Assignee: Amgen Inc.

Location: Thousand Oaks, CA
No. of patents: 498

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Number	Title	Issue Date
8183293	Phenyl acetic acid derivatives Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins inv...	05/22/2012
8183259	Heterocyclic compounds and their uses Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psorias...	05/22/2012
8183258	Heterocyclic compounds and their uses Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psorias...	05/22/2012
8183244	Glycine transporter-1 inhibitors The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ...	05/22/2012
8182813	Human C-FMS antigen binding proteins Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-1, reduce monocyte mi...	05/22/2012
8178557	Compounds and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophyl...	05/15/2012
8173810	Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compound...	05/08/2012
8168762	Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 ...	05/01/2012
8168592	CGRP peptide antagonists and conjugates Disclosed is a composition of matter that involves a CGRP peptide antagonist. A pharmaceutical composition is disclosed that comprises the composition of matter and a pharmaceutically acceptable carrier, which can be configured for administration to a patient. Also ...	05/01/2012
8168416	Modified lecithin-cholesterol acyltransferase enzymes The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide. ...	05/01/2012
8168409	Compositions and methods relating to anti-IGF-1 receptor antibodies The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric anti-IGF-1R antibodies that bind human IGF-1R, IGF-1R-binding fragments ...	05/01/2012
8163909	Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compound...	04/24/2012
8163878	Tumor Endothelial Marker 5-α molecules and uses thereof The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM5α polypeptides. The invention fu...	04/24/2012
8163766	Beta-secretase modulators and methods of use The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compound...	04/24/2012
8163742	Di-amino-substituted heterocyclic compounds and methods of use The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various fibrotic and mast cell related diseases such as mastocytosis. The compounds have a ...	04/24/2012
8163284	Methods of treating TSLP-related inflammatory disorders The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP), including antibodies. In particular embodiments, the disclosure provides fully human, humanized and chimeric anti-T...	04/24/2012
8158759	Compositions and methods relating to glucagon receptor antibodies The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies which specifically bind to the human glucagon receptor. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodi...	04/17/2012
8153633	Phthalazine compounds, compositions and methods of use The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer. ...	04/10/2012
8153631	Triazole compounds and uses related thereto The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound has superior HSD1 inhibitory activity, and ...	04/10/2012
8148109	Interferon-like proteins and uses thereof The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides ...	04/03/2012
8143380	Therapeutic peptides The invention relates to compounds that exhibit improved bioefficacy in multidose administration. More specifically, the invention relates to polypeptides or peptides modified to include an antibody Fc region and one or more water soluble polymers. ...	03/27/2012
8138190	Diaza heterocyclic amide compounds and their uses Diaza heterocyclic amide derivatives according to Formula (I) have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R5, R6, R7	03/20/2012
8129331	Specific binding agents of human angiopoietin-2 Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies. ...	03/06/2012
8124724	Peptides and related molecules that modulate nerve growth factor activity The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically ac...	02/28/2012
8106167	Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of these antibodies and methods for neutralizing NGF function, and pa...	01/31/2012
8101612	Phthalazine compounds and methods of use The present invention comprises a new class of compounds useful for the prophylaxis and treatment of p38 kinase mediated diseases and related inflammatory conditions. The compounds have a general Formula II wherein L1	01/24/2012
8101184	Treatment methods using Dkk-1 antibodies The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 ...	01/24/2012
8097620	Diazaquinolones that inhibit prolyl hydroxylase activity Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein. ...	01/17/2012
8093299	Methods of treating bowel disorders The present invention relates to methods for treating bowel disorders using calcimimetics. ...	01/10/2012
8084479	Thiazole compounds and methods of use The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provi...	12/27/2011
8080546	Pyrazolo-pyridinone derivatives and methods of use The present invention comprises a new class of compounds useful for the prophylaxis and treatment of pro-inflammatory cytokine mediated diseases, and in particular, p38 activity mediated inflammation and related conditions. The compounds have a general Formula I...	12/20/2011
8076330	Dipeptidyl peptidase-IV inhibitors The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulat...	12/13/2011
8071372	Tumor endothelial marker 5α molecules and uses thereof The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM5α polypeptides. The invention fu...	12/06/2011
8067562	Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor...	11/29/2011
8063055	Substituted pyridone compounds and methods of use The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The...	11/22/2011
8058445	Substituted pyridinecarboxamides for the treatment of cancer Selected pyridine carboxamide compounds of Formula XI are effective for treatment of diseases and other maladies or conditions involving, cancer and the like. ...	11/15/2011
8058418	Polynucleotides encoding heavy and light chains of antibodies to OPGL Compositions comprising polynucleotides encoding heavy and light chains of antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of making such antibodies are described. ...	11/15/2011
8058398	Modified G-CSF polypeptide The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions containing hybrid molecules. ...	11/15/2011
8053438	Pyrazine compounds as phosphodiesterase 10 inhibitors Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bip...	11/08/2011
8053408	Methods for treating obesity using fibroblast growth factor-like polypeptides The present invention provides methods for reducing body weight in a mammal using Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. ...	11/08/2011

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Assignee: Amgen Inc.