Assignee: Aventis Pharmaceuticals Inc.

Location: Bridgewater, NJ
No. of patents: 206

Number	Title	Issue Date
8183231	Substituted propane phosphinic acid derivatives The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds...	05/22/2012
8173682	Substituted pyridones as inhibitors of poly(ADP-ribose) polymerase (PARP) The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates t...	05/08/2012
8053458	Dipyrazole compounds and their use as central nervous system agents The present invention is directed to dipyrazole compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I. The compounds of t...	11/08/2011
8008340	3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase I A method for inhibiting casein kinase Iε activity, comprising administering to said patient a therapeutically effective amount of a compound of formula I. its stereoisomer, enantiomer, racemate, ta...	08/30/2011
7989584	AKT nucleic acids, polypeptides, and uses thereof The present invention relates to human Akt3 proteins and polypeptides. The invention also relates to isolated nucleic acids encoding human Akt3, to vectors containing them and to their therapeutic uses, in particular for gene therapy. Expression of Akt3 inhibits cel...	08/02/2011
7977310	Method for reducing cardiovascular morbidity and mortality in prediabetic patients and patients with type 2 diabetes This invention relates to a method of reducing cardiovascular morbidity and mortality in a prediabetic or Type 2 Diabetes patient population. The method comprises administering an effective dosage of a long acting insulin, preferably insulin glargine, to a prediabet...	07/12/2011
7977045	Aqueous-based pharmaceutical composition An aqueous pharmaceutical composition which is capable of being sprayed into the nasal cavity of an individual and which comprises: (A) a pharmaceutically effective amount of solid particles of medicament which is effective in treating a bodily condition by virtue o...	07/12/2011
7972844	Nuclear factor κB inducing factor The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cD...	07/05/2011
7947684	1-aroyl-piperidinyl benzamidines This invention relates to compounds of formula which inhibit Factor Xa or tryptase, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from condi...	05/24/2011
7943616	Azaindoles for inhibiting aurora2 and other kinases The invention is directed to physiologically active compounds of general formula (I):— and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds a...	05/17/2011
7928231	Thienopyrazoles Thienopyrazoles of formula I, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2...	04/19/2011
7923466	3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I Methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase Iε activity comprising the administration of a compounds of formula (I) and formula (II) as inhibitors ...	04/12/2011
7919508	3-piperidinylisochroman-5-ols as dopamine agonists The present invention provides compounds of formula I: a stereoisomer or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, X and n are defined as d...	04/05/2011
7884200	Retroviral vectors for delivery of interfering RNA Provided herein are retroviral vectors for delivering interfering RNA into cells. ...	02/08/2011
7777042	N-sulfonylpipecolic acid derivative FKBP binding composition and pharmaceutical use thereof A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of formula I, wherein, R, R1, ...	08/17/2010
7772252	Heterocyclic substituted carbonyl derivatives and their use as dopamine Dreceptor ligands The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine...	08/10/2010
H2246	Method for analyzing continuous glucose monitoring data A method for predicting the effectiveness of medication-based therapy in lowering average blood glucose levels in a diabetic patient is provided. This method may further comprise selectively recommending a medication-based therapy on the basis of the arithmetic aver...	08/03/2010
7754678	Membrane penetrating peptides and uses thereof The present invention is directed to membrane penetrating peptides useful as in vivo, ex vivo and in vitro intracellular delivery devices for compound of interest. More particularly, the invention involves identification of membrane penetrating peptides which may be...	07/13/2010
7741493	Heterocyclic compounds as P2X7 ion channel blockers The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are ...	06/22/2010
7723074	Nucleic acid molecules encoding prostaglandin receptor proteins Described herein is a novel member of the prostanoid receptor family, a guinea pig prostaglandin D2 receptor. Described are the receptor, the nucleic acid that encodes it, and various uses for both. ...	05/25/2010
7687540	Substituted propane phosphinic acid esters The present invention relates to certain esters of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1 and R2 are as defined herein. The compounds of this invention are u...	03/30/2010
7662628	Human Akt3 nucleic acid and uses thereof The present invention relates to human Akt3 proteins and polypeptides. The invention also relates to isolated nucleic acids encoding human Akt3, to vectors containing them and to their therapeutic uses, in particular for gene therapy. Expression of Akt3 inhibits cel...	02/16/2010
7652046	Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase I The present invention comprises methods for the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders through the administration of compounds of formula (I) and formula (II) ...	01/26/2010
7642249	Dihydrogen phosphate salt of a prostaglandin D2 receptor antagonist The present invention is directed to dihydrogen phosphate salt 2-(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-2-methyl-propionic acid of Formula (III), a pharmaceutical composition comprising...	01/05/2010
7638539	1, 3, 4-oxadiazol-2-ones as peroxisome-proliferator activated receptor delta modulators and their use in the treatment of neurological and metabolic disease The present invention is directed to 1,3,4-oxadiazalones, i.e., the compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein...	12/29/2009
7629376	3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I The present invention discloses and claims compounds of formula (I) and formula (II) as inhibitors of human casein kinase Iε, and methods of using the compounds of formula (I) and formula (II) for treating central nervous ...	12/08/2009
7625889	Substituted bis aryl and heteroaryl compounds as selective 5HTantagonists The present invention relates to a series of substituted bis aryl and heteroaryl compounds of formula (I): Wherein X, Y, Z, A, B, D, Ar, R1 and R2 are as defined herein. The compounds of this invention...	12/01/2009
7612195	Retroviral vectors for delivery of interfering RNA Provided herein are retroviral vectors for delivering interfering RNA into cells. ...	11/03/2009
7612075	Substituted oxoazaheterocyclyl compounds This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these comp...	11/03/2009
7579447	Antibodies against LLG polypeptides of the triacylglycerol lipase family Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of sai...	08/25/2009
7576109	1,3,4-oxadiazol-2-ones as PPAR delta modulators and their use thereof The present invention is directed to 1,3,4-oxadiazolones, compounds of formula I and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein.	08/18/2009
7556931	Furosemide modulators of HM74 Host cells expressing HM74 were used to obtain furosemide-like molecules with agonist activity having the following structure formula: ...	07/07/2009
7550469	Heterocyclic amide derivatives and their use as dopamine D3 receptor ligands The invention relates to heterocyclic substituted amide derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D	06/23/2009
7541368	Pyrazoles as inhibitors of tumor necrosis factor The present invention provides compounds of Formula (I) and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates; pharmaceutical compositions comprisin...	06/02/2009
7538233	Coumarins as iNOS inhibitors The present invention relates to coumarins of the formula (I): that are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions and methods of using these compounds as inhibitors of nitric oxide synthase ...	05/26/2009
7538106	Application of 2-cyano-10- (2-methyl-3- (methylamino)- propyl) phenothiazine or a pharmaceutically acceptable salt as medicament The present invention relates to the application of 2-cyano-10-(2-methyl-3-(methylamino)-propyl)phenothiazine or a pharmaceutically acceptable salt thereof to produce a medicament intended for the treatment of sleep disorders, anxiety disorders, mood disorders, mixe...	05/26/2009
7534803	Method of treating demyelinating diseases or conditions N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord...	05/19/2009
7521445	Heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine...	04/21/2009
7488799	Prostaglandin receptor protein Described herein is a novel member of the prostanoid receptor family, a guinea pig prostaglandin D2 receptor. Described are the receptor, the nucleic acid that encodes it, and various uses for both. ...	02/10/2009
7482459	[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase The present invention extends to the compound of formula I: or a prodrug, pharmaceutically acceptable salt, or solvate of said compound. Furthermore, the present invention is directed to a pharmaceutical composition...	01/27/2009

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Assignee: Aventis Pharmaceuticals Inc.