Assignee: Ambrx, Inc.

Location: La Jolla, CA
No. of patents: 39

Number	Title	Issue Date
8178494	Modified human growth hormone formulations with an increased serum half-life Formulations of modified growth hormone polypeptides are provided, including human growth hormone polypeptides with one or more non-naturally encoded amino acids with an increased half-life. ...	05/15/2012
8178108	Methods for expression and purification of recombinant human growth hormone The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encod...	05/15/2012
8153758	Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ...	04/10/2012
8143216	Modified human growth hormone Modified growth hormone polypeptide and uses thereof are provided. ...	03/27/2012
8119603	Modified human interferon polypeptides and their uses Modified human interferon polypeptides and uses thereof are provided. ...	02/21/2012
8114630	Modified interferon beta polypeptides and their uses Modified interferon beta polypeptides and uses thereof are provided. ...	02/14/2012
8097702	Modified human interferon polypeptides with at least one non-naturally encoded amino acid and their uses Modified interferon polypeptides with at least one non-naturally-encoded amino acid and uses thereof are provided. ...	01/17/2012
8093356	Pegylated human interferon polypeptides Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids. ...	01/10/2012
8080391	Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or...	12/20/2011
8071809	Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-contai...	12/06/2011
8053560	Modified human plasma polypeptide or Fc scaffolds and their uses Modified human plasma polypeptides or Fc and uses thereof are provided. ...	11/08/2011
8048988	Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ...	11/01/2011
8022186	Modified human plasma polypeptide or Fc scaffolds and their uses Modified human plasma polypeptides or Fc and uses thereof are provided. ...	09/20/2011
8012931	Modified FGF-21 polypeptides and their uses Modified FGF-21 polypeptides and uses thereof are provided. ...	09/06/2011
8008456	Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Non-natural amino acids and polypeptides with non-natural amino acids are disclosed. Further, polypeptides with non-natural amino acids that are subject to post-translational modification are disclosed. Additionally, methods of making, purifying, and using non-natur...	08/30/2011
8008428	Azide- or acetylene-terminated poly(alkylene oxide, oxyethylated polyol or olefinic Alcohol) The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorp...	08/30/2011
7959926	Methods for expression and purification of recombinant human growth hormone mutants The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encod...	06/14/2011
7947473	Methods for expression and purification of pegylated recombinant human growth hormone containing a non-naturally encoded keto amino acid The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encod...	05/24/2011
7939496	Modified human growth horomone polypeptides and their uses Modified growth hormone polypeptide and uses thereof are provided. ...	05/10/2011
7928163	Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ...	04/19/2011
7919591	Modified human plasma polypeptide or Fc scaffolds and their uses Modified human plasma polypeptides or Fc and uses thereof are provided. ...	04/05/2011
7888533	Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-contai...	02/15/2011
7883866	Compositions of aminoacyl-tRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also...	02/08/2011
7846689	Compositions of aminoacyl-tRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also...	12/07/2010
7858344	Compositions of aminoacyl-tRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also...	12/28/2010
7838265	Compositions of aminoacyl-tRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also...	11/23/2010
7829310	Compositions of aminoacyl-tRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also...	11/09/2010
7820766	Branched acetylene-containing poly(alkylene oxides, oxyethylated polyols or olefinic alcohols) The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorp...	10/26/2010
7816320	Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35 Formulations of modified human growth hormone polypeptides are provided. ...	10/19/2010
7737226	Acetylene group-containing poly(alkylene oxide, oxyethylated polyol or olefinic alcohol) The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorp...	06/15/2010
7736872	Compositions of aminoacyl-TRNA synthetase and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also...	06/15/2010
7696312	Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ...	04/13/2010
7638491	Therapies using non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ...	12/29/2009
7638299	Biosynthetic polypeptides utilizing non-naturally encoded amino acids Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided. ...	12/29/2009
7632924	Antigen-binding polypeptides and their uses Novel antigen-binding polypeptides (ABP) and uses thereof are provided. ...	12/15/2009
7632823	Compositions of tRNA and uses thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also...	12/15/2009
7385028	Derivatization of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ...	06/10/2008
7332571	Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ...	02/19/2008
7230068	Polymer derivatives The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorp...	06/12/2007

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Assignee: Ambrx, Inc.