Assignee: Aventis Pharma S.A.

Location: Antony, FR
No. of patents: 221

Number	Title	Issue Date
8173402	Modified yeasts and uses thereof, in particular for producing steroid derivatives The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20αHSD type activ...	05/08/2012
8110571	Benzimidazole and benzothiazole derivatives, method for preparing same, use thereof as drugs, pharmaceutical compositions and novel use especially as c-MET inhibitors This invention relates to benzimidazole and benzothiazole compounds of formula (I) to methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment comprising admini...	02/07/2012
8058290	7-substituted aza-indazoles, compositions containing same, production method and use thereof The disclosure relates to compounds of formula (I): which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer ...	11/15/2011
8008322	Substituted pyrazolopyridines, compositions containing them, method for the production thereof, and their use The disclosure relates to substituted pyrazolo-pyridines, compositions containing them, methods for the production thereof, and to their use as medicaments, in particular, as anticancer agents. ...	08/30/2011
7998667	Mutations of the parkin gene, compositions, methods and uses The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of...	08/16/2011
7994212	Method of treating cancer with docetaxel and doxorubicin Antitumor combinations comprising a taxane and at least one antibiotic for treating neoplastic diseases are described. ...	08/09/2011
7977065	Yeast strains autonomously producing steroids The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains. ...	07/12/2011
7935819	Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors Compounds of formula (I): wherein Ra, Rb, R, X1 and X2 are as defined in the disclosure, pharmaceutical compositions comprising said compounds, processes for making and methods of using the same are pr...	05/03/2011
7884123	Substituted thieno[2,3-c]pyrazoles, process for preparing them, compositions containing them, and use thereof Compounds of formula (I), wherein R1 and R3 have the meanings given in the description, said compounds being in all isomeric forms; and salts thereof; processes for the preparation of the compounds and intermediates; compos...	02/08/2011
7884084	Oligonucleotides which inhibit expression of the OB-RGRP protein The present application relates to antisense oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions. It also relates to a method for detecting compounds which ...	02/08/2011
7879592	Modified yeasts and uses thereof, in particular for producing steroid derivatives The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More particularly, the invention describes strains having a reduced 20αHSD type activ...	02/01/2011
7825115	Cyclic urea compounds, preparation thereof and pharmaceutical use thereof as kinase inhibitors The disclosure relates to a cyclic urea compound of formula I: as defined herein, to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use as an inhibitor on a protein kinase. ...	11/02/2010
7786114	Bis-azaindole derivatives, preparation and pharmaceutical use thereof as kinase inhibitors Compounds of formula (I): wherein R1, R2, R3, R4, and R5 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and the use thereof as protein kinase inhibitors...	08/31/2010
7759379	Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs the...	07/20/2010
7754713	4-benzimidazol-2-ylpyridazin-3-one derivatives Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compound...	07/13/2010
7741316	Pharmacological uses of azetidine derivatives A method of treating or preventing Alzheimer's disease, Parkinson's Disease and/or schizophrenia, this method comprising administering to a patient in need of such treatment a compound of formula: in which R, R3 ...	06/22/2010
7732610	Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medica...	06/08/2010
7700823	Transgenic animals exhibiting major disorders related to Alzheimer's disease The present invention relates to nonhuman transgenic animals exhibiting major disorders related to Alzheimer's disease. The animals can be used for demonstrating compounds intended for the treatment of Alzheimer's disease. ...	04/20/2010
7670829	Yeast strains autonomously producing steroids The present invention relates to genetically modified yeast strains autonomously producing, from a simple carbon source, steroids. The invention also relates to a method for producing steroids from such yeast strains. ...	03/02/2010
7667054	Cytotoxic agents comprising new taxanes The invention relates to novel cytotoxic agents comprising taxanes and their therapeutic use as a result of delivering the taxanes to a specific cell population in a targeted fashion by chemically linking the taxane to a cell binding agent. ...	02/23/2010
7638529	Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medica...	12/29/2009
7632952	Benzothiazoles and the use thereof as medicaments The invention especially relates to novel chemical compounds, especially novel benzothiazole derivatives, to compositions containing said compounds, and to the use thereof as medicaments. ...	12/15/2009
7618818	Method for detecting leptin receptor ligands The present invention relates to a method for detecting leptin receptor ligands by measuring the energy transfer between fusion proteins comprising a leptin receptor and an energy donor protein or an energy acceptor acceptor protein proteins. The present invention a...	11/17/2009
RE40940	Yeast promoter and use thereof The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity. to expression vectors comprising these sequences and to their use for the production of proteins. ...	10/20/2009
7595320	Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, process for preparing them, compositions containing them and use thereof The present invention concerns hydrazinocarbonyl-thieno[2,3-c]pyrazoles of formula (I): wherein R1, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions containing the same and thei...	09/29/2009
7592365	Substituted pyrroles, compositions containing same, method for making same and use thereof The disclosure concerns substituted pyrroles of formula (I): wherein A, L, Ar, R1, R2, R5, and Ra are as defined in the disclosure, compositions containing the same, methods for making the same and uses thereof, in particul...	09/22/2009
7575930	Method for analyzing oligosaccharides from blood plasma The present invention relates to a method for analyzing oligosaccharides constituting the heparins of low molecular weight and the heparins of very low molecular weight from blood plasma. ...	08/18/2009
7566736	Substituted indoles, compositions containing them, method for the production thereof and their use Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal pr...	07/28/2009
7560571	Substituted pyrroles and imidazoles, compositions containing same, manufacturing process therefor and use thereof The disclosure concerns substituted imidazoles and pyrroles, compositions containing the same, the preparation thereof, and the use thereof as medicaments, particularly as anti-cancer agents. ...	07/14/2009
7528147	Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use t...	05/05/2009
7524838	Pyrazolyl derivatives, preparation process and intermediates of this process as medicinal products and pharmaceutical compositions containing them The present invention relates to the novel derivatives of formula (I) in which A is, if it is present, a (C1-C6) alkyl, a (C3-C6) alkenyl, a (C3-C6) alkynyl, a (C3-C7) cycloalkyl or a (C5-C7) cycloalkenyl, R1 is an NR6R7, (C4...	04/28/2009
7517902	Substituted indazoles, compositions containing the same, and the preparation and use thereof Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds. ...	04/14/2009
7517881	Triazine derivatives, their preparation and therapeutic application thereof The invention relates to triazine derivatives of general formula (I): Wherein R1, R2 and R3 are as defined herein. The invention also relates to a method for preparing these triazine derivat...	04/14/2009
7507734	Pyridazinone derivatives Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these com...	03/24/2009
7491710	Organophosphorus derivatives of indazoles and use thereof as medicinal products The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers. ...	02/17/2009
7482352	Chemical derivatives and their application as antitelomerase agents The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans. ...	01/27/2009
7476670	Purine derivatives, method for preparing, pharmaceutical compositions and novel use The invention relates to novel products of formula (I): in which: Y represents N, O, S, CHR3 or ═CR3 the dashed line representing a single or double bond, R and R1 represent in particular H, Hal,...	01/13/2009
7473701	Substituted indazoles, compositions containing them, method of production and use Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particular in oncology. ...	01/06/2009
7470689	4-benzimidazol-2-ylpyridazin-3-one derivatives Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compound...	12/30/2008
7435820	Substituted tetrahydro-1-pyrazolo [3,4-]pyridines compositions comprising them, and use Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology...	10/14/2008

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Assignee: Aventis Pharma S.A.