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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7960394 | Quinazoline derivative This invention provides a compound or its pharmaceutically-acceptable salt of formula (I) wherein R1 represents a lower alkyl group et al; R2 and R3 are same and different and represents hyd... | 06/14/2011 |
| 7915263 | Aminopyridine derivatives having aurora A selective inhibitory action The present invention relates to a compound of formula I: wherein: R1 is a hydrogen atom, F, CN, etc.; R1′ is a hydrogen atom or lower alkyl which may be substituted; R2 is O, S, SO, SO... | 03/29/2011 |
| 7902376 | Process for preparing chiral dipeptidyl peptidase-IV inhibitor intermediates A novel process is provided for the preparation of chiral trans-2,3-disubstituted 5-oxotetrahydropyrans of structural formula (I): wherein Ar is optionally substituted phenyl and P is a primary amine protecting group. These... | 03/08/2011 |
| 7902369 | Diaryl-substituted five-membered heterocycle derivative The present invention provides the compounds represented by formula (I): (I) or pharmaceutical salts thereof, wherein: X1 represents oxygen atoms and the like, X2 | 03/08/2011 |
| 7875633 | Phenylpyridone derivative A compound represented by the formula (I) is contained as an active ingredient: wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like, or R1 together wit... | 01/25/2011 |
| 7803807 | Benzimidazole derivatives The present invention relates to compounds of Formula (I) wherein A, B and C are independently methine, said methine being optionally substituted; D is nitrogen; T, U, V and W are independently methine or nitrogen, said met... | 09/28/2010 |
| 7799820 | 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof. In the formula,... | 09/21/2010 |
| 7767881 | Utilization of histamine receptor h3 gene participating in body weight or food intake control To clarify histamine receptor H3 protein function in vivo, the present inventors constructed a nonhuman higher animal in which the expression of a histamine receptor H3 gene was artificially inhibited. As a result, the present inventors found that this nonhuman high... | 08/03/2010 |
| 7754743 | Heteroarylcarbamoylbenzene derivatives Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): [wherein X1 represents oxygen, etc., X2 represents oxyge... | 07/13/2010 |
| 7732456 | Pyridone derivative The invention provides pyridone derivatives represented by a general formula (I) [in the formula, R1 and R2 may be same or different and stands for H, etc., or R1 an... | 06/08/2010 |
| 7728025 | 2-heteroaryl-substituted benzimidazole derivative A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity ... | 06/01/2010 |
| 7727998 | Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient The invention provides melanin-concentrating hormone receptor antagonists containing as the active ingredient piperidine derivatives represented by the general formula [I]: [wherein R1 is... | 06/01/2010 |
| 7723046 | Method of screening for a compound using guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37 The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”. cDNA containing the ORF of the gene was cloned and its nucleotide sequence was de... | 05/25/2010 |
| 7718801 | Substituted imidazole derivative The present invention relates to a compound represented by Formula [I] or a pharmaceutically acceptable salt or ester thereof: wherein: X1, X2, X3, and X | 05/18/2010 |
| 7709475 | Selective inhibitors against Cdk4 and Cdk6 having aminothiazole skeleton The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2; Y1, Y2, Y3, Y4 | 05/04/2010 |
| 7696339 | Nucleic acid encoding monkey QRFP There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound... | 04/13/2010 |
| 7691860 | Sulfonamide derivatives The present invention relates to compounds of the general formula (I): wherein A, B, C and D each independently are a methine group or a nitrogen atom, said methine group optionally having a substit... | 04/06/2010 |
| 7687502 | Substituted quinazoline or pyridopyrimidine derivative The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is nitrogen atom, etc.; Y is oxyge... | 03/30/2010 |
| 7683218 | Method for producing thioether compound Disclosed is an efficient and widely-applicable method for commercially producing a thioether compound or a thiol compound which is useful as a pharmaceutical compound or a production intermediate of it. Specifically disclosed is a method for producing a thioether c... | 03/23/2010 |
| 7629362 | 2-pyridine carboxamide derivatives The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitro... | 12/08/2009 |
| 7595316 | Heteroaryloxy nitrogenous saturated heterocyclic derivative Compound of the formula: (I) [wherein each of X1, X2 and X3 independently represents N or CH, W represents the formula (II):(II) or the formula (III):(III) and Y represents a group of the formula (IV):(IV)], or a pharmacologically ac... | 09/29/2009 |
| 7589096 | Azole derivatives The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine ... | 09/15/2009 |
| 7566781 | Imidazopyridine compound The present invention provides an imidazopyridine compound represented by formula (I), wherein R1 and R2 each independently represent a C1-6 alkyl group et al; R3 and R4 | 07/28/2009 |
| 7557117 | 4-oxoimidazolidine-2-spiropiperidine derivatives The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] [in which A1, A2, A3, A4 and A5 stand for optionally haloge... | 07/07/2009 |
| 7541477 | Antagonists to melanin-concentrating hormone receptor comprising benzimidazole derivative as active ingredient This invention relates to a benzimidazole derivative of the general formula [I] [wherein B1, B2, and B3 represent hydrogen atom or lower alkyl; R1 and R2 are same or di... | 06/02/2009 |
| 7531668 | 2-arylcarboxamide-nitrogenous heterocycle compound A compound represented by the formula [I]: [wherein R1 and R2 are the same or different and each represents C1-6 alkyl, C3-8 cycloalkyl, et al; R3a, R3b, and... | 05/12/2009 |
| 7510833 | Method for examining obesity or leanness In the examination of obesity or leanness, the examination is based on the expression level of the MCP-1 gene or the MCP-1 protein in a tissue or cell analyte, or on the polymorphism in the gene. In the evaluation of compounds, including screening for therapeutic ag... | 03/31/2009 |
| 7504432 | Ester derivatives This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); ... | 03/17/2009 |
| 7491720 | Aminopyridine derivatives having Aurora A selective inhibitory action The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1 | 02/17/2009 |
| 7485647 | 2-aminoquinoline derivatives This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R1 and R2 either stand for lower alkyl, lower cycloalkyl, etc., or R1 | 02/03/2009 |
| 7482358 | Imidazoline compounds Compounds represented by the general formula (I): wherein Ar1 and Ar2 are each aryl or heteroaryl; R1 is lower cycloalkyl, —Ar3, or a group of the general formula (a), (b) or (c... | 01/27/2009 |
| 7452908 | Amide derivatives This invention relates to compounds which are represented by the general formula [I] [in which A stands for a group of the following formula [ao] or [b0] ... | 11/18/2008 |
| 7439535 | Process for exchanging functional groups by halogen-metal exchange reaction A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixt... | 10/21/2008 |
| 7422898 | Nucleic acid encoding monkey Gpr103 There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound... | 09/09/2008 |
| 7398161 | Sampling method and sampling device, and logD measuring method and logD measuring system A sampling method sampling a lower-layer liquid from a liquid body comprised of two layers of liquids, an upper-layer liquid (octanol) and the lower-layer liquid (buffer solution), without mixing the layers. An extracting device is provided with a tubular apical end... | 07/08/2008 |
| 7388010 | Quinoxalinone derivatives A quinoxalinone derivative of the formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein; X is NH, S or the like; Y is O or the like; | 06/17/2008 |
| 7374895 | Guanosine triphosphate (GTP) binding protein-coupled receptor proteins that bind histamine and are expressed in the brain A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA is isolated. Proteins encoded by these cDNAs have an activity of low... | 05/20/2008 |
| 7368569 | Process for making spirolactone compounds This invention relates to a process for making spirolactone compounds analogous to formula I ... | 05/06/2008 |
| 7365079 | Azole derivatives The present invention relates to a compound of the formula (I): wherein Az is a group comprising a monocyclic azole or a bicyclic aromatic ring of the same or different fused azoles; T, U, V and W are independently methine ... | 04/29/2008 |
| 7354946 | Biarylurea derivatives The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a c... | 04/08/2008 |
