Assignee: Barnes-Jewish Hospital

Location: St. Louis, MO
No. of patents: 23

Number	Title	Issue Date
8003078	Targeted MR imaging agents MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of targe...	08/23/2011
7964360	Uncoupled collagen synthesis and degradation assays The invention relates to methods for determining the progression of cartilage degeneration diseases, such as osteoarthritis and rheumatoid arthritis, by quantitating collagen synthesis and degradation markers in patient samples. One can determine whether a cartilage...	06/21/2011
7803374	Targeted atherosclerosis treatment This invention relates generally to methods for ameliorating at least one symptom or aspect of atherosclerosis. The methods include administration of targeted carrier compositions comprising a therapeutic agent effective in ameliorating at least one aspect of athero...	09/28/2010
7727512	Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ...	06/01/2010
7566442	Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ...	07/28/2009
7344698	Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ...	03/18/2008
7279150	Chelating agents with lipophilic carriers Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. ...	10/09/2007
7255875	Integrin targeted imaging agents Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific ...	08/14/2007
7235227	Paramagnetic particles that provide improved relaxivity An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as...	06/26/2007
7220401	Blood clot-targeted nanoparticles Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further incl...	05/22/2007
7186399	Methods for targeted drug delivery A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c)...	03/06/2007
7179449	Enhanced ultrasound detection with temperature-dependent contrast agents Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are disclosed. The methods and devices can be used for enhanced imaging alone or...	02/20/2007
7096057	Method and apparatus for intracorporeal medical imaging using a self-tuned coil Disclosed herein is an RF probe for use with a medical imaging apparatus, the probe comprising an intracorporeal self-tuned resonator coil for receiving a signal indicative of an image of an interior portion of a body. The resonator coil is preferably coupled to a t...	08/22/2006
7087227	Cartilage composites and methods of use Disclosed are neocartilage compositions characterized by having multiple layers of cells, said cells being surrounded by a substantially continuous insoluble glycosaminoglycan and collagen-enriched hyaline extra-cellular matrix, and which neocartilage phospholipids ...	08/08/2006
7056692	Modulation of pleiotrophin signaling by receptor-type protein tyrosine phosphatase beta/zeta The mechanism by which pleiotrophin binds to the receptor protein tyrosine phosphatase β/ζ(RPTP β/ζ) is disclosed along with methods of modulating both pleiotrophin expression and signaling to treat, prevent and inhibit abnormal cell growth states. Specifically ...	06/06/2006
6913586	Method and apparatus for determining a dorsiflexion angle Apparatus for determining a dorsiflexion angle of a surgical patient's foot relative to the corresponding leg during tendon surgery. The apparatus includes a leg member having a first support adapted for engaging at least one of a lateral malleolus and a medial mall...	07/05/2005
6869591	Paramagnetic particles that provide improved relaxivity An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as...	03/22/2005
6821506	Site specific binding system, imaging compositions and methods A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c)...	11/23/2004
6757423	Methods of processing tagged MRI data indicative of tissue motion including 4-D LV tissue tracking A method for tracking motion of tissue in three or four dimensions by obtaining a model from imaging data having tag planes from which a grid of control points may be defined. First, knot planes are calculated from the grid of control points of the imaging data. Nex...	06/29/2004
6720152	Diagnosis of histoplasmosis using antigens specific for H. capsulatum A method for identifying a protein antigen to a target fungus is disclosed. The method comprises screening expressed proteins from a cDNA gene expression library with antisera to the target fungus and cross-screening with antisera to a nontarget fungus. Antibodies t...	04/13/2004
6713249	Cell matrix plaques of initial bone formation An isolated and essentially purified cell matrix plaque of initial bone formation comprising of αvβ3 integrin and rapid assays using such cell matrix plaques to measure potentials of factors, regimens or tissues for stimulation and/or inhibit...	03/30/2004
5989520	Site specific binding system, imaging compositions and methods A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating age...	11/23/1999
5987348	ECG triggered MR imaging method and apparatus A method of imaging a portion of a body placed in a static magnetic field by means of magnetic resonance (MR) includes the measurement of ECG data of the body in the form of a vector cardiogram, and determination of an acquisition period from the ECG data...	11/16/1999

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Assignee: Barnes-Jewish Hospital