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Assignee: Amersham Biosciences AB


Location: Uppsala, SE
No. of patents: 44

1    
NumberTitleIssue Date
7008542Method for mixed mode adsorption
Method for the removal of a substance from an aqueous liquid by ion exchange comprising providing a liquid with said substance is present; providing an adsorption matrix which comprises at least two different ligands; contacting the liquid with the matrix under a pe...
03/07/2006
7005071Method of generating metal chelating affinity ligands
The present invention relates to a method of generating at least one polydentate metal chelating affinity ligand, which method comprises the steps of a) providing at least one cyclic scaffold comprising a carbonyl, an adjacent sulphur and a nucleophile;...
02/28/2006
6986992P450 single nucleotide polymorphism biochip analysis
This invention relates to methods and compositions for determining single nucleotide polymorphisms (SNPs) in P450 genes. In preferred embodiments, self extension of interrogation probes is prevented by using novel non self-extension probes and/or methods, thereby im...
01/17/2006
6984733Manufacturing process for porous material
A method for the manufacture of a solid porous separation material based on a polysaccharide, said method comprising the steps of: (a) providing an aqueous solution (I) of a polysaccharide, (b) solidifying the solution, preferably by transforming the solution to a g...
01/10/2006
6969045Rotary valve
The present invention relates to valves with small dead volumes. A valve in accordance with the present invention has a ferrule (7) which receives a plurality of fluid lines (33) which lead to outlets on an end surface (25) of said ferrule (7...
11/29/2005
6936166Endpiece for a chromatography column
A liquid transfer system (100) comprising a net (170) and a net support (160), wherein, the net (170) is integrally joined with the net support (160). The net (170) and the net support (160) are preferably joined by w...
08/30/2005
6921638Hydrogel-based microarray signal amplification methods and devices therefor
Methods and devices for detecting nucleic acid and protein targets on hydrogel microarrays are disclosed. Fluorophores are incorporated into the targets and detected. A linear correlation between target concentration and signal amplitude is maintained through the el...
07/26/2005
6916919Isolation of DNA molecules
The present invention relates to a process for separating nucleic acid molecules, preferably open circular and supercoiled plasmid DNA and RNA molecules from each other, comprising the steps of providing a solution comprising the molecules; adsorbing the molecules t...
07/12/2005
6905595Scalable liquid distribution system for large scale chromatography columns
A uniform fluid distribution system (2) for use with a liquid transfer system (100) for maintaining an interface between liquid phases within a large scale separator system including a cell into which liquid may be introduced as discrete phases at an i...
06/14/2005
D506261Chromatography column locking ring
06/14/2005
6852230Method for the manufacture of compositions containing low concentrations of salts
Method for desalting an aqueous liquid containing a charged substance comprising the steps of: (i) contacting liquid (I) with an ion-exchanger (1) under conditions permitting binding between ion-exchanger and substance, said ion-exchanger comprising a base matrix ca...
02/08/2005
6843427Method and device for producing a coherent layer of even thickness of liquid or melt on a rotating disk
Method and device for continuously producing a coherent layer of a liquid/melt of even thickness by means of centrifugal action along the entire periphery of a rotating disk (13, 113), liquid/melt being supplied to the disk around its entire axis of rotation ...
01/18/2005
6841097Method of producing porous spherical particles
The invention refers to a method of controlling the porosity of porous spherical particles produced from a polysaccharide dissolved in a solvent, in which it can be gelled. The polysaccharide solution is finely divided by mechanical means into spherical droplets whi...
01/11/2005
D500856Chromatography column assembly
01/11/2005
D500555Chromatography column end cap
01/04/2005
6835379Method of producing IgG
A method for producing IgG from plasma for medical applications, comprising at least: (i′) removal of albumin resulting in an IgG fraction, (ii′) purifying IgG from an IgG fraction, which is derived from the IgG fraction obtained in step (i′), by adsorbing IgG...
12/28/2004
6833545Method and device for performing analyses in parallel
The present invention relates to analysis devices having means (3, 5, 7) for producing a plurality of ion beams of samples substantially simultaneously; mass separating means for individually mass separating each ion beam in parallel and detecting means (1...
12/21/2004
6800847Fast variable gain detector system and method of controlling the same
A micro-channel plate (MCP) detector system (30) comprising a MCP detector, a data acquisition unit (20), wherein the detector comprises a first and a second MCP electron multiplier (12, 14), one or more anodes (16) connected to the data ...
10/05/2004
6790613Method of preparing an oligonucleotide array
This invention relates to the improvement of arrays of porous polymer pads on solid supports used in biological assays. The invention involves freeze drying the porous polymer pads to increase pore size. The increased pore size results in an enhanced ability of the ...
09/14/2004
D495060Chromatography column assembly end cap
08/24/2004
6748985Inlet device and its use
An inlet device for a reactor vessel (5) intended for a separation method comprising retaining a substance on a separation medium from a liquid passing through the reactor vessel (5) which contains the separation medium. The device comprises (a) a dist...
06/15/2004
6745133Mass spectral peak identification
The monoisotopic mass peak of an experimentally obtained mass spectrum (262) for a sample molecule is determined using a cross correlation method. A model spectrum (261), having a known monoisotopic peak position, is created based on knowledge of the s...
06/01/2004
6727103Binding assays
In accordance with a first aspect, a binding assay comprises a machine-readable storage medium which supports a molecular receptor (22). In accordance with a second aspect, a support member (50) supports first (22) and second (24) molecul...
04/27/2004
6719899Access valve devices, their use in separation apparatus, and corresponding methods
An access valve suitable for controlling fluid flow into and out of a chromatography column has a central axially movable probe with a head acting as a spool valve in a barrel. Axial movement of the probe adjusts the valve between a fully open condition, in which bo...
04/13/2004
6706188Process and means for down stream processing
A method for recovering a desired component from a sample solution with beads under stabilized fluidized bed conditions is provided. Also provided are support beads for use in downstream processing which comprise a polymer matrix into which glass or silica particles...
03/16/2004
6706486Method for the quantitative release of natural or recombinant proteins, polypeptides or peptides
The present invention relates to a method for the quantitative release of natural or recombinant proteins, polypeptides (thermostable immunoligands) able to bind to the Fc-part of immunoglobulins (antibodies, in particular of the IgG class and primarily becoming bou...
03/16/2004
6706191Chromatographic process utilizing a fluidized bed
A liquid chromatographic process performed at least partly in a fluidised bed contained in a vessel and comprising particle fluidised by an upwardly directed liquid flow, said process comprising (a) a capture step in which one or more compounds of a sample are captu...
03/16/2004
6702943Method for anion-exchange adsorption and anion-exchangers
A method for the removal of a substance carrying a negative charge and being present in an aqueous liquid (I). The method comprises the steps of: (i) contacting the liquid with a matrix carrying a plurality of ligands comprising a positively charged struc...
03/09/2004
6686161Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprisin...
02/03/2004
6685811Method for separation of macromolecules
The invention relates to a method and a system, suitable for automation, for the, preferably preparative, separation of amphoteric macromolecules, e.g. proteins or peptides, wherein said method comprises the steps of: (a) subjecting said mixture of macrom...
02/03/2004
6683302Method and device for electrospray ionization
The present invention relates to electrospray device and a method for heating a liquid in said electrospray device. The device comprising a liquid source (3), a mass analyser (5), and inlet plate (17) with an inlet orifice (19), liquid inlet means such as...
01/27/2004
6664061Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
[2+2] photo-attachable functional groups were incorporated in polyacrylamide based hydrogels and synthetic oligonucleotide probes. The probes were photochemically attached by covalent bonding to the three dimensional surface of a hydrogel....
12/16/2003
6656876Squaric acid activated carrier usable for immobilization of compounds containing amine groups
A storage stable composition comprising a carrier usable for the immobilization of compounds containing an amine group, for instance biomolecules and/or affinity ligands. The carrier has been activated to exhibit a squaric acid derivative linked to the ca...
12/02/2003
6635174Foamed material filled with inner material
A matrix including: a) a polymeric base matrix including macropores (pore system 1) and b) an interior material, possibly porous (pore system 2), retained within the macropores. The matrix is characterized in that there is a continuous free volume between...
10/21/2003
6613884Method for the removal/purification of serum albumins and means for use in the method
A method for removing a serum albumin from a mixture of other compounds by contacting said mixture with a ligand a) having affinity for and enabling selective binding of the serum albumin and b) being attached to a base matrix insoluble in the aqueous med...
09/02/2003
6610208Device for reducing loss of liquid during fraction collection
Spillage of liquid during switching of receptacles in a fraction collector is avoided by introducing a device in the flow path between an inlet tube and a dispensing means. The device includes an expandable chamber that accommodates liquid during the time...
08/26/2003
6610200System and its units
This application discloses liquid chromatographic system including units selected from: a) a block (4) for distributing a liquid flow to a vessel (8), the characteristics being that there are through passing channels (7) comprising a narrow part (7a) and ...
08/26/2003
6602990Process for the production of a porous cross-linked polysaccharide gel and its use as a gel filtration media and in chromatography
A process for the production of a porous cross-linked polysaccharide gel and a gel obtainable by the following steps: a) preparing a solution or dispersion of the polysaccharide; b) adding a bifunctional cross-linking agent having one active site and one ...
08/05/2003
6590096Process for the production of polysaccharide beads
The present invention relates to a method for producing porous polysaccharide beads, comprising: (a) mixing a water-based solution of a polysaccharide under stirring with an essentially water-immiscible first organic phase to form an emulsion which separa...
07/08/2003
6572766Matrices for separation and separation exploiting said matrices
A matrix is disclosed including a core showing a system of micropores and a surface in which the micropore system has openings. The characterizing feature is that the surface is coated with a polymer (I) having such a large molecular weight that it cannot...
06/03/2003
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