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| Number | Title | Issue Date |
| 6485964 | TRANSGENIC MAMMALS LACKING EXPRESSION OF ERYTHROPOIETIN OR OF ERYTHROPOIETIN RECEPTOR, TRANSGENIC MAMMALS EXPRESSING CHIMERIC ERYTHROPOIETIN RECEPTORS, CONSTRUCTS FOR PRODUCING THE TRANSGENIC MAMMALS AND USES THEREFOR Transgenic nonhuman mammals, such as transgenic mice, which lack erythropoietin expression, in which the erythropoietin receptor is deleted, which carry a heterologous erythropoietin receptor (e.g., a chimeric receptor); constructs useful for producing su... | 11/26/2002 |
| 5776718 | Reversible protease inhibitors The invention relates to novel reversible protease inhibitors. The inhibitors are specific to cysteine proteases.... | 07/07/1998 |
| 5703792 | Three dimensional measurement of molecular diversity A method and system for selecting molecules or molecular parts for screening. A base set of molecules on which chemical tests are to be performed is defined, and once defined, the base set may be extended by selecting molecules which are determined to max... | 12/30/1997 |
| 5693515 | Metal complexed serine protease inhibitors Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent c... | 12/02/1997 |
| 5656660 | Compositions and methods for treating mast-cell mediated conditions The present invention describes compounds, methods and compositions effective to treat mast cell mediated inflammatory conditions, such as conjunctivitis, asthma and allergic rhinitis. The compounds of the invention comprise novel mono- and di-aminomethyl... | 08/12/1997 |
| 5585275 | Pilot apparatus for peptide synthesis and screening Method and apparatus for simple and rapid preparation of reusable, addressable surface-immobilized arrays of biomolecules (libraries) used for screening for interaction with any biologically significant target. A special plate having on or in its surface ... | 12/17/1996 |
| 5576220 | Thin film HPMP matrix systems and methods for constructing and displaying ligands The invention relates to methods and systems of unhindered construction and display of tethered organic ligand molecules, and more particularly to preparation and use of thin film, substantially non-crosslinked hydrophilic polar multi-functionalized polym... | 11/19/1996 |
| 5567602 | Recombinant production of chymase The instant invention is directed to recombinant production of functionally active chymase. "Functionally active" as used herein refers to the ability to exhibit one or more functional activities of a full-length wild-type chymase protein. In a preferred ... | 10/22/1996 |
| 5526281 | Machine-learning approach to modeling biological activity for molecular design and to modeling other characteristics Explicit representation of molecular shape of molecules is combined with neural network learning methods to provide models with high predictive ability that generalize to different chemical classes where structurally diverse molecules exhibiting similar s... | 06/11/1996 |
| 5525623 | Compositions and methods for the treatment of immunomediated inflammatory disorders Compositions and methods for the prevention and treatment of immunomediated inflammatory disorders, especially for those disorders associated with the respiratory tract, are provided. More particularly, a tryptase inhibitor, typically a hydroxyaroyl or hy... | 06/11/1996 |
