Bizarre Patents
User-operated amusement apparatus for kicking the user's buttocks
An apparatus including a user-operated and controlled apparatus for self-infliction of repetitive blows to the user's buttocks by a plurality of elongated arms bearing flexible extensions that rotate under the user's control.
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| Number | Title | Issue Date |
| 8067200 | Fusion proteins A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a Targeting Moiety that ... | 11/29/2011 |
| 7638648 | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme. ... | 12/29/2009 |
| 7462699 | BoNT/A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides. ... | 12/09/2008 |
| 7456272 | Neurotoxins with enhanced target specificity Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by proteases in muscle or selectively inactivated by proteases in blood. ... | 11/25/2008 |
| 7452697 | Chromatographic method and system for purifying a botulinum toxin Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium. ... | 11/18/2008 |
| 7445914 | Animal product free media and processes for obtaining a botulinum toxin Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-p... | 11/04/2008 |
| 7439386 | Therapeutic substituted cyclopentanones Compounds are disclosed herein comprising or a pharmaceutically acceptable salt, or a metabolite or a prodrug thereof; wherein a dashed line indicates the presence or absence of a bond; Y, A, an... | 10/21/2008 |
| 7439372 | Therapeutic compounds A compound having a structure is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed. ... | 10/21/2008 |
| 7439371 | Indol kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 10/21/2008 |
| 7438921 | Buttock deformity treatment Methods for treating a buttock deformity or for preventing development of a buttock deformity by local administration of a Clostridial toxin, such as a botulinum neurotoxin, to a buttock deformity or to the vicinity of a buttock deformity. ... | 10/21/2008 |
| 7435746 | 5-thiopiperdinyl prostaglandin E analogs A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y and R are described in detail herein A compound having an ω chain comprising ... | 10/14/2008 |
| 7432388 | Disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity Compounds of the formula where the variables have the values described in the specification are antagonists of RARγretinoid receptors. ... | 10/07/2008 |
| 7429669 | Therapeutic compounds Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed. ... | 09/30/2008 |
| 7429386 | Stretch mark treatment Methods for treating stretch marks by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a stretch mark. ... | 09/30/2008 |
| 7429615 | Cyclohexyl prostaglandin analogs as EP-receptor agonists The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following... | 09/30/2008 |
| 7427685 | Therapeutic substituted cyclopentanes Therapeutic compounds according to one of the structures below are disclosed herein. ... | 09/23/2008 |
| 7427614 | Prostaglandin analogs Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. A, X, J, E, and Z are as described herein. These compounds are useful for treating diseases. ... | 09/23/2008 |
| 7425338 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 09/16/2008 |
| 7422753 | Methods for treating trichotillomania Methods for treating trichotillomania by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 09/09/2008 |
| 7422110 | Titration/compliance pack with increasing doses A titration package and method for enabling compliance with a regime of changing dosage of medication over a period of time includes a backing having an array of receivers with the array including a plurality of columns and a plurality of rows. A plurality of sets o... | 09/09/2008 |
| 7422877 | Activatable recombinant neurotoxins Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. ... | 09/09/2008 |
| 7419675 | Method for treating peritoneal adhesions Methods for treating peritoneal adhesions by local administration of a Clostridial toxin, such as a botulinum toxin, to a patient with a peritoneal adhesion. ... | 09/02/2008 |
| 7419676 | Activatable recombinant neurotoxins Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids. ... | 09/02/2008 |
| 7419994 | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2- thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cyloalkenylmethyl) imidazol-2-ones and related compounds Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in ... | 09/02/2008 |
| 7414054 | 3-(arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 08/19/2008 |
| 7413742 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivativ... | 08/19/2008 |
| 7405240 | Substituted cyclopentanes or cyclopentanones as therapeutic agents The compounds disclosed herein are useful for treating glaucoma, ocular hypertension, and baldness. ... | 07/29/2008 |
| 7399607 | Fluorescence polarization assays for determining clostridial toxin activity The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bul... | 07/15/2008 |
| 7399868 | 4-(Heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B | 07/15/2008 |
| 7396849 | 4-(Condensed cyclicmethyl)-imidazole-2-thiones acting as αadrenergic agonists Compounds of Formula 1 where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or s... | 07/08/2008 |
| 7393925 | Leucine-based motif and Clostridial neurotoxins Modified neurotoxin comprising neurotoxin including structural modification, wherein the structural modification alters the biological persistence, preferably the biological half-life, of the modified neurotoxin relative to an identical neurotoxin without the struct... | 07/01/2008 |
| 7393537 | Botulinum toxin for treatment of obsessive compulsive finger biting disorder Methods for treating obsessions and compulsions by local administration of a Clostridial toxin. The obsessions or compulsions can be eye poking, body rocking, finger biting, counting, checking and related disorders treated by low dose, intramuscular administration o... | 07/01/2008 |
| 7393870 | 3-(heteroarylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 07/01/2008 |
| 7390829 | Alpha-2 adrenergic agonists A compound is disclosed herein comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein R is OH or NH2. Methods, compositions, and medicaments related thereto... | 06/24/2008 |
| 7390496 | Therapeutic treatments for repetitive hand washing Methods for treating a hand washing disorder by local administration of a Clostridial toxin. The local administration can be by intramuscular, transdermal, intradermal or subdermal administration of a low dose of botulinum toxin. ... | 06/24/2008 |
| 7390318 | Needleless microprotrusion elastoplast system A needleless microprotrusion system for infusion of a medicament into a patient includes a plurality of microprotrusions having a length sufficient to penetrate a stratum corneum of the patient. A chemodenervating agent is disposed for delivery by the microprotrusio... | 06/24/2008 |
| 7384648 | Implant device with a retinoid for improved biocompatibility An implant device is provided which incorporates a retinoid for improving the biocompatibility of the device in tissue. The device may be bioerodible for the purpose of systemically or locally releasing a therapeutic agent in tissue or it may be a permanent implant ... | 06/10/2008 |
| 7384918 | Botulinum toxin for treating muscle contracture The invention provides for the use of a botulinum toxin to treat contracture, such as muscle contracture, in patients by transdermal administration of the botulinum toxin. ... | 06/10/2008 |
| 7381700 | Methods for treating pain associated with arthritis A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount of a neurotoxin selected from a group consisting of Botulinum toxin ty... | 06/03/2008 |
| 7378389 | Botulinum toxin neurotoxic component for treating juvenile cerebral palsy The invention provides for the use of a presynaptic neurotoxin (for example a bacterial neurotoxin such as botulinum toxin A) for the manufacture of a medicament for the treatment of cerebral palsy in juvenile patients. The juvenile patients are preferably juveniles... | 05/27/2008 |
