Assignee: American National Red Cross

Location: Washington, DC
No. of patents: 32

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Number	Title	Issue Date
7435869	Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glan...	10/14/2008
7393628	Method for enriching adherent monocyte populations The present invention provides methods and apparatus for the rapid and efficient collection and purification of activated monocytes. The methods and apparatus of the present invention provide means for effecting the collection and purification in an aseptic environm...	07/01/2008
7365173	Method for the production of pure virally inactivated butyrylcholinesterase The present invention provides a method for purifying butyrylcholinesterase from various biological fluids. Biological fluids include, e.g., blood, blood fractions, plasma, and bioreactor broths, and other such mixtures containing butyrylcholinesterase. In one embod...	04/29/2008
6518482	Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human F...	02/11/2003
6255554	Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human F...	07/03/2001
6193891	Methods for the selective separation of organic components from biological fluids The present invention pertains to improved methods for the selective separation of organic components from biological fluids. More particularly, the present invention pertains to methods for the selective separation of organic components from biological f...	02/27/2001
6103498	Mutant plasminogen activator-inhibitor type 1 (PAI-1) and uses thereof Mutants of the human PAI-1 protein are described which are inhibitors of neutrophil elastase or are inhibitors of vitronectin (Vn)-dependent cell migration. These mutants preferably comprise one or two amino acid substitutions in the reactive center loop ...	08/15/2000
5922598	Reducing tissue immunogenicity by induction of apoptosis A cell is subjected to apoptosis, a genetically programmed autolysis of the cell. Cells of a specific type, classified by function, maturity, source, etc. can be effectively removed from a mixture of cells in a tissue or cell suspension by their different...	07/13/1999
5880327	Transgenic mammals expressing human coagulation factor VIII A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human F...	03/09/1999
5487971	Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes adenine and a physiologically compatible, aqueous electrolyte so...	01/30/1996
5403596	Factor Xa inhibitor and pharmaceutical compositions containing same A novel anticoagulant/modulator factor isolated from the saliva of the meinal leech Hirudo medicinalis, specifically inhibiting bovine Xa factor but not inhibiting bovine thrombin....	04/04/1995
5330439	Safety device for use in collecting fluid samples A safety device for collecting fluids for laboratory testing is disclosed. More particularly, the invention relates to an apparatus for collecting multiple undiluted blood samples for subsequent laboratory testing wherein the apparatus is provided with a ...	07/19/1994
5248506	Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In o...	09/28/1993
4911703	Mobile, self-contained blood collection system and method Methods and systems for collection of blood components, such as plasma, from donors are provided. One method includes the steps of collecting a unit of whole blood froma donor; forcing the collected blood unit through a plasma separator; accumulating the ...	03/27/1990
4908314	Protein C activator A protein C activator is purified from the venom of the Southern copperhead snake. The resultant enzyme is a very specific and efficient activator of protein C. The high efficiency and specificity enables the sensitive measurement of functional protein C ...	03/13/1990
4622302	Process for inducing membrane fusion under an electric field A device and process for inducing membrane fusion under an electric field. The process comprises the steps of (a) suspending said membranes in an aqueous buffered medium in a manner so that the membranes are without contact with each other; (b) altering s...	11/11/1986
4608255	Biocompatible method for in situ production of functional platelets and product produced thereby lacking immunogenicity The present invention discloses the effect of ultraviolet (UV) radiation on platelet concentrates collected in a plastics container, particularly in a polypropylene bag. Samples irradiated at 310 nm for 30 minutes at a dose of 774 J/M2 show no ...	08/26/1986
4585735	Prolonged storage of red blood cells The present invention discloses a hypotonic suspension medium and a method for prolonged storage of red blood cells at about 4° C. The suspension medium comprises about 80-150 mM glucose, 30-80 mM mannitol, 6-90 mM potassium citrate, 1-5 mM adenine and 1...	04/29/1986
4559298	Cryopreservation of biological materials in a non-frozen or vitreous state A method is provided for the successful cryopreservation of biological materials including whole organs, organ sections, tissues and cells, in a non-frozen (vitreous) state, comprising cooling the biological material to be preserved under pressure in the ...	12/17/1985
4557717	Cup insert for balancing A centrifuge cup insert having an outer container and an inner container disposed therein with a spacer means between the containers to afford a reservoir between the containers capable of holding a liquid, the reservoir communicating with the atmosphere;...	12/10/1985
4447416	Plasma protein concentrates of reduced thrombogenicity and their use in clinical replacement therapy Plasma concentrates of vitamin-K dependent clotting factors of reduced thrombogenic potential useful for clinical replacement therapy in deficiency diseases of these clotting factors are provided. Preferably, concentrates substantially devoid of zymogens ...	05/08/1984
4420398	Filteration method for cell produced antiviral substances This invention affords a filtration method and apparatus for extracting cell produced antiviral substances (CPAS) from a production broth using cross-flow membrane filtration. The broth is perfused into a first filtration cell and caused to cross-flow acr...	12/13/1983
4379085	Heat stabilization of plasma proteins A method for the heat stabilization of a plasma protein such as C1-INA or Factor IX comprising heating the protein in an aqueous medium in the presence of potassium or ammonium citrate in an amount of from in excess of 2.0 M to saturation of the medium. T...	04/05/1983
4264449	Antibody-specific solid phase immunoadsorbent, preparation thereof, and antibody purification therewith An antibody-specific solid phase immunoadsorbent is prepared by adsorptively binding a lipid-containing viral antigen, such as hepatitis B surface antigen, to the surface of a porous glass carrier having an average pore diameter within the range of about ...	04/28/1981
4255788	Phasing detector for continuous flow systems A phasing system is provided for parallel channel continuous flow systems wherein the individual test channels have different flow times although intersample timing is constant. A phasing sample is introduced and its presence is sensed at the output of ea...	03/10/1981
4232004	Antibody-specific solid phase immunoadsorbent, preparation thereof, and antibody purification therewith An antibody-specific solid phase immunoadsorbent is prepared by adsorptively binding a lipid-containing viral antigen, such as hepatitis B surface antigen, to the surface of a porous glass carrier having an average pore diameter within the range of about ...	11/04/1980
4222934	Preparation of albumin using ethanol Methods for the large scale preparation of clinical albumin are disclosed. One method includes dilution of plasma with a NaCl solution containing disodium ethylene dinitrilo tetraacetate and a stabilizer such as sodium caprylate. The resulting solution is...	09/16/1980
4199954	Method of storing physiological material Human cells or tissue in suspension or immersion in physiological solution are stored at a basic storage temperature of about 4° C., and periodically subjected to a higher temperature within the range of from 25°-37° C. for a period of time and at inte...	04/29/1980
4164496	Preparation of albumin using PEG and EDTA Methods for the large scale preparation of clinical albumin are disclosed. One method includes dilution of plasma with a NaCl solution containing disodium ethylene dinitrilo tetraacetate and a stabilizer such as sodium caprylate. The resulting solution is...	08/14/1979
4104266	Method for preparation of antihemophilic factor An improved method for preparation of purified AHF is disclosed. The method includes the cryoprecipitation of plasma, followed by a cold extraction of the cryoprecipitate at low temperature, approximately 0° C, to obtain a cold insoluble fraction. The co...	08/01/1978
4078783	Apparatus for use in a blood collection system Apparatus for use in a blood collection system comprising a combined armrest/writing/worksurface adapted to be supported for adjustable movement on a donor lounge. An upper elongated generally horizontally extending trough supports the arm of a donor duri...	03/14/1978
4057288	Stackable wheeled chair A stackable wheeled chair particularly for use in a mobile blood collection system. Each chair comprises a pair of laterally spaced, generally inverted U-shaped leg means. Each leg means includes front and rear leg members which diverge downwardly from an...	11/08/1977

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Assignee: American National Red Cross