Bizarre Patents
Vehicular Impact Signaling Device
An apparatus for the deployment of a visible plume to alert other motorists that a proximate motor vehicle has been involved in a collision.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8178296 | Methods and reagents for preserving RNA in cell and tissue samples This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (RNA) content of samples from degradation prior to RNA isolation. This preservation may be accomplished without ul... | 05/15/2012 |
| 8165821 | System and methods for indel identification using short read sequencing Systems, methods, and analytical approaches for short read sequence assembly and for the detection of insertions and deletions (indels) in a reference genome. A method suitable for software implementation is presented in which indels may be readily identified in a c... | 04/24/2012 |
| 8163897 | 5-bromo-2′-deoxy-uridine labeled nucleotide triphosphates and nucleic acid probes and methods of making and using the same 5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide triphosphate and the BrdU moiety. The linker can be cleavable or non-cl... | 04/24/2012 |
| 8163538 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality ... | 04/24/2012 |
| 8163150 | Electrowetting dispensing devices and related methods A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing... | 04/24/2012 |
| 8153401 | Method for direct amplification from crude nucleic acid samples The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the direct amplification of the nucleic acids in a crude sample with minima... | 04/10/2012 |
| 8147770 | Microfluidic device including a dissolvable structure for flow control A diagnostic device is provided that includes a plurality of retainment regions, with the retainment regions that are separated by at least one dissolvable barrier. The retainment regions can be interconnected through at least one fluid processing passageway. A reta... | 04/03/2012 |
| 8131493 | Method of automated calibration and diagnosis of laboratory instruments Method and system providing an automated workflow for installing and/or calibrating laboratory equipment. The workflow empowers an end user to perform installation and calibration thereby reducing the costs associated with such activities. The automated workflow tau... | 03/06/2012 |
| 8129529 | UV excitable fluorescent energy transfer dyes Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted fro... | 03/06/2012 |
| 8124746 | Methods and kits using extended rhodamine dyes Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the st... | 02/28/2012 |
| 8119423 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 02/21/2012 |
| 8102529 | Refractive index matching in capillary illumination System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light. ... | 01/24/2012 |
| 8101057 | Concentration and cleanup of nucleic acid samples Methods and devices are described for concentration and cleanup of samples containing bio-molecule analytes (e.g., polynucleotides, such as DNA, RNA, PNA). Various embodiments provide for pH-mediated sample concentration and cleanup of nucleic acid samples with chan... | 01/24/2012 |
| 8093367 | Preparation and isolation of 5′ capped mRNA The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool ... | 01/10/2012 |
| 8090543 | Computer algorithm for automatic allele determination from fluorometer genotyping device The present invention provides methods and systems for an automated method of identifying allele values from data files derived from processed fluorophore emissions detected during the observation of fluorophore labeled nucleotide probes used in analyzing polymorphi... | 01/03/2012 |
| 8084260 | Spectral calibration method and system for multiple instruments Implementations of the present invention describe an apparatus for generating calibration factors for a spectral detector instrument. The calibration factors are derived from a calibration plate containing one or more spectral species in each well of the calibration... | 12/27/2011 |
| 8083917 | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field A method is disclosed for effecting the concentration of a polar analyte in an alternating electric field. In the method, a relative translation of the polar analyte and an alternating electric field along a translation path is effected. A portion of the polar analy... | 12/27/2011 |
| 8067226 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 11/29/2011 |
| 8067165 | Binary probe and clamp composition and methods for target hybridization detection Binary probe and clamp compositions conduct methods for target hybridization detection. Where the probe is a substrate for exonuclease cleavage, the composition provides quantitation and detection of PCR products, by real-time and end-point measurements. Where the p... | 11/29/2011 |
| 8067159 | Methods of detecting amplified product A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma,... | 11/29/2011 |
| 8062883 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality ... | 11/22/2011 |
| 8062611 | Fluid processing device including composite material flow modulator A fluid processing device is provided that includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions. The barrier includes a mixture of a seque... | 11/22/2011 |
| 8058255 | Methods and compositions concerning siRNA's as mediators of RNA interference The present invention concerns an isolated siRNA of from about 5 to about 20 nucleotides that mediates RNA interference. Also disclosed are methods of reducing expression of a target gene in a cell comprising obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12... | 11/15/2011 |
| 8058030 | Methods of producing and sequencing modified polynucleotides The present invention encompasses methods for producing a modified polynucleotide sequence that comprises a (e.g., one or more) phosphorothiolate linkage, methods for determining a polynucleotide sequence comprising a (e.g., one or more) phosphorothiolate linkage, a... | 11/15/2011 |
| 8049623 | Methods and systems for using RFID in biological field Biological reagent carrier devices and methods are disclosed, which employ RFID techniques to associate information with biological reagents. ... | 11/01/2011 |
| 8040619 | Optical camera alignment A camera alignment system that can enable alignment in at least one of three planes and about an axis of at least one of the planes. An alignment mount can mate to a camera and lens. The alignment mount can comprise a mechanism to adjust the camera relative to the l... | 10/18/2011 |
| 8039234 | Methods, panels of identification markers, and kits for identifying forensic samples Methods for identifying forensic samples using panels of markers and gene expression profiling, including without limitation, mRNA profiling, miRNA profiling, or both, are disclosed. Panels of markers for identifying certain tissue samples and certain body fluid sam... | 10/18/2011 |
| 8036832 | Automatic threshold setting and baseline determination for real-time PCR The invention discloses a system and methods for quantitating the presence of nucleic acid sequences by evaluation of amplification data generated using real-time PCR. In one aspect, the methods may be adapted to identify a threshold and threshold cycle for one or m... | 10/11/2011 |
| 8020790 | Biological sample disruption techniques Improved ball mill disruption techniques. In different embodiments, disrupting particles that are not substantially spherical are used. In other embodiments, roughened disrupting particles are used. In other embodiments, larger disrupting particles are used. In each... | 09/20/2011 |
| 8017332 | Magnetic method for recovering nucleic acid from a mixed cell suspension A method for selectively recovering nucleic acid from a first cell type in a sample containing cells of at least a first cell type and a second cell type, and a cell suspension medium comprising extracellular impurities, is provided. The method entails combining the... | 09/13/2011 |
| 8012691 | Multiplex compositions and methods for quantification of human nuclear DNA and human male DNA and detection of PCR inhibitors The invention relates to a method for simultaneous quantification of human nuclear DNA and human male DNA in a biological sample while also detecting the presence of PCR inhibitors in a single reaction. The multiplex quantification method also provides a ratio of hu... | 09/06/2011 |
| 8012685 | Detection of analytes and nucleic acids Methods of detecting at least one analyte and at least one nucleic acid in a sample are provided. Reagents for carrying out the methods are also provided. ... | 09/06/2011 |
| 8012431 | Closing blade for deformable valve in a microfluidic device and method A microfluidic manipulation system is provided that includes a blade for manipulating deformable material and at least one movable support that is capable of moving the blade into contact with a microfluidic device including a deformable feature. When the microfluid... | 09/06/2011 |
| 8008010 | Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor Ligation-enhanced nucleic acid detection assay embodiments for detection of RNA or DNA are described. The assay embodiments rely on ligation of chimeric oligonucleotide probes to generate a template for amplification and detection. The assay embodiments are substant... | 08/30/2011 |
| 8007733 | Non-contact radiant heating and temperature sensing device for a chemical reaction chamber An apparatus and methods are provided for heating and sensing the temperature of a chemical reaction chamber without direct physical contact between a heating device and the reaction chamber, or between a temperature sensor and the reaction chamber. A plurality of c... | 08/30/2011 |
| 8005628 | Systems and methods for baseline correction using non-linear normalization Systems and methods for normalizing detected emission data collected in real-time polymerase chain reaction (RT-PCR) and other reactions, are provided. In some embodiments, a sample plate can be loaded with a fluorescent dye and subjected to a real-time PCR reaction... | 08/23/2011 |
| 8003769 | Dye-labeled ribonucleotide triphosphates The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction. ... | 08/23/2011 |
| 8003767 | Sulfonated [8,9]benzophenoxazine dyes and the use of their labelled conjugates Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a variety of contexts, including cell surface assays employing intact, l... | 08/23/2011 |
| 7998706 | Propargyl substituted nucleoside compounds and methods Disclosed, among other things, are compounds having the structure wherein X comprises a bond or a linker, LABEL comprises at least one detectable label, W1 taken alone is —H or —OH, W2 is —OH or ... | 08/16/2011 |
| 7985602 | Fluorescent dye compounds, conjugates and uses thereof The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof. ... | 07/26/2011 |
