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| Number | Title | Issue Date |
| 6596745 | Method for treating fibrotic diseases with azolium chroman compounds Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I: ##STR1##... | 07/22/2003 |
| 6596744 | Method for treating fibrotic diseases or other indications IIC Provided is a method of treating or ameliorating a number of indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I or IA, ##STR1## wherein J is oxygen, sulfur, or N--Rd.... | 07/22/2003 |
| 6509480 | Glucose and lipid lowering compounds Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: ##STR1## wherein the dotted line between carbons 5 and 6, the dot... | 01/21/2003 |
| 6506902 | Synthesis of thiazolium compounds Provided is a method of synthesizing a compound of formula I, ##STR1## comprising: (a) reacting a compound of formula II ##STR2## wherein R1 and R2 are independently hydrogen, hydroxy(C1 -C2)alkyl, or (C1 | 01/14/2003 |
| 6458819 | Thiazolium compounds and treatments of disorders associated with protein aging A method and compositions are disclosed for, among other things, in an animal, (i) improving the elasticity or reducing wrinkles of the skin, treating (ii) diabetes or treating or preventing (iii) adverse sequelae of diabetes, (iv) kidney damage, (v) dama... | 10/01/2002 |
| 6380192 | Triazine compounds and method of use therefor The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a substituted 1,2,4-triazine of the formula (I) ##STR1## and the biologically and ... | 04/30/2002 |
| 6326396 | Glucose and lipid lowering compounds Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: ##STR1## wherein the dotted line between carbons 5 and 6, the dot... | 12/04/2001 |
| 6319934 | Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium compounds The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic ... | 11/20/2001 |
| 5932578 | Triazine compounds and methods of use therefor The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a substituted 1,2,4-triazine of the formula (I) ##STR1## and the biologically... | 08/03/1999 |
| 5892000 | Monoclonal antibodies specific for advanced glycosylation endproducts in biological samples The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularl... | 04/06/1999 |
| 5877217 | N-acylaminoalkyl-hydrazinecarboximidamides The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) using compounds of the following formula I ##STR1## wherein alk is a straight or branched chain alkylene group containing from 2 ... | 03/02/1999 |
| 5869527 | 6-(N-carboxymethylamino)caproate, salts thereof and methods of use therefor Compounds useful in the production and analysis of monoclonal antibodies to advanced glycosylation endproducts are 6-(N-carboxymethylamino)caproates of the formula XO2 C--(CH2)5 --NH--CH2 CO2 X (I) whe... | 02/09/1999 |
| 5856511 | Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole and analogs thereof The present invention relates to a practical and facile synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) and analogs thereof. The synthesis utilized a novel hydrazinium salt as an intermediate reaction product which facilitates the isolation ... | 01/05/1999 |
| 5854000 | Methods for measurement predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts Methods are disclosed for measuring the accumulation of advanced glycosylation endproducts (AGEs), which are predicated on the discovery that such AGEs are present in tobacco and its byproducts. More particularly, the methods focus on the observation that... | 12/29/1998 |
| 5853703 | Preventing and reversing the formation of advanced glycosylation endproducts The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylatio... | 12/29/1998 |
| 5850840 | Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts Methods are provided for measuring the accumulation of advanced glycosylation endproducts (AGEs), and for lowering the accumulation of advanced glycosylation endproducts, which are predicated on the discovery that such AGEs and their precedent glycotoxins... | 12/22/1998 |
| 5766590 | Therapeutic methods and pharmaceutical compositions The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularl... | 06/16/1998 |
| 5744318 | Monoclonal antibody for the detection of advanced glycosylation endproducts in biological samples The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularl... | 04/28/1998 |
| 5698563 | Bis-›hydrazones! The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises bis(guanylhydrazone) of the formula ##STR1## capable of inhibiting the format... | 12/16/1997 |
| 5698197 | Monoclonal antibody specific for advanced glycosylation endproducts in biological samples The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularl... | 12/16/1997 |
| 5661139 | Bis-(2-aryl) hydrazones The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a bis-(2-aryl)hydrazone capable of inhibiting the formation of advanced glycosylat... | 08/26/1997 |
| 5656261 | Preventing and reversing advanced glycosylation endproducts The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reve... | 08/12/1997 |
| 5612332 | Di- and triaminoguanidines, and methods of use The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a di- or tri-aminoguanidine capable of inhibiting the formation of adva... | 03/18/1997 |
| 5610076 | Method for detecting hemoglobin advanced glycosylation endproducts The present invention relates to methods for the diagnosis and monitoring of diseases and disorders associate with advanced glycosylation endproducts (AGE) formation, such as diabetes and the ageing process. In particular, the invention is directed to det... | 03/11/1997 |
| 5534540 | Methods of inhibiting the advanced glycosylation of proteins using tetramic and tetronic acids and compositions therefor The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises substituted or unsubstituted tetramic and tetronic acids capable of inhibiting the... | 07/09/1996 |
| 5514676 | Amino-benzoic acids and derivatives, and methods of use The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation ... | 05/07/1996 |
| 5500439 | Aminopyrazoles The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises aminopyrazoles capable of inhibiting the formation of advanced glycosyl... | 03/19/1996 |
| 5476849 | Methods for glycosylation inhibition using amino-benzoic acids and derivatives The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation ... | 12/19/1995 |
| 5468777 | Method and agents for preventing and reversing the staining of teeth The present invention relates to methods and agents for preventing and reversing the staining of teeth caused by the nonenzymatic browning of proteins in the oral cavity. Suitable agents for the inhibition of nonenzymatic browning may be formulated as rin... | 11/21/1995 |
