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| Number | Title | Issue Date |
| 7575747 | Aβ binding molecules The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarity determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prev... | 08/18/2009 |
| 7435799 | TNF-α binding molecules The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation... | 10/14/2008 |
| 7175996 | Methods of optimizing antibody variable region binding affinity The present invention relates to compositions and methods of producing higher affinity molecules, and in particular, higher affinity antibodies. Specifically, the invention contemplates methods of mutagenesis to create a population of oligonucleotides coding for alt... | 02/13/2007 |
| 7101978 | TNF-α binding molecules The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation... | 09/05/2006 |
| 7070973 | Butyrylcholinesterase variants and methods of use The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries comprising butyrylcholinesterase variants having at least one amino aci... | 07/04/2006 |
| 7049121 | Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use The invention provides twenty-one butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate a... | 05/23/2006 |
| 6893845 | Surface expression libraries of heteromeric receptors The invention is directed to a composition of matter consisiting of a plurality of procaryotic cells. The plurality of procaryotic cells contain diverse combinations of first and second DNA sequences encoding first and second polypeptides which form a heteromeric re... | 05/17/2005 |
| 6787638 | Tumor specific human monoclonal antibodies and methods of use The invention provides tumor-specific human monoclonal antibodies and functional fragments. Also provided are nucleic acids encoding tumor-specific human monoclonal antibodies and functional fragments. A method for reducing neoplastic cell proliferation is also prov... | 09/07/2004 |
