Assignee: AstraZeneca UK Limited

Location: London, GB
No. of patents: 60

Number	Title	Issue Date
D659236	Inhaler	05/08/2012
8063213	Production of rosuvastatin calcium salt An improved process for the manufacture of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfony)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, Formula (1), which is useful for the production of a pharmaceutical useful in the treatm...	11/22/2011
8034932	Chemical process A process for formation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, (A chemical formula should be inserted here—please see paper copy enclosed herewith) I via a Heck reaction is described. Intermediates useful in the process and pro...	10/11/2011
RE42353	Quinazoline derivatives and pharmaceutical compositions containing them The invention relates to quinazoline derivatives of formula (1) wherein m is an integer from 1 to 2; R1 represents hydrogen, hydroxy, halogeno, nitro, trifluoromethyl, cyano, C1-3alkyl, C1-3...	05/10/2011
7888083	Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the st...	02/15/2011
7842807	Process for preparing the calcium salt of rosuvastatin An improved process for manufacture of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid calcium salt, which is useful for the production of a pharmaceutical useful in the treatment of, inter a...	11/30/2010
7816528	Preparation of aminopyrimidine compounds A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt; ...	10/19/2010
7732171	Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the st...	06/08/2010
7718812	Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivates The invention relates to a process for the conversion of group X in a 2-(6-substituted)-1,3-dioxane-4yl) acetic acid derivative according to formula 2 into a group OY in the presence of a phase transfer catalyst and an oxylating agent, by using as a phase transfer c...	05/18/2010
7671195	Process for preparing dibenzothiazepine compounds A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2′-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2′-carboxy-diphenylsulfide compound is suitably prepared by redu...	03/02/2010
7524955	Process for the preparation of pyrimidine compounds A process for the preparation of a compound of Formula (I) and intermediates useful therein are provided. The process comprises reacting a compound of formula R1—CO—CH2-E with a compound of formula R2—CHX1X2	04/28/2009
7442811	Process for the preparation of dioxane acetic acid esters Process for the preparation of an ester of formula (1), wherein R1 represents a leaving group, CN, OH or a COOR5 group, R3 and R4 each independently represent a 1-3 C alkyl group, and R2 and R5 each i...	10/28/2008
7416865	Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the st...	08/26/2008
7342005	Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 ...	03/11/2008
7304156	Preparation of aminopyrimidine compounds A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt; ...	12/04/2007
7157255	Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises ei...	01/02/2007
7125909	Sterile parenteral nutrition compositions Pharmaceutical compositions containing 2,6-diisopropylphenol (propofol) are described for use as anaesthetics. A method for their preparation is described, as their use in producing anaesthesia including induction and maintenance of general anaesthesia and se...	10/24/2006
7087602	Cinnoline derivatives and use as medicine The invention relates to the use of cinnoline derivatives of formula (I) wherein Z represents —O—, —NH—, —S— or —CH2—; m is an integer from 1 to 5; R1 represents hydrogen, hy...	08/08/2006
7041836	Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1	05/09/2006
7041087	Pre-filled syringe A pre-filled syringe comprising a glass barrel (1), a sealing member (5) fitted in a medical liquid discharge port (11) of the barrel (1), a tip member (2) mounted around the sealing member (5) on the medical liquid discharg...	05/09/2006
6943254	Synthesis of pyrazinyl pyridine-3-sulfonamide compounds A process for the manufacture of: wherein R is (1-4C)alkyl, carboxyl(1-4C)alkyl or 1,3,4-oxadiazol-2-yl comprises: (a) reaction of the diazonium salt of 3-amino-2-chloropyridine with thionyl chloride in wa...	09/13/2005
6936610	Heterocyclic derivatives The invention relates to heterocyclic derivatives of formula (I) A—B—X1—T1(R2)—L1—T2(R3)—X2—Q (I) or pharmaceutically-acceptable salts thereof, which ...	08/30/2005
6909005	One post synthesis of 2-oxazolidinone derivatives The present invention provides an improved (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-oxazolidinone product which is prepared by a method which comprises: a) forming a carbamate of formula (III), from methyl 4-nitro-(L)-phenylalaninate hydrochloride;...	06/21/2005
6828092	In vivo assays for modulators of sterol biosynthesis A method for the identification of agents which modulate sterol biosynthesis which method comprises contacting a test compound with a host cell comprising a DNA sequence which controls expression of a yeast acetoacetyl CoA thiolase gene operably linked to a reporter...	12/07/2004
6806274	Quinazoline derivatives The invention concerns quinazoline derivatives of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X	10/19/2004
6776517	Mixing apparatus and method Apparatus for mixing a number of components comprising a vessel for receiving the components, drive means for rotating or oscillating the vessel about an axis to effect mixing of the components within the vessel, and at least one spectroscopic monitoring means for r...	08/17/2004
6657076	Process for preparing methylene bisphosphonic and salts A process for the preparation of salts of substituted or unsubstituted methylene bisphosphonic acids by hydrolysing the corresponding acid ester with hydrochloric acid, removing water from the acid azeotropically prior to addition of an amine or a base to...	12/02/2003
6630321	Method for identifying a compound that modulates the function of the gene product of an essential gene A method for identifying a compound which modulates the function of the gene product of an essential gene, which method comprises providing viable cells wherein the gene is expressed under the control of a heterogenous, regulatable promoter, switching off...	10/07/2003
6566376	Diphenyl-piperidine derivative The invention provides compounds of general formula (I) ##STR1## wherein R1, R2, R3, R4, A, Q, U, V, W, X, Y and n are as defined in the specification, processes for their preparation, pharmaceutical composition...	05/20/2003
6562825	Piperazine derivatives as modulators of chemokine receptor activity The invention provides compounds of general formula (I) ##STR1## wherein R1, R2, R3, R4, R5, X, Y, Z, m and n are as defined in the specification, processes for their preparation, pharmaceutical compo...	05/13/2003
6555541	Substituted phenyl compounds with immunosuppressing activity and pharmaceutical compositions The invention provides substituted phenyl compounds of general formula ##STR1## wherein R1, T, U and Ar are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing t...	04/29/2003
6525060	Triazolo(4,5-d)pyrimidine compounds Triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation. The compounds of the invention have the formula (I) as follows: ##STR1## wherein R, X and R1 through R3 ...	02/25/2003
6517230	Mixing apparatus and method Apparatus for mixing a number of components comprising a vessel for receiving the components, drive means for rotating or oscillating the vessel about an axis to effect mixing of the components within the vessel, and at least one spectroscopic monitoring ...	02/11/2003
6479527	Bicyclic pyrrole derivatives as MCP-1 inhibitors A pharmaceutical composition comprising a compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, which is an inhibitor of monocyte chemoattractant protein-1 and wherein A and B together form an optionally substitu...	11/12/2002
6407093	1,4-Diazacycloheptane derivatives for the treatment of neurological disorders Emopamil inhibitors according to formula (I): ##STR1## wherein R, R1, m, R2 and n are as defined in the specification, useful in the treatment of neurological disorders, are disclosed. Also disclosed are pharmaceutical compositions c...	06/18/2002
6399104	Pharmaceutical compositions A dry powder layering process for preparing pharmaceutical compositions of the leukotriene antagonist zafirlukast. The process forms coated beads suitable for sprinkling on to food and drink....	06/04/2002
6344570	Substituted urea derivatives as cell adhesion inhibitors Compounds of formula (II) ##STR1## where R1 is in the para or meta position and is (A); R2 and R3 are each independently selected from hydrogen, nitro, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alk...	02/05/2002
6342765	Imidazole derivatives and their use as farnesyl protein transferase inhibitors ##STR1## The present invention relates to compounds of formula (I), wherein Ar1 represents (A) and (B) or (C); R12 and R13 are independently hydrogen or C1-4 alkyl; Ar2 is phenyl or heteroaryl; p is 0 or ...	01/29/2002
6291507	Chemical compounds A pharmaceutical composition which comprises a compound of formula (I) ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, which is an inhibitor of monocyte chemoattractant protein-1, and wherein A and B form an optionally substituted ...	09/18/2001
6251910	1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists Compounds of formula having the following stereochemistry ##STR1## wherein R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful as P2T receptor antagonists....	06/26/2001

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Assignee: AstraZeneca UK Limited