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| Number | Title | Issue Date |
| 7105695 | Synthesis of combretastatin A-2 prodrugs The original synthesis of combretastatin A-2 (1a) was modified to provide an efficient scale-up procedure for obtaining this antineoplastic stilbene. Subsequent conversion to a useful prodrug was accomplished by phosphorylation employing in situ formation of dibenzy... | 09/12/2006 |
| 7012124 | Solid polymeric electrolytes for lithium batteries Novel conductive polyanionic polymers and methods for their preparion are provided. The polyanionic polymers comprise repeating units of weakly-coordinating anionic groups chemically linked to polymer chains. The polymer chains in turn comprise repeating spacer grou... | 03/14/2006 |
| 6998413 | Treatment of neoplasms with yujungamycins Yungamycin A has been demonstrated to have unexpected in vivo anticancer activity. New compounds Yungamycin B and C are also disclosed, and have been demonstrated to be specific for DT-diaphorase, as well as to have in vivo anticancer activity. ... | 02/14/2006 |
| 6943194 | Synthesis of phenstatin and prodrugs thereof A newly discovered antineoplastic compound denominated “phenstatin” is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was converted to the sodium phosphate prodrug (3d) by a dibenzylphosphite phospho... | 09/13/2005 |
| 6936708 | Expression of Alfin 1 and methods for producing transgenic plants having increased root growth and root specific gene activation Alfin1 cDNA encodes a putative transcription factor associated with salt tolerance in alfalfa (Medicago sativa L). The recombinant protein binds DNA in a sequence specific manner, including promoter fragments of the salt inducible gene MsPRP2. Alfin1 function... | 08/30/2005 |
| 6846840 | Cytotoxic N-unsubstituted indoles and cyclopent(B)indoles and method of making and using same The merits of N-unsubstituted indoles and cyclopent[b]indoles as DNA-directed reductive alkylating agents are described. These systems represent a significant departure from N-substituted and pyrrolo[1,2-α] fused systems such as the mitomycins and mitosenes. The cy... | 01/25/2005 |
| 6686445 | Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same A composition of matter, denominated herein as 12a-r, having the structural formula set forth below: ##STR1## wherein R is selected from the group consisting of: a) R=NHPh; b) R=NHCH2 Ph; c) R=NH(CH2)2 Ph; d) R=NH(CH2 | 02/03/2004 |
| 6620911 | Anti-cryptococcal peptides Antifungals based on dolasatin 10 and four structural modifications thereof (herein "peptides") and methods of treating a host afflicted with a fungi-induced infection are herein described. In broth macrodilution assays, these peptides were fungicidal for... | 09/16/2003 |
| 6304784 | Flexible probing device and methods for manufacturing the same An improved probing device includes: an elongated, substantially cylindrical flexible fiber having a non-conducting outer surface; one or more circuits disposed on the outer surface of the fiber for simultaneously providing an electrical signal path to an... | 10/16/2001 |
| 6030199 | Apparatus for freeform fabrication of a three-dimensional object An improved apparatus and method for forming a three-dimensional object by planar deposition of forming materials includes containers for holding molten forming materials, mechanical piston or screw members in the containers for pressurizing the molten fo... | 02/29/2000 |
