Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 6136338 | Oral veterinary composition containing a fluoroquinolone antibacterial agent possessing superior absorption properties and an extended duration of therapeutic antimicrobial blood levels, and a method of treating microbial infection in a ruminant The present invention concerns a formulation for an oral veterinary composition containing a fluoroquinolone antimicrobial agent or a pharmaceutically acceptable salt thereof, and a method of treating a microbial infection in a ruminant. The present veter... | 10/24/2000 |
| 6005072 | Proteins closely related to opioid receptors Isolated DNAs encoding opiorph receptor polypeptides are provided. Recombinant cloning vectors which include these DNA sequences and cells which include these vectors are also provided. Methods for detecting the expression, in a tissue, of mRNA encoding a... | 12/21/1999 |
| 5989903 | Strain for the production of 6-dimethyltetracycline, method for producing the strain and vector for use in the method Recombinant S. aureofaciens cells are provided. These cells comprise: (a) at least one CTC 11 gene; and (b) optionally (i) a CTC 09 gene; (ii) a CTC 03 gene; or (iii)a combination thereof; wherein: the CTC 11 gene is chromosomal, extra-chromosomal, or chromosomal and ... | 11/23/1999 |
| 5973114 | Isolation and characterization of the growth hormone releasing hormone receptor Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the recepto... | 10/26/1999 |
| 5965429 | Strain for the production of 6-demethyltetracycline, method for producing the strain and vector for use in the method Recombinant S. aureofaciens cells are provided. These cells comprise: (a) at least one CTC 11 gene; and (b) optionally (i) a CTC 09 gene; (ii) a CTC 03 gene; or (iii) a combination thereof; wherein: the CTC 11 gene is chromosomal, extra-chromosomal, or chromosomal ... | 10/12/1999 |
| 5932222 | Mutant respiratory syncytial virus (RSV), vaccines containing same and methods of use This invention provides cold adapted mutant RSV, specifically, mutant RSV of subgroup A and B. Nucleic acid molecules encoding the mutant RSV of this invention, and immunogenic polypeptides of these mutant RSV also are provided by this invention. Pharmace... | 08/03/1999 |
| 5928937 | Structure-based designed herbicide resistant products Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbic... | 07/27/1999 |
| 5904693 | Automatic laparoscopic ligation clip applicator A laparoscopic ligation clip applicator for automatically applying a plurality of ligation clips includes a handle assembly having an actuator, an elongated shaft connected to the handle assembly, and an actuating mechanism disposed within the shaft. The ... | 05/18/1999 |
| 5891840 | Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis Novel modified or derivatized recombinant animal somatotropins. Methods for stabilizing recombinant animal somatotropins by modification or deletion of the Cysteine residues utilizing site directed mutagenesis to replace from one to four of the cysteine a... | 04/06/1999 |
| 5888798 | Chondroitinase I and chondroitinase II producing mutants of P. vulgaris Mutant Proteus vulgaris strains are provided that, when grown in the absence of an exogenous chondroitinase I and II inducer, produce P. vulgans chondroitinase I and chondroitinase II proteins. The mutants typically produce chondroitinase I and II protein... | 03/30/1999 |
| 5886175 | 7-(substituted)-8-(substituted)-9-(substitued amino)-6-demethyl-6-deoxytetracyclines The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.... | 03/23/1999 |
| 5866324 | Method of detecting expression of proteins closely related to opioid receptors Isolated DNAs encoding opiorph receptor polypeptides are provided. Recombinant cloning vectors which include these DNA sequences and cells which include these vectors are also provided. Methods for detecting the expression, in a tissue, of mRNA encoding a... | 02/02/1999 |
| 5855883 | Method of disinsertion of vitreous body from neural retina of the eye with Proteus vulgaris chondroitinases I and II Chondroitinase II, a protein having an isoelectric point of approximately 8.4-8.45 and an apparent molecular mass of 112 kDa when electrophoresed in a 4 to 20% gradient acrylamide gel in 25 mM Tris/192 mM glycine buffer at pH 8.5 in the presence of about ... | 01/05/1999 |
| 5853973 | Structure based designed herbicide resistant products Disclosed herein are structure-based modelling methods for the preparation of acetohydroxy acid synthase (AHAS) variants, including those that exhibit selectively increased resistance to herbicides such as imidazoline herbicides and AHAS inhibiting herbic... | 12/29/1998 |
| 5792642 | DNA Sequences and amino acid sequences of class B beta-lactamase enzymes from bacteroides fragilis This invention is directed to the elucidation of DNA sequences encoding Class B beta-lactamase enzymes from Bacteroides fragilis and the amino acid sequences of those enzymes. This invention is also directed to screening methods for identifying antibiotic... | 08/11/1998 |
| 5789604 | Isolation, characterization and structures of new antibiotic components produced by fungal culture 07F275 New antibacterial agents produced by fungal culture 07F275, of which the compound designated 07F275 alpha having the following structure: ##STR1## is representative. Methods for the fermentation, recovery and purification from crude solutions are als... | 08/04/1998 |
| 5770213 | Purified nontypable haemophilus influenzae P5 protein as a vaccine for nontypable haemophilus influenzae infection The present invention relates to P5 outer membrane protein of the non-typable Haemophilus influenzae bacterial strain and antibodies directed to P5 protein. The invention also relates to a method of isolating P5 protein and a vaccine composition for use i... | 06/23/1998 |
| 5741692 | Protein vulgaris chondroitinase II Chondroitinase II, a protein having an isoelectric point of approximately 8.4-8.45 and an apparent molecular mass of 112 kDa when electrophoresed in a 4 to 20% gradient acrylamide gel in 25 mM Tris/192 mM glycine buffer at pH 8.5 in the presence of about ... | 04/21/1998 |
| 5731180 | Imidazolinone resistant AHAS mutants The present invention relates to monocot genes encoding a mutant AHAS enzyme that is specifically resistant to imidazolinone herbicides. Exemplary of these genes are corn DNA sequences which encode an amino acid substitution at position 621 of the wild-ty... | 03/24/1998 |
| 5716617 | Compositions of proteus vulgaris chondroitinase I and chondroitinase II Chondroitinase II, a protein having an isoelectric point of approximately 8.4-8.45 and an apparent molecular mass of 112 kDa when electrophoresed in a 4 to 20% gradient acrylamide gel in 25 mM Tris/192 mM glycine buffer at pH 8.5 in the presence of about ... | 02/10/1998 |
| 5707377 | Ligation clip remover A ligation clip remover removes closed ligation clips from a ligated vessel. The remover includes a handle assembly having a squeezable trigger and a slender barrel assembly connected to the handle assembly. A clip separating mechanism is connected to a d... | 01/13/1998 |
| 5705340 | Methods for screening class B beta-lactamase enzymes from Bacteroides fragilis This invention is directed to the elucidation of DNA sequences encoding Class B beta-lactamase enzymes from Bacteroides fragilis and the amino acid sequences of those enzymes. This invention is also directed to screening methods for identifying antibiotic... | 01/06/1998 |
| 5691196 | Recombinant nucleic acid containing a response element The present invention describes a novel method for screening retinoid X receptor agonists or antagonists, comprising: using a retinoid X receptor expressed by a yeast expression system to screen a compound having a retinoid X receptor agonist or antagonis... | 11/25/1997 |
| 5688451 | Method of forming an absorbable biocompatible suture yarn A process for producing an absorbable biocompatible medical suture yarn includes the step of spin drawing a bioabsorbable polymer to form suture filaments. A spin finish using a non-aqueous based carrier is applied to the filaments during processing, and ... | 11/18/1997 |
| 5679540 | Cloning and identification of a two component signal transducing regulatory system from bacteroides fragilis This invention relates to a purified isolated DNA fragment of Bacteroides fragilis comprising a sequence for an operon containing two genes designated rprX and rprY. These genes encode two signal transducing regulatory proteins designated RprX and RprY. T... | 10/21/1997 |
| 5662897 | Insect viruses, sequences, insecticidal compositions and methods of use Insect viruses capable of killing at least one target insect pest quicker than previously described viruses and DNA sequence conferring that phenotype of faster killing are provided. Further improvement in the speed of killing is obtained when the virus o... | 09/02/1997 |
| 5643757 | High yield production of human apolipoprotein A1 in E. coli. Apolipoprotein A1 is prepared in a T7 RNA polymerase/promoter bacterial expression system that optimizes yield and facilitates subsequent purification of the protein. Apolipoprotein A1 cDNA is cloned into an Escherichia coli plasmid containing a bacteriop... | 07/01/1997 |
| 5643725 | Sequence and analysis of LKP pilin structural genes and the LKP pili operon of nontypable haemophilus influenzae The isolation and cloning of the structural gene, hifA, for the NTHi pili serotype 5 and the serotype 1 LKP operon, DNA molecules capable of hybridizing to the DNA sequences of the Haemophilus influenzae genome related to the serotype 1 LKP operon and DNA... | 07/01/1997 |
| 5641743 | Therapeutic compositions and methods for use of heparin-binding brain mitogens A group of growth factors, designated heparin-binding brain mitogens (HBBMs), is disclosed. The HBBMs are isolated from brain tissue by a sequence of purification steps. The growth factors may be useful in the promotion of angiogenesis, such as in the pro... | 06/24/1997 |
| 5628826 | Method and apparatus for applying coating to surgical needles A method and apparatus for applying a lubricant coating to surgical needles utilizes a belt coating system with two endless belts. The endless belts have confronting running sides and are rotated in opposite directions for feeding the surgical needles the... | 05/13/1997 |
| 5626265 | Dispenser gun for viscous or semi-viscous products A dispenser gun for selectively dispensing controlled quantities of viscous or semi-viscous materials, and in particular liquid pesticides or insecticides, employs a vacuum driven operating system for discharging and reloading the viscous or semi-viscous ... | 05/06/1997 |
| 5620013 | Method for destroying residual lens epithelial cells A method for destroying residual lens epithelial cells in an eye in order to prevent the occurrence of posterior chamber opacification. A solution containing a basement membrane binding agent conjugated to a cytotoxic agent is introduced into the lens cap... | 04/15/1997 |
| 5621050 | Coating for tissue drag reduction This invention relates to materials for medical or veterinary use that possess considerably improved properties with regard to friction. The invention also relates to the production of such materials from existing materials that possess suitable bulk prop... | 04/15/1997 |
| 5612470 | Nucleic acid encoding the growth hormone releasing hormone receptor Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the recepto... | 03/18/1997 |
| 5606022 | Cloning and identification of a two component signal transducing regulatory system from Bacteroides fragilis This invention relates to a purified isolated DNA fragment of Bacteroides fragilis comprising a sequence for an operon containing two genes designated rprX and rprY. These genes encode two signal transducing regulatory proteins designated RprX and RprY. T... | 02/25/1997 |
| 5606040 | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group This disclosure describes disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 complex.... | 02/25/1997 |
| 5599693 | Methods and compositions relating to useful antigens of moraxella catarrhalis The present disclosure relates to selected antigenic proteins obtained from the outer membranes of Moraxella catarrhalis, that have been found by the inventors to have a variety of useful properties. These proteins, termed OMPs ("Outer Membrane Proteins")... | 02/04/1997 |
| 5593671 | Method of attenuating lung capillary leak in a mammal The invention provides a method of attenuating lung capillary leak in a mammal by administering an effective amount of an antifolate, methotrexate.... | 01/14/1997 |
| 5591576 | Sterol Ɗ14 reductase screen A binary assay identifies agents that inhibit sterol Ɗ14 reductase involved in ergosterol biosynthesis. In the primary screen, sterol Ɗ14 reductase inhibition by a test sample is assayed by adding the test sample to a culture of Neurospora crassa having... | 01/07/1997 |
| 5591641 | Nucleic acid encoding the growth hormone releasing hormone receptor Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the recepto... | 01/07/1997 |
