| 7592361 | Indole acetic acid derivatives and their use as pharmaceutical agents This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in ... | 09/22/2009 |
| 7585888 | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders. ... | 09/08/2009 |
| 7582646 | Pyrimidine derivatives for treatment of hyperproliferative disorders Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a lin... | 09/01/2009 |
| 7582645 | Pyrimidine derivatives for treatment of hyperproliferative disorders Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharm... | 09/01/2009 |
| 7563791 | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angio... | 07/21/2009 |
| 7528255 | Hydroxy, ω-carboxyaryl substituted diphenyl ureas and dirivatives thereof as raf kinase inhibitors The invention relates to the use of a group of aryl ureas in treating raf mediated diseases and pharmaceutical compositions for use in such therapy of the formula wherein, Y is NHR | 05/05/2009 |
| 7517880 | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy. ... | 04/14/2009 |
| 7511048 | Pyrimidothienoindazoles The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative d... | 03/31/2009 |
| 7511041 | Fused azole-pyrimidine derivatives The present invention relates to hovel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3... | 03/31/2009 |
| 7494978 | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... | 02/24/2009 |
| 7488716 | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... | 02/10/2009 |
| 7488715 | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... | 02/10/2009 |
| 7488714 | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... | 02/10/2009 |
| 7476742 | Indane acetic acid derivatives and their use as pharmaceutical agents This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases and to pharmaceutical compositions containing these compounds. ... | 01/13/2009 |
| 7462696 | Human antibodies that have MN binding and cell adhesion-neutralizing activity The invention is composed of monoclonal human MN antibodies or MN antibody fragments that target the GEEDLP (SEQ ID NO: 118) repeat within the proteoglycan domain. The proteoglycan domain of the MN cell surface protein contains four of these identical GEEDLP (SEQ ID... | 12/09/2008 |
| 7429584 | Furo[2.3-b]pyridine derivatives for the treatment of hyper-proliferative disorders This invention relates to a compound of Formula (I) wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy halo, OH, CF3, CN, NO | 09/30/2008 |
| 7423156 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ... | 09/09/2008 |
| 7420066 | Benzofuran derivatives useful for treating hyper-proliferative disorders The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders. ... | 09/02/2008 |
| 7371763 | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy. ... | 05/13/2008 |
| 7358386 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic d... | 04/15/2008 |
| 7351834 | ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. ... | 04/01/2008 |
| 7351735 | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders ... | 04/01/2008 |
| 7329670 | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or heteroaryl moiety. The compounds inhibit raf kinase and are useful in the tre... | 02/12/2008 |
| 7265144 | Anilinopyrazole derivatives useful for the treatment of diabetes The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders. ... | 09/04/2007 |
| 7238701 | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders The present invention relates to a compound of Formula (I) and its use in treating lung and breast cancer. ... | 07/03/2007 |
| 7235576 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. ... | 06/26/2007 |
| 7144885 | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders ... | 12/05/2006 |
| 7132395 | Antiviral methods using human rhinovirus receptor (ICAM-1) Method of inhibiting human rhinovirus (HRV) Infection by contacting said HRV with a polypeptide comprising a fragment of human rhinovirus major receptor (HRR), said fragment comprising the HRV binding site and being selected from a specific group consisting of HRR d... | 11/07/2006 |
| 7112597 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic d... | 09/26/2006 |
| 7109196 | 1,8 Naphthyridine derivatives and their use to treat diabetes and related disorders The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the inventio... | 09/19/2006 |
| 7098207 | Imidazotriazinones and the use thereof Novel imidazotriazinones of general formula a method for the production and the pharmaceutical use thereof are disclosed. ... | 08/29/2006 |
| 7091228 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ... | 08/15/2006 |
| 7071207 | Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds... | 07/04/2006 |
| 7041646 | Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders. ... | 05/09/2006 |
| 6994956 | Method for assaying enzyme activity The present invention relates to methods for assessing enzyme activity utilizing a phase partition system. In addition, the present invention also relates to methods for screening and identifying compounds that may be used, for example, for the treatment of diabetes... | 02/07/2006 |
| 6972319 | Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use This invention provides novel peptides that function in vivo to stimulate insulin release from pancreatic beta cells in a glucose-dependent fashion. These insulin secretagogue peptides are shown to stimulate insulin release in rat islet cells in vitro, and in vivo. ... | 12/06/2005 |
| 6964971 | 1,6-naphthyridine derivatives and their use to treat diabetes and related disorders The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention rela... | 11/15/2005 |
