Assignee: AstraZeneca AB

Location: Sodertalje, SE
No. of patents: 914

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Number	Title	Issue Date
8183525	Method and system for analysing a dose formulation of a metered dose device One aspect of the invention features a method of analyzing dose metered devices by: spraying an aerosol from a metered dose device directly into a spray chamber of a mass spectrometer detector by firing a dose from a metered dose device, for example a pMDI, by depre...	05/22/2012
8183412	Process for the preparation of cyclopropyl carboxylic acid esters and derivatives The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the...	05/22/2012
8183385	SNAR process for preparing benzimidazole compounds Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ia-2 and their synthetic intermediates: wherein X1, X2, X5, R1, R2 and R...	05/22/2012
8178529	Imidazole substituted pyrimidines Imidazole substituted pyrimidines and pharmaceutically acceptable salts thereof; pharmaceutical formulations containing such pyrimidines; the use of such compounds in therapy; the use of such compounds for the treatment of conditions associated with glycogen synthas...	05/15/2012
8173676	Benzyl, amines, a process for their production and their use as anti-inflammatory agents The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents. ...	05/08/2012
8168221	Composition 064 A pharmaceutical composition which comprises N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulphonamide with mannitol and/or 5 microcrystalline cellulose is described. ...	05/01/2012
8163928	Heteroaryl substituted benzothiazoles The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to th...	04/24/2012
8163926	Process for the synthesis of piperidinyl sulphonate esters The present invention relates to a process for the manufacture of a compound of the Formula IIa: wherein R is a suitable sulphonate ester; from a (C1-C6)alkyl-4-piperidinecarboxylate compound of the Formula III:	04/24/2012
8163905	Compounds and their uses 708 The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for...	04/24/2012
8163724	Glucocorticosteroids, processes for their preparation, pharmaceutical compositions containing them and their use in therapy The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R...	04/24/2012
8158820	Compounds The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation. ...	04/17/2012
8158618	Dibenzothiazepine derivatives and uses thereof—424 Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a ...	04/17/2012
8153673	Metalloproteinase inhibitors Compounds of the formula (I) wherein Z is SO2(N6) or N(R7)SO2 or N(R7)SO2N(R6) useful as metalloproteinase inhibitors, especially as inhibitors of MMP12. ...	04/10/2012
8153643	Quinazoline derivatives The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6	04/10/2012
8153638	Metabotropic glutamate-receptor-potentiating isoindolones Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for th...	04/10/2012
8151793	Device and method for deaggregating powder A device for inhalation of at least one air stream carrying a dose of medicament powder is provided. The device includes a flow passage passing a powder-containing cavity. A part of said flow passage propagates along a generally flat surface region. The flat surface...	04/10/2012
8148572	Compounds The invention relates to substituted phenylacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation. ...	04/03/2012
8148406	Polymorph of N,N-diethyl-4-(3-fluorophenyl-piperidin-4-ylidene-methyl)-benzamide hydrochloride salt Polymorphs of N,N-diethyl-4-(3-fluorophenyl-piperidin-4-ylidene-methyl)-benzamide hydrochloride salt, methods of making these polymorphs and uses thereof are described. ...	04/03/2012
8148373	Compounds The present invention relates to spirocyclic amide derivatives of the formula I, pharmaceutically acceptable salts thereof, a process for their preparation, pharmaceutical compositions containing them, and their use in ther...	04/03/2012
8148372	Metabotropic glutamate receptor isoxazole ligands and their use as potentiators—286 Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical composition...	04/03/2012
8143408	N-(8-heteroaryltetrahydronaphtalene-2yl) or N-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain The present invention relates to new compounds of formula (I) and to pharmaceutical composition containing said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new...	03/27/2012
8143290	Chemical compounds 572 Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the...	03/27/2012
8143263	Therapeutic agents A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion. ...	03/27/2012
8143261	Thiazolo (4,5-D) pyrimidine compounds The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy. ...	03/27/2012
8138183	Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in d...	03/20/2012
8138172	8-oxoadenine derivatives acting as modulators of TLR7 The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the t...	03/20/2012
8129403	Chemical compounds This invention relates to novel compounds having the formula (I); and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer. ...	03/06/2012
8129393	Diarylmethyl piperazine derivatives, preparations thereof and uses thereof Compounds of general formula: as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain, depression and a...	03/06/2012
8129391	N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and salts thereof There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medic...	03/06/2012
8129380	Phthalazinone derivatives A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; X and Y are selected from CH and CH, CF and CH, CH and CF and N and CH respectively; RC	03/06/2012
8124779	Process for the preparation of esomeprazole non-salt form The present invention relates to a new process for the preparation of new crystal modifications of esomeprazole non-salt form. Further, the present invention also relates to the use of said new crystal modifications for the treatment of gastrointestinal disorders, p...	02/28/2012
8124602	Compounds for the treatment of multi-drug resistant bacterial infections The present invention relates to compounds of Formula V(A): that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as med...	02/28/2012
8119673	Compounds 148 This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containing them and...	02/21/2012
8119661	Piperidine derivatives and their use as muscarinic receptor modulators Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R2, R3, X, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compo...	02/21/2012
8114989	Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer. ...	02/14/2012
8114881	2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereo...	02/14/2012
8114435	Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a NSAID An oral pharmaceutical dosage form comprising an acid susceptible proton pump inhibitor and one or more NSAIDs in a fixed formulation, wherein the proton pump inhibitor is protected by an enteric coating layer. The fixed formulation is in the form of an enteric coat...	02/14/2012
8110566	Therapeutic agents 713 Disclosed herein are compounds of formula I in which R1, R2, R3, R4, R5, A, X, Y are as described in the specification, their use in pharmaceutical compositions and in ...	02/07/2012
8106073	Quinoline derivatives 057 The invention provides a compound of formula (I) as defined in the specification, a process for its preparation, pharmaceutical compositions containing it, a process for preparing the pharmaceutical composition, and its use in therapy. ...	01/31/2012
8106063	Pyrimidyl sulphone amide derivatives as chemokine receptor modulators A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid arthritis,...	01/31/2012

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Assignee: AstraZeneca AB