Assignee: Alkermes, Inc.

Location: Cambridge, MA
No. of patents: 32

Number	Title	Issue Date
7612176	Polymer-based sustained release device This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invent...	11/03/2009
7563871	Polymer-based sustained release device This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invent...	07/21/2009
7556798	Highly efficient delivery of a large therapeutic mass aerosol A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less tha...	07/07/2009
7547452	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles Sustained-release microparticle composition. The microparticle composition can be formulated to provide extended release over a period of from about 7 days to about 200 days. The microparticles may be formulated with a biodegradable and biocompatible polymer, and an...	06/16/2009
7524530	Residual solvent extraction method and microparticles produced thereby Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and ...	04/28/2009
7510730	Apparatus and method for preparing microparticles using in-line solvent extraction Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mix...	03/31/2009
7469488	Control of process humidity to produce large, porous particles Spray dried particles having specified aerodynamic characteristics are produced by atomizing a liquid feed and contacting the liquid feed with a drying gas, such as, for example, air or nitrogen. The humidity of the drying gas is controlled to a value, expressed, fo...	12/30/2008
7456254	Polymer-based sustained release device This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invent...	11/25/2008
7300671	Method and apparatus for preparing microparticles using in-line solvent extraction Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mix...	11/27/2007
7279579	Polymorphic forms of naltrexone This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorpora...	10/09/2007
7278425	Inhalation device and method Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber...	10/09/2007
7247319	Preparation of microparticles having improved flowability Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is greater than about 60. The conditioning preferably includes maintain...	07/24/2007
7223440	Residual solvent extraction method and microparticles produced thereby Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and ...	05/29/2007
7164005	Microencapsulation and sustained release of biologically active polypeptides This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invent...	01/16/2007
6630120	Agents to increase the uptake of pharmaceuticals and diagnostic substances into solid tumors Agents, such as bradykinin agonists, increase the transport of pharmaceutical or diagnostic substances that are initially in the bloodstream of a host animal into the interstitial spaces of non-central nervous system solid tumors that may reside in these ...	10/07/2003
6329508	Transferrin receptor reactive chimeric antibodies The present invention pertains to chimeric antibodies that are reactive with transferrin receptors on brain capillary endothelial cells. These antibodies are composed of a variable region, immunologically reactive with the transferrin receptors, that is o...	12/11/2001
6015555	Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates The present invention pertains to a method for delivering a neuropharmaceutical or diagnostic agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neu...	01/18/2000
5833988	Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates The present invention pertains to a method for delivering a neuropharmaceutical or diagnostic agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neu...	11/10/1998
5817343	Method for fabricating polymer-based controlled-release devices A method for forming polymer/drug microparticles comprising the steps of (1) forming a polymer solution/drug mixture comprising a polymer dissolved in an organic solvent and a suspended labile drug; (2) removing the solvent from the polymer solution/drug ...	10/06/1998
5716644	Composition for sustained release of non-aggregated erythropoietin A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible p...	02/10/1998
5686416	Increasing blood-brain barrier permeability with permeabilizer peptides Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously co-administere...	11/11/1997
5674534	Composition for sustained release of non-aggregated erythropoietin A composition, and methods of forming and using said composition, for the sustained release of non-aggregated, biologically active, erythropoietin (EPO). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible p...	10/07/1997
5672683	Transferrin neuropharmaceutical agent fusion protein The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of a ligand-neuropharmaceutical ...	09/30/1997
5667808	Composition for sustained release of human growth hormone The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to ...	09/16/1997
5654010	Composition for sustained release of human growth hormone A composition, and methods of forming and using said composition, for the sustained release of biologically active, stabilized human growth hormone (hGH). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible ...	08/05/1997
5585355	Method for increasing blood-ocular barrier permeability with permeabilizer peptides The permeability of the blood-ocular barrier to therapeutic or diagnostic agents in the bloodstream of a host is increased by administering a permeabilizer peptide, preferably bradykinin or a bradykinin analogue, into the bloodstream of a host. The invent...	12/17/1996
5527527	Transferrin receptor specific antibody-neuropharmaceutical agent conjugates The present invention pertains to a method for delivering a neuropharmaceutical or diagnostic agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neu...	06/18/1996
5506206	Increasing blood-brain barrier permeability with permeabilizer peptides Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in ca...	04/09/1996
5268164	Increasing blood-brain barrier permeability with permeabilizer peptides Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in ca...	12/07/1993
5182107	Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates The present invention pertains to a method for delivering a neuropharmaceutical or diagnostic agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neu...	01/26/1993
5154924	Transferrin receptor specific antibody-neuropharmaceutical agent conjugates The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neuropharmaceutic...	10/13/1992
5112596	Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability The permeability of the blood-brain barrier to endogenous or exogenous neuropharmaceutical or diagnostic agents in an individual's blood stream is increased by administering a bradykinin agonist of blood-brain barrier permeability, such as N-acetyl [Phe	05/12/1992

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Assignee: Alkermes, Inc.