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| Number | Title | Issue Date |
| 5541083 | Method for producing secretable glycosyltransferases and other golgi processing enzymes A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor... | 07/30/1996 |
| 5310660 | Method and a hybrid promoter for controlling exogenous gene transcription A hybrid promoter for controlling exogenous gene transcription is constructed by insertion of a UASG into a GPD portable promoter. The resulting hybrid promoter is placed upstream of an exogenous gene in a hybrid yeast-bacterial plasmid, which ... | 05/10/1994 |
| 5278062 | Proteolytic enzymes This disclosure relates to a novel class of serine proteases isolated from a culture medium of fungus Tritirachium album. The serine proteases disclosed have a high degree of stability in detergent formulations. In addition, this disclosure relates to a proces... | 01/11/1994 |
| 5273882 | Method and kit for performing nucleic acid hybridization assays A method and a kit for the isolation and quantitative detection of a selected target nucleic acid sequence from solution employing two probes. A first probe is complementary to one portion of the target and is covalently attached to a first complexing age... | 12/28/1993 |
| 4977092 | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells Novel yeast cell transformation vectors are manufactured and employed in securing expression of exogenous polypeptides in yeast cells. Vectors include promoter/regulator DNA sequences of yeast glyceraldehyde-3-phosphate dehydrogenase gene origins. In an i... | 12/11/1990 |
| 4966844 | Method for microbial cell killing In processes for recovery of biologically active polypeptides from fermentation cultures of recombinant host organisms, cell death is frequently a prerequisite for isolation processing of the recombinant product outside the fermentation vessel. Disclosed ... | 10/30/1990 |
| 4935350 | Materials and methods for controlling plasmid copy number and stability Methods and constructions for controlling the copy number and for maintaining the stability of a plasmid in yeast cells involving inserting into the plasmid a centromere sequence under the transcriptional control of a regulatable promotor. The promoter is... | 06/19/1990 |
| 4897471 | Consensus human leukocyte interferon Described are rapid and highly efficient procedures for the total synthesis of linear, double stranded DNA sequences in excess of about 200 base pairs in length, which sequences may comprise entire structural genes. Novel sequences are prepared from two o... | 01/30/1990 |
| 4873312 | Method for purifying interferon and composition of matter produced thereby A composition of matter consisting of recombinant human immune interferon having a near-UV circular dichroic spectrum in aqueous solution at neutral pH with positive bands at about 259 nm, 266 nm, 280 nm, and 287 nm, and with shoulders at about 270 nm and... | 10/10/1989 |
| 4751177 | Methods and kits for performing nucleic acid hybridization assays A method for the isolation and quantitative detection of a selected single-stranded target polynucleotide from solution. The target polynucleotide is hybridized in solution to a single-stranded mediator polynucleotide, a probe polynucleotide, and an immob... | 06/14/1988 |
| 4739044 | Method for derivitization of polynucleotides A method for the preparation of a 3' end functionalized polynucleotide is disclosed. An amine-functionalized solid phase support is treated sequentially with an anhydride, then with an ω-hydroxylamine. A polynucleotide is chemically synthesized on the tr... | 04/19/1988 |
| 4699897 | Biologically active peptides structurally related to regions within growth hormones Disclosed are novel synthetic peptides having primary structural homology to a continuous sequence of amino acid residues of human growth hormone in a region spanning positions thirty-two to forty-six ("hGH32-46 ", or "deletion peptide"). In pr... | 10/13/1987 |
| 4695623 | Consensus human leukocyte interferon Described are rapid and highly efficient procedures for the total synthesis of linear, double stranded DNA sequences in excess of about 200 base pairs in length, which sequences may comprise entire structural genes. Novel sequences are prepared from two o... | 09/22/1987 |
| 4689406 | Enhancement of microbial expression of polypeptides Disclosed are novel DNA sequences operative as promoters of microbial transcription of structural genes and comprising synthetic E.coli bacteriophage T5 "early" promoter replica DNA sequences. Disclosed also are novel promoter/operator DNA sequences compr... | 08/25/1987 |
| 4666839 | Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin Disclosed are methods for selective modification of double-stranded DNA sequences facilitating their storage and incorporation into expression vectors. Manufactured partially double-stranded DNA primers are hybridized to complementary regions of single-st... | 05/19/1987 |
| 4652639 | Manufacture and expression of structural genes Described are rapid and highly efficient procedures for the total synthesis of linear, double stranded DNA sequences of up to about 200 base pairs, which sequences may comprise entire structural genes. Illustratively disclosed is the preparation and expre... | 03/24/1987 |
| 4558033 | Potentiation of the effects of insulin by peptides Disclosed are novel methods and materials for developing hypoglycemic effects in mammals, including human. A pentadecapeptide ("deletion peptide") having the sequence, NH2 -Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-Leu-Gln-COOH, is ... | 12/10/1985 |
| 4520103 | Microbial production of indigo Microbial synthesis of indigo dyestuff in indole-free media is disclosed. Indigo production is preferably accomplished by genetic transformation of selected host cells having the capacity to produce and accumulate indole (either as a result of endogenous ... | 05/28/1985 |
| 4504586 | Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1 Murine-derived hybridoma tumor cell lines and monoclonal anti-Colony Stimulating Factor Subclass Number 1 antibody substances produced by these cell lines. Use of said monoclonal antibody substances, alone or in combination, in immunological procedures fo... | 03/12/1985 |
