Assignee: Aventis Pharma Deutschland GmbH

Location: Frankfurt, DE
No. of patents: 60

Number	Title	Issue Date
7662383	Chimeric antibody against tumor associated antigens and its use in diagnosing tumors The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put t...	02/16/2010
7300950	Pyrazole derivatives, their preparation and their use in pharmaceuticals The present invention relates to pyrazole derivatives of the formula I, their preparation and their use in pharmaceuticals: in which X, R1, R1a, R2, R3, R4 a...	11/27/2007
7166572	Cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical A cyclohexapeptide compound of general formula (I), wherein R1 is C1–C20 alkyl; C9–C20 alkenyl; C9–C20 alkoxyphenyl; an aryl group selected from: phenyl, biphenyl, terphenyl and napht...	01/23/2007
6987177	Modified oligonucleotides, their preparation and their use Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as ai...	01/17/2006
6982353	C2-disubstituted indan-1-ol compounds, their derivatives, processes for their preparation, and their use as pharmaceuticals The present invention is directed to C2-disubstituted indan-1-ol systems of the Formula I, physiologically acceptable salts and physiologically functional derivatives thereof, and pharmaceutical compositions comprising...	01/03/2006
6949556	Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents The present invention relates to compounds of general formula (I), wherein R1-R4 have the meanings given in the specification, A is CH2, CHOH or CH—(C1-C3-alkyl), B and C a...	09/27/2005
6930103	Use of vasopeptidase inhibitors in the treatment of metabolic diseases, nephropathy and advanced glycation end-product associated diseases The invention describes and claims the use of vasopeptidase inhibitors of formula (I) for the treatment of nephropathy in diabetic or non-diabetic patients, including diabetic or non-diabetic nephropathy, glomeruloneph...	08/16/2005
6927236	Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals The present invention relates to compounds of the formula which are formed during fermentation by the microorganism Coniochaeta ellipsoidea Udagawa, DSM 13856, or by one of its mutations and/or variants, and che...	08/09/2005
6926896	Monoclonal antibodies (MAbs) against tumor-associated antigens, the preparation and use thereof The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put t...	08/09/2005
6919441	Polyamide-oligonucleotide derivatives, their preparation and use The invention provides polyamide-oligonucleotide derivatives of the formula: F[(DNA-Li)q(PNA-Li)r(DNA-Li)s(PNA)t]xF′. In the formula, q, r, s, and t are, independently of one another, zero ...	07/19/2005
6919380	Derivatives of C2-substituted indan-1-ol systems for the prophylaxis or treatment of obesity Derivatives of C2-substituted indan-1-ol compounds of formula I: its physiologically acceptable salts, and its physiologically functional derivatives for the prophylaxis or treatment of obesity are disclosed herein. Co...	07/19/2005
6913898	Luminescent method of detecting soluble guanylate cyclase The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least ...	07/05/2005
6911453	Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them The invention relates to compounds of the formula I in which R1 to R9 are as defined herein. In one embodiment, these compounds may be used as antihypertensives, for reducing or preventing ischemia-induced damage, as m...	06/28/2005
6908897	Covalently bridged insulin dimers Provided herein is a heretofore unknown insulin analogue, a pharmaceutical composition comprising such an insulin analogue, as well as processes for preparing such an insulin analogue and such a pharmaceutical composition. ...	06/21/2005
6906084	Indole derivatives as factor Xa inhibitors The present invention relates to compounds of formula I, in which R0; R1; R2; R3; R4; R5; R6; R7; Q; V, G and M have the meanings ...	06/14/2005
6905820	Polyamide nucleic acid derivatives, and agents and processes for preparing them The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinki...	06/14/2005
6821990	Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one An ethanol solvate form of (−)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-methyl)piperidinyl]-4H-1-benzopyran-4-one hydrochloride (Form II), a method of making Form II and a composition comprising Form II. ...	11/23/2004
6812256	Polysubstituted indan-1-ol systems for the prophylaxis or treatment of obesity Polysubstituted indan-1-ol compounds of formula I, its physiologically acceptable salts and physiologically functional derivatives are disclosed Compositions comprising the same, methods of preparation and methods for ...	11/02/2004
6812250	Carboxamide-substituted phenylurea derivatives, process for their preparation and their use as medicaments The invention relates to carboxamide-substituted phenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I in which the radicals have...	11/02/2004
6812257	Polysubstituted indan-1-ol systems for the prophylaxis or treatment of obesity Polysubstituted indan-1-ol compounds of formula I, its physiologically acceptable salts and physiologically functional derivatives are disclosed Compositions comprising the same, methods of preparation and methods for ...	11/02/2004
6809177	Process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues The invention relates to a process for the conversion of echinocandin class of peptides to their C4-homotyrosine monodeoxy analogues, particularly mulundocandin to deoxymulundocandin, which consists of a single step selective reduction of C4-htyr (homotyrosine) hydr...	10/26/2004
6794408	Drechsleranol derivatives, processes for their preparation and their use The present invention provides novel drechsleranol compounds of formula (I) which are formed by the microorganism Drechslera australlensis, ST 003360, DSM 14093, or a fungus ST 004112, DSM 14524, during fermentation. A process for their preparation, pharmaceu...	09/21/2004
6794517	Bis(trifluoromethyl)hydantoins as intermediates for pharmaceutically active ingredients The present invention relates to hydantoins of formula I, in which R is the residue of an amino carboxylic acid or of an amino carboxylic acid derivative, which is obtained formally by removing an NH2 group fr...	09/21/2004
6777544	Polyamide nucleic acid derivatives and agents and processes for preparing them The present invention relates to PNA derivatives which carry, at the N terminus of the PNA backbone, a phosphoryl radical. The phosphoryl radical can be, for example, a phosphate radical, or a substituted phosphoryl radical, with substituted phosphoryl derivatives c...	08/17/2004
6762326	C2-substituted idan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals Embodiments of the invention relate to C2-substituted indan-1-ones and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention include compounds of formula I	07/13/2004
6759412	Acylated 6,7,8,9-tetrahydro-5H-benzocycloheptenyl amines and their use as pharmaceutical agents The present invention relates to compounds according to the general formula (I), wherein R1-R4 have the meanings given in the description, A is CH2, CHOH or CH—(C1-C3	07/06/2004
6716411	Method for finding nucleotide synthesis inhibitors having fewer side effects The invention relates to a method for finding nucleotide synthesis inhibitors which have a better therapeutic window. An efficacious dose of a nucleotide synthesis inhibitor is administered to a mammal. The concentration of the nucleotide synthesis inhibitor in the ...	04/06/2004
6717008	Derivatives of C2-substituted indan-1-ol compounds, methods for their preparation and use Derivatives of C2-substituted indan-1-ol compounds, processes for their preparation and their use are disclosed. In particular, the invention relates to compounds of the formula I and to their physiologically acceptable ...	04/06/2004
6680333	Imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to novel imidazolidine derivatives of formula I, ##STR1## wherein A, E, Z, R1, R2, R3, R4 and R5 have the meanings indicated in the claims. The compounds of formula I are...	01/20/2004
6673834	Hydroperylene derivatives Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the prophylaxis and therapy of diseases in which high blood platelet aggregations occur....	01/06/2004
6632838	Use of bissulfonamides for producing medicines for the treatment of hyperlipidemia The use of bissulfonamides for producing medicines for the treatment of hyperlipidemia. The invention relates to the use of bissulfonamides and their salts for producing medicines for the treatment of hyperlipidemia. The use of compounds of formula I ##ST...	10/14/2003
6617131	Nucleic acid molecule encoding the potassium channel protein, KCNQ5 KCNQ5, DNA encoding KCNQ5 or a polypeptide having KCNQ5 activity, related vectors, host cells and methods and a screening assay for identification of compounds which modify activity of a potassium channel KCNQ5 are described....	09/09/2003
6602699	Promotor for functional characterization of G-protein coupled receptors in the yeast saccharomyces cerevisiae The present invention relates to a promoter, to DNA fragments containing said promoter and to the use thereof, in particular in methods for identifying substances exhibiting an activating or inhibiting action on G protein-coupled receptors....	08/05/2003
6602864	Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibit...	08/05/2003
6521654	Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations including them Substituted imidazolidine derivatives of the formula I, ##STR1## in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active com...	02/18/2003
6495346	Complex-forming proteins The invention relates to a complex of specifically complex-forming proteins which are not naturally occurring, comprising the following components: a) at least one ligand specific for a target structure, b) at least one protein comprising a mutated dimeri...	12/17/2002
6482618	Self-enhancing, pharmacologically controllable expression systems The invention relates to a nucleic acid construct which constitutes a self-enhancing expression system and which comprises the following components: at least one first structural gene that encodes an active compound; at least one second structural gene that en...	11/19/2002
6472562	N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I, ##STR1## in which A, L, Y, and k have the meanings indicated in the specification and claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a stron...	10/29/2002
6469033	Use of 1-hydroxy-2-pyridones for the treatment of skin diseases Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the topical treatment of skin infections which are caused by fungi and bacteria....	10/22/2002
6455551	Use of 1-hydroxy-2-pyridones for treating mucosa diseases which are difficult to treat The compound of the formula I ##STR1## is suitable for the preparation of pharmaceuticals for the treatment of fungal disorders caused by azole-resistant fungi....	09/24/2002

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Assignee: Aventis Pharma Deutschland GmbH