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| Number | Title | Issue Date |
| 7501284 | Apparatus and method for specific release of captured extension products Apparatus and methods for separating different polynucleotide populations in a mixture are provided, wherein different polynucleotides or polynucleotide populations are captured on different solid support. After hybridization, polynucleotides are selectively release... | 03/10/2009 |
| 7494819 | Electrochemiluminescence electrode Disclosed is a bipolar electrode useful for ECL assays and a method for using the same. ... | 02/24/2009 |
| 7491924 | Combination reader An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus includes a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least ... | 02/17/2009 |
| 7491367 | System and method for providing a standardized state interface for instrumentation An instrumentation interface that provides a standardized states of a plurality of devices to a control system. Coordinating the operation of the plurality of devices in an analytical system is simplified by allowing the control system to perform in terms of simplif... | 02/17/2009 |
| 7486396 | Electrophoretic system with multi-notch filter and laser excitation source Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecti... | 02/03/2009 |
| 7473891 | System and methods for improving signal/noise ratio for signal detectors A method and system for characterizing and quantifying various error and calibration components of signals associated with photo-detectors. By varying the detector operational parameters such as input light intensity and integration times, measured signals can be an... | 01/06/2009 |
| 7473341 | Denaturant-free electrophoresis of biological molecules under high temperature conditions The present invention relates to a method of separating a sample comprising biological compounds, such as nucleic acids. The nucleic acids are subjected to electrophoresis using a matrix that is essentially free of denaturants and having at least one random, linear ... | 01/06/2009 |
| 7454988 | Method for fluid sampling using electrically controlled droplets The present disclosure relates to a method for sampling a fluid, such as air. As fluid flows through a device, a scrubbing liquid is positioned in a pattern to contact the fluid and constituents in the fluid are transferred to in the liquid. ... | 11/25/2008 |
| 7445901 | Nuclease inhibitor cocktail Methods and compositions for inhibiting and/or inactivating nucleases by employing nuclease inhibitors are provided. The nuclease inhibitors comprise anti-nuclease antibodies and non-antibody nuclease inhibitors. The anti-nuclease antibodies of the present invention... | 11/04/2008 |
| 7435545 | Method for sizing polynucleotides using electrophoresis with non-DNA size standards According to a method of determining a size of a sample polynucleotide, a sample polynucleotide is subjected to electrophoresis in the presence of a fluorescent compound having a first fluorescence spectrum. Detection of light of the first fluorescence spectrum is i... | 10/14/2008 |
| 7432058 | Methods of labeling nucleic acids with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 10/07/2008 |
| 7429651 | Fluorescent nucleobase conjugates having anionic linkers Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such a... | 09/30/2008 |
| 7427479 | Methods and kits for identifying target nucleotides in mixed populations Ligation-based methods and kits are disclosed for identifying at least two target nucleotides in a mixed population sample, that is a sample that contains or potentially contains target nucleic acid sequences from more than one source. Typically, two ligation reacti... | 09/23/2008 |
| 7423251 | System and methods for dynamic range extension using variable length integration time sampling A photo-detector generated signal is measured as a sample set comprising a long signal and a short signal. The short signal is scaled to the value of the long signal if the long signal exceeds a dynamic range associated with the photo detector. In one embodiment, th... | 09/09/2008 |
| 7423255 | System and methods for dynamic range extension using variable length integration time sampling A photo-detector generated signal is measured as a sample set comprising a long signal and a short signal. The short signal is scaled to the value of the long signal if the long signal exceeds a dynamic range associated with the photo detector. In one embodiment, th... | 09/09/2008 |
| 7423750 | Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion Methods and optical systems for scanning of a target sample, including methods and systems using a low mass scan head and methods and systems for conducting a scanned optically transduced assay where the scanning includes at least one first relative angular motion a... | 09/09/2008 |
| 7410793 | Optical instrument including excitation source An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, ... | 08/12/2008 |
| 7407798 | Lens assembly for biological testing The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of biological samples, and a lens having a plurality of focusing lens segmen... | 08/05/2008 |
| 7407630 | High density plate filler A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an assay input layer having a first surface and an opposing second surface. The assay input layer can comprise... | 08/05/2008 |
| 7408051 | Modified oligonucleotides and applications thereof Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof. ... | 08/05/2008 |
| 7407747 | Method for drying dye-terminator sequencing reagents A dry composition comprising a nucleotide linked to a fluorescent dye is provided. A method of making a dry composition comprising the step of drying a solution comprising a nucleotide linked to a fluorescent dye is provided. A method is provided for performing a re... | 08/05/2008 |
| 7405823 | Signal noise reduction for imaging in biological analysis A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contributio... | 07/29/2008 |
| 7406385 | System and method for consensus-calling with per-base quality values for sample assemblies The present teachings disclose a method for evaluation of a polynucleotide sequence using a consensus-based analysis approach. The sequence analysis method utilizes quality values for a plurality of aligned sequence fragments to identify consensus basecalls and calc... | 07/29/2008 |
| 7402671 | UV excitable fluorescent energy transfer dyes Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted fro... | 07/22/2008 |
| 7399614 | 5-methylcytosine detection, compositions and methods therefor Compositions and methods for detecting 5-methylcytosine in a nucleic acid are disclosed. A 5-methylcytosine discriminator, which is a deoxyribonucleosidetriphosphate comprising a cytosine-pairing moiety such as a guanosine and a moiety which hinders hydrogen bonding... | 07/15/2008 |
| 7399854 | Regents labeled with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 07/15/2008 |
| 7398171 | Automated quality control method and system for genetic analysis Aspects of the present invention describe a method and apparatus for automating quality control for gene expression data. A computer based device receives gene expression data associated with a spectral species and genetic sample in each well of a plate. Gene expres... | 07/08/2008 |
| 7394943 | Methods, software, and apparatus for focusing an optical system using computer image analysis Methods, software, and apparatus for focusing an image in biological instrument are disclosed. Focusing elements are moved to various focus positions within a focus element travel range, and sample images are captured at the various focus positions. The sample image... | 07/01/2008 |
| 7393681 | System and method for electroporating a sample A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the ... | 07/01/2008 |
| 7388664 | Methods for improving the performance of a detector A system and method for allowing adjustments of various parameters associated with the operation of charge-coupled devices adapted for use in biological analysis devices. Gate voltage signal applied to the CCDs can be adjusted to advantageously affect the manner in ... | 06/17/2008 |
| 7388092 | Oligonucleotides and analogs labeled with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 06/17/2008 |
| 7387891 | Optical instrument including excitation source An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed along a beam path between the light source and the reaction regions to... | 06/17/2008 |
| 7384525 | Electrophoretic analysis system having in-situ calibration An electrophoretic system having a plurality of separation lanes is provided with an automatic calibration feature in which each lane is separately calibrated. For each lane, the calibration coefficients map a spectrum of received channel intensities onto values ref... | 06/10/2008 |
| 7384606 | Bead dispensing system A bead dispensing system is provided for delivering small amounts of substances onto substrates. The system can include, for example, a movable support structure having an array of spaced-apart projections depending from its lower side. An attraction source, such as... | 06/10/2008 |
| 7382258 | Sample carrier device incorporating radio frequency identification, and method An apparatus for associating information with a carrier and/or at least one biological reagent is provided. The apparatus can include a carrier adapted to retain at least one biological reagent and at least one non-silicon Radio Frequency Identification Tag (RFID). ... | 06/03/2008 |
| 7381570 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 06/03/2008 |
| 7381569 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 06/03/2008 |
| 7381315 | Multi-channel analyte-separation device employing side-entry excitation A side-entry excitation arrangement is provided with a multi-channel analyte-separation device. In various embodiments, a plurality of channels are disposed in an array, with a laser disposed to direct an excitation beam of light along a beam path that crosses the l... | 06/03/2008 |
| 7381571 | Device and method for analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 06/03/2008 |
| 7379823 | System and method for discovery of biological instruments A system and methods for integrating laboratory instrumentation and applications to provide a unified control and coordination architecture under a common interface. The system provides mechanisms for detection of various hardware and software components wherein the... | 05/27/2008 |
