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| Number | Title | Issue Date |
| 8012692 | Elastin peptide fingerprints and analysis methods for MMP12 related to COPD Methods for producing and using protein/peptide fingerprints, allowing identification and investigation of disease-associated proteins/peptides that can be linked to specific drug targets, or to specific drug target combinations. The methods are particularly useful ... | 09/06/2011 |
| 7982038 | Ligands A radioactive compound having the formula: and pharmaceutically-acceptable salts thereof, wherein R1 and Ar are as defined in the specification, enantiomers, in vivo-hydrolysable precursors, pharmaceutical composit... | 07/19/2011 |
| 7956069 | Compounds Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein A1, A2, G1, G2 G3, R1, R2, X, Y, Z, m, n and p are as defined in th... | 06/07/2011 |
| 7846955 | Salt The invention provides [2-(4-chloro-benzyloxy)-ethyl]-[2-((R)-cyclohexyl-hydroxy-phenyl-methyl)-oxazol-5-yl-methyl]-dimethyl-ammonium napadisylate, pharmaceutical compositions containing it, and its use in therapy. ... | 12/07/2010 |
| 7842803 | Nicotinic acetylcholine receptor ligands 101 Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making,... | 11/30/2010 |
| 7786115 | Amide derivatives The invention concerns a compound of the Formula I wherein m is 0-2 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R2 is halogeno, trifluoromethyl o... | 08/31/2010 |
| 7772432 | Amidobenzamide derivatives which are useful as cytokine inhibitors The invention concerns amide derivatives of the Formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluoromethyl, cyano, (1-6C)alkyl, (1-6C)alkoxy, halog... | 08/10/2010 |
| 7772403 | Process to prepare sulfonyl chloride derivatives A novel process for the preparation of hydantoin sulfonyl chlorides of general formula (I) wherein R and n are as specified in the description, and certain novel intermediates thereto, are disclosed. ... | 08/10/2010 |
| 7741360 | Bi-aryl or aryl-heteroaryl substituted indoles The present invention relates to substituted indoles of Formula (I) useful as pharmaceutical compounds for treating respiratory disorders. ... | 06/22/2010 |
| 7737135 | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their... | 06/15/2010 |
| 7728030 | Chemical compounds 572 Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the... | 06/01/2010 |
| 7723373 | Indole-3-sulphur derivatives The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders. ... | 05/25/2010 |
| 7709521 | Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders. ... | 05/04/2010 |
| 7709511 | Benzothiazolone derivatives The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in ... | 05/04/2010 |
| 7709500 | Chemical compounds The invention provides compounds of formula (I): wherein: X is CH2, O, S(O)2 or NR10; Y is a bond, CH2, NR35, CH2NH, CH2NHC(O), CH(OH), CH(NHCOR | 05/04/2010 |
| 7700782 | Compounds 569 The present invention provides compounds of formula (I) wherein Ra, Rb, R1, R2, R3, R4, R5, R6 and R29 are as defined in the... | 04/20/2010 |
| 7700604 | Hydantoin derivatives as metalloproteinase inhibitors The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutica... | 04/20/2010 |
| 7687535 | Substituted 3-sulfur indoles The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders. ... | 03/30/2010 |
| 7666892 | Metalloproteinase inhibitors Compounds of the formula (I) wherein Z is SO2(N6) or N(R7)SO2 or N(R7)SO2N(R6) useful as metalloproteinase inhibitors, especially as inhibitors of MMP12. ... | 02/23/2010 |
| 7662845 | 2,5-Dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase MMP12 The invention provides compounds of formula in which L, X, Y, Z1, Z2, R1, R2, R3 and G2 have the meanings defined in the specification; processes for their p... | 02/16/2010 |
| 7655664 | Hydantoin derivatives as metalloproteinase inhibitors The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutica... | 02/02/2010 |
| 7648992 | Hydantoin derivatives for the treatment of obstructive airway diseases The invention provides compounds of formula (I), wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and t... | 01/19/2010 |
| 7625934 | Metalloproteinase inhibitors Compounds of the formula (I) wherein z is SO2 or SO, useful as metalloproteinase inhibitors, especially as inhibitors of MMP12. ... | 12/01/2009 |
| 7605159 | Cathepsin cysteine protease inhibitors and their use The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsi... | 10/20/2009 |
| 7582644 | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid arthritis,... | 09/01/2009 |
| 7553868 | Thiophene carboxamides as inhibitors of the enzyme IKK-2 The invention relates to thiophene carboxamides of formula (I) wherein Ar, R1, R2, R3, R4, R5, m and n are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containi... | 06/30/2009 |
| 7528156 | Compounds The invention provides compounds of general formula (D wherein m, n, Q, Z1, Z2, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. | 05/05/2009 |
| 7524856 | Tricyclic spiroderivatives as modulators of chemokine receptor activity The invention provides compounds of formula (I) wherein m, R1, n, R2, q, p, X, Y, R3, R4, t and, R5 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing th... | 04/28/2009 |
| 7517989 | Piperidine derivatives useful as modulators of chemokine receptor activity The present invention provides a compound of formula (I), wherein: Z is (A) OR (B) and wherein the remaining variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of achemokine (such as CCR3) or ... | 04/14/2009 |
| 7514471 | Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α (PPAR) The present invention provides the S enantiomer of a compound of formula (I) wherein n is 1 or 2 as well as pharmaceutically acceptable salts, solvates, crystalline forms and prodrugs thereof, to processes for preparing such compounds, to their the utility in treati... | 04/07/2009 |
| 7498338 | Compounds The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, t, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparatio... | 03/03/2009 |
| 7495013 | Chemical compounds The present invention relates to compounds of formula (I): The variables recited in formula (I) are defined in the specification. The present invention also relates to processes of preparing compounds of formula (I) and use... | 02/24/2009 |
| 7488844 | Therapeutic agents The present invention provides a compound of formula I processes for preparing such compounds, their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeuti... | 02/10/2009 |
| 7485644 | N-{'4-substituted piperazine-1-sulfonylmethylalkyl}-n-hydroxyfomamide compounds as metalloproteinase inhibitors The invention provides compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein ring B represents a monocyclic aryl ring having six ring atoms or a monocyclic heteroaryl ring having up to six ring atoms and containing one ... | 02/03/2009 |
| 7482363 | Piperidine derivatives useful as modulators of chemokine receptor activity The present invention provides a compound of formula (I), wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state. | 01/27/2009 |
| 7482355 | Pyrimidine derivatives as modulators of chemokine receptor activity Compounds of formula (1), pharmaceutically acceptable salts, solvates and in vivo hydrolysable esters thereof, have activity as pharmaceuticals, in particular as modulators of chemokine receptor (especially CXCR2) activity, and may be in the treatment (therapeutic o... | 01/27/2009 |
| 7462644 | Therapeutic agents The present invention provides the S enantiomer of a compound of formula I wherein R1 represents chloro, trifluoromethyl or trifluoromethoxy, R2 represents H or fluoro and R3 represents a C | 12/09/2008 |
| 7427631 | Metalloproteinase inhibitors Compounds of the formula (I) wherein z is SO2 or SO, useful as metalloproteinase inhibitors, especially as inhibitors of MMP12. ... | 09/23/2008 |
| 7408065 | P2Xreceptor antagonists and their use The invention provides compounds of formula (IA), processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. ... | 08/05/2008 |
| 7393854 | Thienopyrimidinedinones and their use in modulation of autoimmune disease The invention relates to thienopyrimidinediones of formula (I): wherein: R1, R2, Q are as defined in the specification, and Ar and Ar2 are selected from certain aromatic ring sy... | 07/01/2008 |
