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| Number | Title | Issue Date |
| 6569884 | Conformationally rigid bicyclic and adamantane derivatives useful as 댒-adrenergic blocking agents A compound of formula I ##STR1## in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or ... | 05/27/2003 |
| 6372753 | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists Proliferation of retinal pigment epithelium following surgery or trauma or resulting in ocular diseases associated with choroidal neovascularization, such as age related macular degeneration and histoplasmosis syndrome, is prevented by contacting retinal ... | 04/16/2002 |
| 6319883 | Multi-purpose contact lens care compositions Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than ... | 11/20/2001 |
| 6267768 | Lens protector for intraocular lens inserter An apparatus for inserting an intraocular lens through an incision into an eye includes a tube defining a hollow passage, an injector rod longitudinally moveable within the hollow passage and a force transfer assembly coupled to the injector rod. The inje... | 07/31/2001 |
| 6193683 | Closed loop temperature controlled phacoemulsification system to prevent corneal burns Phacoemulsification apparatus includes a handpiece having a needle and electrical apparatus for ultrasonically vibrating the needle. A power source provides electrical power to the handpiece electrical apparatus and irrigation fluid is provided to the han... | 02/27/2001 |
| 6162249 | IOI for inhibiting cell growth and reducing glare An intraocular lens implantable in an eye includes an optic for placement in the capsular bag of the eye and for directing light toward the retina of the eye. The optic has a central optical axis, an anterior face, an opposing posterior face and a periphe... | 12/19/2000 |
| 6150623 | Back-flip medical footpedal A footpedal suitable for use as an accelerator type pedal or a toe activated pedal includes a frame having a heel portion and a toe portion with the heel and toe portions being disposed at an angle with one another. A wedge having a generally triangular c... | 11/21/2000 |
| 6142999 | Folding device and method for an intraocular lens A folding device for holding and folding an IOL and adapted to allow a surgeon to select between loading the IOL into a removably attached IOL injector and between holding the IOL in a folded state for removal with a separate instrument. The folding devic... | 11/07/2000 |
| 6132436 | Self-regulating phaco sleeve to reduce tissue burn The sleeve apparatus for a phacoemulsification/irrigation and aspiration handpiece having an ultrasonic drive assembly attached to a hollow needle includes a compressible sleeve for establishing an annular passage around the needle and enabling the irriga... | 10/17/2000 |
| 6096902 | Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl de... | 08/01/2000 |
| 6075032 | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists Proliferation of retinal pigment epithelium following surgery or trauma or resulting in ocular diseases associated with choroidal neovascularization, such as age related macular degeneration and histoplasmosis syndrome, is prevented by contacting retinal ... | 06/13/2000 |
| 6073757 | Combined bottle and lens case A container arrangement for contact lenses and solution therefor includes a lens case having receptacles for storing contact lenses in contact lens solution. A bottle is provided for containing the contact lens solution. A bottle is provided for containin... | 06/13/2000 |
| 6071924 | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists Proliferation of retinal pigment epithelium following surgery or trauma is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR) agonist, preferably one with specific activity for retinoic aci... | 06/06/2000 |
| 6063745 | Mutli-purpose contact lens care compositions Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than ... | 05/16/2000 |
| 5990138 | Cyclopentane (ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by a... | 11/23/1999 |
| 5981607 | Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers An eye drop composition for alleviation of dry eye related symptoms in dry eye patients and contact lens wearers includes an emulsion of a higher fatty acid glyceride, polysorbate 80 and an emulsion stabilizing amount of Pemulen.RTM. in water suitable for... | 11/09/1999 |
| 5947974 | Folding device and method for an intraocular lens A folding device for holding and folding an IOL and adapted to allow a surgeon to select between loading the IOL into a removably attached IOL injector and between holding the IOL in a folded state for removal with a separate instrument. The folding devic... | 09/07/1999 |
| 5934500 | Container sealing structure for flexible containers Container closure apparatus including a rigid container having an open end with a top edge along a collapsible container disposed within the rigid container and having an open end. A cap is provided for covering the rigid and flexible container open ends ... | 08/10/1999 |
| 5921989 | Lens protector for intraocular lens inserter An apparatus for inserting an intraocular lens through an incision into an eye includes a tube defining a hollow passage, an injector rod longitudinally moveable within the hollow passage and a force transfer assembly coupled to the injector rod. The inje... | 07/13/1999 |
| 5902523 | IOLs and production methods for same New intraocular lenses (IOLs) and methods for producing IOLs. The present methods include a combination of steps which increase the pull strength between the fixation member of the IOL and the optic of the IOL without requiring sophisticated high frequenc... | 05/11/1999 |
| 5895609 | Intraocular lenses and methods for producing same New intraocular lenses (IOLs) and methods for producing IOLs. The present methods include a combination of steps which increase the pull strength between the fixation member of the IOL and the optic of the IOL without requiring sophisticated high frequenc... | 04/20/1999 |
| 5877211 | EP2 receptor agonists as neuroprotective agents for the eye The invention relates to the use of EP2 receptor agonists as neuroprotective agents. In particular said compounds are represented by the formulae: ##STR1## wherein the broken line attachment to the cyclopentane ring or the omega chain... | 03/02/1999 |
| 5856490 | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification have retinoid-like biological activity.... | 01/05/1999 |
| 5847160 | Acetylenes disubstituted with 2-tetrahydropyranoxy-aryl and aryl of heteroaryl groups having retinoid-like biological activity Compounds of the formula ##STR1## wherein R1 -R5 X, Y, A, B are as defined in the specification, have retinoid-like biological activity.... | 12/08/1998 |
| 5817836 | 2,4-pentadienoic acid derivatives having retinoid-like biological activity Compounds of Formula 1 ##STR1## wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR2## Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 | 10/06/1998 |
| 5814657 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## wherein the variables are defined as in the specification, are capable of lowering introaocular pressure in the eye of a mammal.... | 09/29/1998 |
| 5808124 | O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 09/15/1998 |
| 5808101 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, are capable of lowering intraocular pressure in the eye of a mammal.... | 09/15/1998 |
| 5808083 | Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.... | 09/15/1998 |
| 5798372 | Method for preventing onset of restenosis after angioplasty employing a retinoid A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering a retinoid, such as an RAR-selective retinoid, e.g. the compound of the formula: ##STR1##... | 08/25/1998 |
| 5780647 | 2,4-Pentadienoic acid derivatives having retinoid-like biological activity Compounds of Formula 1 ##STR1## wherein Z is selected from the group consisting of the radicals shown in Formula 2 and in Formula 3, ##STR2## Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 | 07/14/1998 |
| 5776687 | Retinoid induced gene A novel human cDNA, called TIG3 (Tazarotene Induced Gene 3), inducible by RAR-selective retinoids and structurally related to a known tumor suppressor gene. Methods of detecting the TIG3 polynucleotide.... | 07/07/1998 |
| 5773594 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 06/30/1998 |
| 5773654 | 7-(5-substituted cyclopentyl) and (5-substituted cyclopentenyl) heptyl alcohols, heptylamines and heptanoic acid amides, and method of lowering intraocular pressure in the eye of a mammal by administration of these compounds Compounds of the formula ##STR1## where the dotted line represents a bond or the absence of a bond, the wavy lines represent bonds which are either in cis or trans configuration; R1 represents H, or CO-R2 where R2 is ... | 06/30/1998 |
| 5760276 | Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification, have retinoid-like, retinoid antagonist or retinoid inverse agonist-like biological activity.... | 06/02/1998 |
| 5750693 | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity Compounds of the formula ##STR1## where R1 and R2, independently are alkyl groups having 2 to 8 carbons; R3 is hydrogen or lower alkyl; X is S, O or N--R4 where R4 is hydrogen or lower alkyl; Y i... | 05/12/1998 |
| 5747542 | Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 05/05/1998 |
| 5739338 | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid inverse agonist-like biological activity.... | 04/14/1998 |
| 5728846 | Benzo1,2-g!-chrom-3-ene and benzo1,2-g!-thiochrom-3-ene derivatives Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist and/or retinoid inverse-agonist-like biological activity.... | 03/17/1998 |
| 5580392 | Contact lens cleaning compositions with particles of variable hardness and processes of use Compositions and methods for treating a contact lens are disclosed. In one embodiment, the composition comprises an ophthalmically acceptable liquid aqueous medium and a plurality of particles which possess a hardness gradient. The hardness gradient of th... | 12/03/1996 |
