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Patent No. 5508049

Pizza Pie With Concentric Rings of Crust

A pizza mold for forming a plurality of concentric raised ridges of dough (i.e., crust) on the surface of a pizza pie.

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Assignee: Aradigm Corporation


Location: Hayward, CA
No. of patents: 106

1      
NumberTitleIssue Date
8119156Dual action, inhaled formulations providing both an immediate and sustained release profile
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described. ...
02/21/2012
8071127Dual action, inhaled formulations providing both an immediate and sustained release profile
Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described. ...
12/06/2011
7958887Nozzle pore configuration for intrapulmonary delivery of aerosolized formulations
The present invention describes the configuration of a porous sheet for improving the efficiency for generating an aerosol from a liquid formulation. This aerosolized liquid formulation can be used for intrapulmonary delivery of pharmaceutically active drugs and dia...
06/14/2011
7767930Method and system for LASER machining
The invention provides a method of rapidly machining multiple, often similar or nearly identical, features using a LASER machining system. During LASER machining, light of a wavelength and intensity that will modify the workpiece to be machined is directed at the wo...
08/03/2010
7490603Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is improved rela...
02/17/2009
7448375Method of treating diabetes mellitus in a patient
Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each t...
11/11/2008
7316360Pore structures for reduced pressure aerosolization
A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which th...
01/08/2008
7301621Method and device for non-destructive analysis of perforations in a material
Method for fabricating and inspecting small holes in a material are disclosed. The method includes directing light onto the material and through the holes formed in the material, and then collecting the light passing through the holes in the material onto a detector...
11/27/2007
7258850Methods and compositions for treating erectile dysfunction
Methods are provided for increasing libido and/or treating erectile dysfunction in a man. The methods include the administration of a formulation testosterone alone, another fast-acting drug to treat erectile dysfunction or a combination of the testosterone and the ...
08/21/2007
7244714Methods of delivering aerosolized polynucleotides to the respiratory tract
Methods and devices for delivering aerosolized formulations containing polynucleotides to specified regions within a subject's respiratory tract are disclosed. The methods find use in the delivery of ribozymes, antisense polynucleotides, and DNA and RNA expression v...
07/17/2007
7150297Method and apparatus for filling needleless injector capsules
A method is provided for filling needleless injector capsules with liquid drug, which eliminates or reduces trapped air bubbles in the drug. A two-stage vacuum method is disclosed which enables the capsule to be evacuated rapidly to very low pressure prior to fillin...
12/19/2006
7148960Method and device for non-destructive analysis of perforations in a material
Method for fabricating and inspecting small holes in a material are disclosed. The method includes directing light onto the material and through the holes formed in the material, and then collecting the light passing through the holes in the material onto a detector...
12/12/2006
7143766Temperature controlling device for aerosol drug delivery
A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation. Warming the air of an aerosol makes it possible to reduce the diameter of aerosol particles produced by an aerosol generation device. Additionally, warm...
12/05/2006
7028686Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume
Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each t...
04/18/2006
7021309Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is improved rela...
04/04/2006
6933026Method to reduce damage caused by irradiation of halogenated polymers
A method for producing a polymeric film resistant to degradation during sterilization such as gamma irradiation is presented. The method includes the steps of minimizing the number of free radicals formed during sterilization through use of an inert gas and a reacta...
08/23/2005
6874507System for effecting smoking cessation
A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aer...
04/05/2005
6855909Pore structures for reduced pressure aerosolization
A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which th...
02/15/2005
6845216Temperature controlling device for aerosol drug delivery
A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation is described. Warming the air of an aerosol makes it possible to reduce the size of aerosol particles produced by an aerosol generation device. Additiona...
01/18/2005
6830744Compositions methods and systems for pulmonary delivery of recombinant human interferon alpha-2b
Stable aqueous formulations which are free of products derived from human or animal origin and which maintain high biological activity and high chemical and physical stability of alpha-type interferon for an extended period of time. Methods of producing stable aeros...
12/14/2004
6799576System for effecting smoking cessation
A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aer...
10/05/2004
6732943Method of generating uniform pores in thin polymer films
Methods of generating pores in thin sheets of material, typically thin polymer films, are provided. The methods allow for generation of pores which uniformly penetrate the material. The method comprises laminating a thick film onto a thin film, then directing a lase...
05/11/2004
6732954Pore structures for reduced pressure aerosolization
A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which th...
05/11/2004
6694975Temperature controlling device for aerosol drug delivery
A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation. Warming the air of an aerosol makes it possible to reduce the diameter of aerosol particles produced by an aerosol generation device. Additio...
02/24/2004
6689986Pore structures for reduced pressure aerosolization
A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, ...
02/10/2004
6688304Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume
Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the pat...
02/10/2004
6681810Filling device for a needleless injector cartridge
A needleless injector cartridge has an adaptor for introducing fluid from a filling device into an orifice of the cartridge. The adaptor has a frangible connection which is broken to allow removal of the filling device after the cartridge is filled with t...
01/27/2004
6673038Needleless injector cartridge
A needleless injector cartridge, comprises an injection component (1) defining a void (17) therein for receiving medicament, and having an injection discharge orifice communicating with the void. The cartridge further comprises a transfer device (2) compr...
01/06/2004
6647987Insulin delivery enhanced by coached breathing
The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of...
11/18/2003
6632419Increasing libido in humans via acute testosterone administration
The libido of adult human female patients is increased by the bolus delivery of a testosterone which is preferably dihydrotestosterone. The formulation is preferably aerosolized and inhaled into a patient's lungs where particles of testosterone deposits o...
10/14/2003
6629526Temperature controlling device for aerosol drug delivery
A portable air temperature controlling device useful for warming air surrounding an aerosolized drug formulation is described. Warming the air of an aerosol makes it possible to reduce the size of aerosol particles produced by an aerosol generation device...
10/07/2003
6624885Method and device for non-destructive analysis of perforation in a material
A method for inspecting small holes in a material is disclosed. The method comprises directing a light source through the holes in the material, and then focusing the light passing through the material onto a CCD detector. The focusing techniques allow fo...
09/23/2003
6551542Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs
A method for producing a nozzle useful in generating a fine aerosol for delivery of therapeutic or diagnostic agents is provided. The method comprises focusing a laser source onto a thin, preferably flexible material so as to form pores substantially thro...
04/22/2003
6543442Aerosol-forming porous membrane with certain pore structure
A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positi...
04/08/2003
6443151Fluid velocity-sensitive trigger mechanism
The invention provides a triggering mechanism for actuating a trigger signal in response to a pre-determined rate of fluid flow through the mechanism. Triggering mechanism generally includes a sliding piston within an air channel, held in place by a resis...
09/03/2002
6431166Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...
08/13/2002
6431167Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...
08/13/2002
6428769Acute testosterone administration
The libido of adult human female patients is increased by the intrapulmonary delivery of testosterone. A formulation of testosterone is aerosolized and inhaled into a patient's lungs where particles of testosterone deposits on lung tissue and then enter t...
08/06/2002
6427681Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is im...
08/06/2002
6408854Insulin delivery enhanced by coached breathing
The need for the delivery of insulin by injection can be reduced or eliminated by a method whereby an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of...
06/25/2002
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