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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 6458840 | Use of valproic acid analog for the treatment and prevention of migraine and affective illness This invention relates to a method for the treatment and prevention of migraine and affective illness by administering a therapeutically effective amount of the valproic acid analog 2-n-propyl-4-hexynoic acid. The compound 2-n-propyl-4-hexynoic acid is an... | 10/01/2002 |
| 6436954 | Benzoquinolizidine and benzoindolizidine derivatives and therapeutic uses thereof Benzo[b]quinolizidine and benzo[f]indolizidine derivatives are provided which are useful for the treatment of Alzheimer's disease, senile dementia or other conditions characterized by memory loss. Pharmaceutical compositions containing these compounds, an... | 08/20/2002 |
| 6300373 | Antiproliferative and neurotrophic molecules Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.... | 10/09/2001 |
| 6274624 | Antiproliferative and neurotrophic molecules Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.... | 08/14/2001 |
| 6268396 | Use of valproic acid analog for the treatment and prevention of migraine and affective illness This invention relates to a method for the treatment and prevention of migraine and affective illness by administering a therapeutically effective amount of the valproic acid analog 2-n-propyl-4-hexynoic acid. The compound 2-n-propyl-4-hexynoic acid is an... | 07/31/2001 |
| 6187593 | Methods for treating a fibrin encapsulated tumor using a fibrin specific monoclonal antibody and compositions used therein The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized germfree animal. The invention also provides methods for the use of such monoclonal antibodies, and polyclonal antibodies derived from an ... | 02/13/2001 |
| 6080384 | Methods for radionuclide-labeling of biomolecules and kits utilizing the same Novel methods for radiolabeling sulfhydryl group-bearing biomolecules, novel compositions useful for radiolabeling sulfhydryl group-bearing biomolecules, kits comprising such novel compositions and methods for imaging mammalian, preferably human, tissue e... | 06/27/2000 |
| 5871737 | Methods for treating a fibrin encapsulated tumor using a fibrin specific monoclonal antibody and compositions used therein The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized germfree animal. The invention also provides methods for the use of such monoclonal antibodies, and polyclonal antibodies derived from an ... | 02/16/1999 |
| 5843690 | Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers An in vitro immunoassay to detect and quantitate soluble crosslinked and non-crosslinked DesAABB fibrin polymers in a sample from a subject. The assay can be used to support a diagnosis of, to evaluate, and to monitor, in a mammalian subject, a thrombotic... | 12/01/1998 |
| 5837540 | Method of producing fibrin-specific antibodies using soluble fibrin polymers as an immunogen The subject invention relates to a method for producing antibodies using as an immunogen a composition comprising soluble crosslinked DesAABB fibrin polymers and soluble non-crosslinked DesAABB fibrin polymers. The invention provides a method for producin... | 11/17/1998 |
| 5723126 | Methods and compositions for therapeutic uses of a fibrin-specific monoclonal antibody The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized germfree animal. The invention also provides methods for the use of such monoclonal antibodies, and polyclonal antibodies derived from an ... | 03/03/1998 |
| 5721122 | Method comprising immunization of antigen-free mice A method of obtaining lymphocytes making a highly specific antibody by immunizing an antigen-free mouse and removing the blood, lymph nodes or spleen from the immunized mouse. Alternatively, a method of making highly specific poly clonal antibodies by imm... | 02/24/1998 |
| 5672746 | Antiproliferative and neurotrophic molecules Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.... | 09/30/1997 |
| 5487892 | Method for treating thrombotic disease using a fibrin specific monoclonal antibody Methods for the use of a fibrin-specific antibody for in vivo inhibition of thrombus formation. Pharmaceutical compositions, as well as kits, for use in such methods are also provided.... | 01/30/1996 |
| 5453359 | Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers An in vitro immunoassay to detect and quantitate soluble crosslinked and non-crosslinked DesAABB fibrin polymers in a sample from a subject. The assay can be used to support a diagnosis of, to evaluate, and to monitor, in a mammalian subject, a thrombotic... | 09/26/1995 |
| 5428635 | Multi-wavelength tunable laser A laser capable of generating polychromatic or white light radiation is realized by employing dispersive and reflecting elements as the ends of a simple laser resonator cavity. The dispersive element either solely or in combination with an intracavity len... | 06/27/1995 |
| 5418805 | Device for pumping the active medium of a white light laser A polychromatic or white light laser arrangement for changing the dimensions of the pumped portions of the active medium is realized by employing an optical divider for dividing the pump radiation into at least two beamlets, and one or more lenses for foc... | 05/23/1995 |
| 5418803 | White light laser technology A laser capable of generating polychromatic or whim light radiation is realized by employing a diffraction grating and reflecting element as the ends of a simple laser resonator cavity. The dispersive element either solely or in combination with an intrac... | 05/23/1995 |
| 5418804 | Controlled spectrum generation laser A controlled spectrum generation laser arrangement achieving greater uniformity in the optical power spectral distribution is realized by employing a matching plate that conforms the boundary interface of the active medium with the shape of the focal surf... | 05/23/1995 |
| 5223410 | Method for production of antibodies utilizing an antigen-free animal The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized antigen free animal. The invention also provides a method for the use of such monoclonal antibodies, and polyclonal antibodies derived fro... | 06/29/1993 |
| 5120834 | Fibrin-specific monoclonal antibody The subject invention relates to a fibrin-specific monoclonal antibody wherein said monoclonal antibody does not crossreact with: (a) fibrinogen, (b) plasmin derived fibrinogen degradation products and (c) plasmin derived fibrin degradation products.... | 06/09/1992 |
| 5091512 | Fibrinogen-specific monoclonal antibody The subject invention relates to a fibrinogen-specific monoclonal antibody wherein said monoclonal antibody: (a) binds to the isolated A chain of fibrinogen, (b) does not prolong the conversion time of fibrinogen to fibrin by thrombin, (c) binds to... | 02/25/1992 |
| 5041379 | Heliothis expression systems The present invention relates to recombinant vector/host systems which can direct the expression of foreign genes under the control of the Heliothis polyhedrin promoter. Using the systems of the present invention, a heterologous gene of interest can be ex... | 08/20/1991 |
| 4870023 | Recombinant baculovirus occlusion bodies in vaccines and biological insecticides The present invention is directed to recombinant baculoviruses which encode fusion polyhedrin proteins capable of forming occlusion bodies containing foreign peptides. The recombinant baculoviruses of the invention are formed by insertion into or replacem... | 09/26/1989 |
| 4661453 | Production of tissue plasminogen activator factor A process for the production of a tissue plasminogen activator obtained from cultured rat prostate adenocarcinoma cells. The techniques described lead to enhanced production of the tissue plasminogen activator for markedly prolonged periods of time. The t... | 04/28/1987 |
