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Patent No. 5508049

Pizza Pie With Concentric Rings of Crust

A pizza mold for forming a plurality of concentric raised ridges of dough (i.e., crust) on the surface of a pizza pie.

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Assignee: American Cyanamid Company


Location: Madison, NJ
No. of patents: 483

1                      
NumberTitleIssue Date
6831079Vasopressin agonist formulation and process
This invention provides novel formulations for vasopressin agonist compounds, or a pharmaceutically acceptable salt thereof, having the general structure: and processes for making them, the formulations comprising from...
12/14/2004
6753417UspA1 and UspA2 antigens of Moraxella catarrhalis
The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7....
06/22/2004
6746677Stable vaccine compositions for parenteral administration, a method for their use, and a process for their preparation
The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solvent; and sal...
06/08/2004
6673540Cell systems having specific interaction of peptide binding pairs
This invention relates to modified host cells which express heterologous fused proteins and methods of screening for test samples having peptide binding activity; wherein the modified host cell comprises: (a) a gene sequence encoding a heterologous fusion...
01/06/2004
6610310Polyanionic polymers as adjuvants for mucosal immunization
Mucosal adjuvants for vaccines contain water-soluble polyanionic polymers which have anionic constitutional units obtained from acids such as acrylic acid, methacrylic acid, maleic acid, fumaric acid, ethylsulphonic acid, vinylsulphuric acid, vinylsulphon...
08/26/2003
6596512Nucleic acid encoding Nematode dopamine transporter and the protein encoded thereby
A nematode dopamine tansporter cDNA has been cloned, sequenced, and expressed, and provides a convenient screening assay for antiparasitics, as well as psychoactive drugs....
07/22/2003
6592873Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
The present invention provides a purified preparation containing a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproducti...
07/15/2003
6552002Sustained-release compositions for parenteral administration
Sustained-release compositions comprising a macrolide compound, a surfactant, a co-solvent, and a solvent. The sustained-release compositions of this invention may be parenterally administered to animals, and are useful for preventing or treating helminth...
04/22/2003
6548496Substituted 3-cyano-[1.7], [1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
This invention provides compounds of formula I having the structure ##STR1## Wherein substitutions at A", Z, n, and X are set forth in the specification....
04/15/2003
6548524Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-଱ converting enzyme (TACE. tumor necrosis factor-଱ converting enzyme) which arc useful for the treatment of ...
04/15/2003
65449842,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
Compounds having the following formula: ##STR1## are useful in treating disease conditions mediated by matrix metalloproteinases and TACE, such as tumor growth, osteoarthritis, rheumatoid arthritis and degenerative cartilage loss....
04/08/2003
6534491Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
This invention provides, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stroinelysins and collagenases) and TNF-଱ converting enzyme (TACE, tumor necrosis factor-댜onverting enzyme) which are useful for the treatment of ...
03/18/2003
6514951Pour-on formulations effective for the control of internal and external parasites of homothermic animals
There are provided non-aqueous pour-on, water-fast formulations effective for the control of internal and external parasitic infections and infestations of homothermic animals such as mammalian quadrupeds. The pour-on formulations of the present invention...
02/04/2003
6498167Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
This invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases and TNF-଱ converting enzyme (TACE, tumor necrosis factor-଱ converting enzyme) of formula (B) as shown herein or a pharmaceutically acceptable sal...
12/24/2002
64893166-(spirocyclopropyl) penicillanic acid 4, 4-dioxides
The 6-(spirocyclopropyl)-penicillanic acid 4,4-dioxides of the general Formula (I): ##STR1## as defined herein above which exhibit beta-lactamase inhibiting activity, use of such compounds in combination with beta-lactam antibiotics for inhibiting be...
12/03/2002
6479537Synergistic ectoparasiticidal methods and compositions
The present invention provides methods for synergistic control of ectoparasitic arthropods with a synergistically effective amount of a combination of the macrocyclic lactone moxidectin and an arylpyrrole compound. Also provided are methods of protecting ...
11/12/2002
646161874 kilodalton outer membrane protein from moraxella catarrhalis
A protein from the M. catarrhalis designated the 74 kD protein is isolated and purified. The 74 kD protein has an amino-terminal amino acid sequence which is conserved among various strains of M. catarrhalis. The protein has a molecular weight of approxim...
10/08/2002
6448262Pesticidal and parasiticidal use of 2-(substituted thio) thiazolo-[4,5-b]pyridine compounds
The present invention relates to the pesticidal and parasiticidal use of 2-(substituted thio)thiazolo[4,5-b]pyridine compounds having the structural formula I ##STR1##...
09/10/2002
6437006Pharmaceutical carrier formulation
This invention provides carrier systems useful in preparing pharmaceutical formulations, the systems comprising, by weight percentage, from about 1% to about 20%, preferably from about 5% to about 12%, of a surfactant component; from about 55% to about 93...
08/20/2002
6432979Method of treating or inhibiting colonic polyps and colorectal cancer
This invention provides a method of treating or inhibiting colonic polyps or treating or inhibiting colorectal cancer in a mammal in need thereof which comprises administering to said mammal an NSAID and an EFGR kinase inhibitor....
08/13/2002
6420358Vasopressin antagonist and diuretic combination
This invention provides methods of increasing urine flow in humans while minimizing the loss of electrolytes or ions, the methods comprising administering to a human in need thereof a combination of N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbo...
07/16/2002
6407217Imidazolinone haptens and antigens and enzyme conjugates prepared therefrom
The present invention provides an imidazolinone hapten having the structural formula ##STR1## Further provided are an antigen and an enzyme conjugate which are prepared from the imidazolinone hapten. The haptens, antigens and enzyme conjugates provid...
06/18/2002
6403581Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives
The invention is a method of treating, inhibiting or controlling a ras-associated disease by inhibiting farnesyl-protein transferase(FPTase) enzyme, treating ras oncogene-dependent tumors, which include cancers of pancreas, breast, lung, colon, epidermis,...
06/11/2002
6399314Methods of detection of amyloidogenic proteins
A method/assay for detecting various aggregated forms of amyloid peptide using amyloid-specific spectroscopic probes, such as Congo red and related analogs, is described. Such an assay could be used to assess the aggregation state of the peptide in the pr...
06/04/2002
6399621N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-଱]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-଱]-pyrimidin-7-yl}p henyl)acetamide, and use of the same as a sedative-hypnotic, anxiolytic, anticonvulsant, and skeletal muscle relaxant agent. Compositions containing N-methyl-N-(3-{3-[2-thieny...
06/04/2002
63957263,6-disubstituted penam sulfone derivatives
Compounds are provided having the following formulae I and II: ##STR1## wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide group;...
05/28/2002
6384051Method of treating or inhibiting colonic polyps
This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula 1 ##STR1## wherein: R1, R2, R3, R4, X, Y, and n are as defined hereinbefore, or a pharmac...
05/07/2002
6372775Reversal of multidrug resistance in human colon carcinoma cells
The present invention describes the use of fumitremorgin A, B and C and a series of diketopiperazines of Formula (I) to resensitize multidrug resistant (MDR) cancer cells to the cytotoxic effects of chemotherapeutic drugs....
04/16/2002
6358980Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
Compounds of the formula: ##STR1## useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection....
03/19/2002
6358883Pesticidal and parasiticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds
The present invention relates to the pesticidal use of 1-aryl-1-(substituted thio, sulfinyl and sulfonyl)-2-nitroethane compounds having the structural formula I ##STR1##...
03/19/2002
6355636Substituted 3-cyano-[1.7],[1.5], and [1.8] naphthyridine inhibitors of tyrosine kinases
This invention provides compounds of formula I having the structure ##STR1## useful as inhibitors of protein tyrosine kinase....
03/12/2002
6355253Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci
Described herein is a method for removing toxic lipooligosaccharide (LOS) from outer membranes of Gram-negative cocci, such as Neisseria meningitidis. LOS-depleted outer membranes and LOS-depleted soluble outer membrane proteins can be prepared, which are...
03/12/2002
6352718Vasopressin antagonist formulation and process
This invention provides novel formulations for N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)-3-chloropheny l]-5-fluoro-2-methyl-benzamide, or a pharmaceutically acceptable salt thereof, and processes for making them, the formulations compris...
03/05/2002
6348643DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
Genomic and cDNA sequences and plant expression vectors encoding for an arabidopsis AHAS small subunit protein are disclosed. The DNA sequences and vectors are used to transform plants to produce transgenic plants which possess elevated levels of toleranc...
02/19/2002
6346535Fungicidal mixtures
The invention relates to a novel fungicidal composition comprising synergistically effective amounts of at least one benzophenone of formula I ##STR1## wherein R1 represents a halogen atom, an optionally substituted alkyl, alkanoyloxy or a...
02/12/2002
6342508N-hydroxy-2-(Alkyl,Aryl or Heteroaryl sulfanyl, sulfinyl or sulfonyl) 3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
Matrix metalloproteinases (MMps) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase...
01/29/2002
6340671Stable compositions for parenteral administration and their use
The invention relates to certain stable microsphere compositions containing a fat, a wax or a mixture thereof; an active ingredient selected from LL-F28249଱-λ compounds, 23-oxo or 23-imino derivatives of LL-F28249଱-λ compounds, milbemycin co...
01/22/2002
6340655Herbicidal emulsifiable concentrate compositions of dinitroaniline and oxyacetamide herbicides
The present invention provides herbicidal emulsifiable concentrate compositions of dinitroaniline herbicides (e.g., pendimethalin) and oxyacetamide herbicides (e.g., fluthiamid). The compositions utilize phosphoric acid as a stabilizing agent to prevent d...
01/22/2002
6340464Adjuvants for vaccines
Vaccine adjuvants comprising a liquid medium contain polymers with anionic constitutive repeating units and hydrophobic constitutive repeating units. Advantageously, the adjuvants are aqueous solutions of partially esterified polyacrylic acids. The novel ...
01/22/2002
6340656Light, extruded compositions containing a light, extrudable, ceramic carrier, methods for their use, and processes for their preparation
The present invention provides light, extruded compositions and methods for their preparation. The light, extruded compositions comprise at least one agricultural compound; a light, extrudable, ceramic carrier; and at least one surface active agent. The p...
01/22/2002
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