Assignee: Alkermes Controlled Therapeutics Inc.

Location: Cambridge, MA
No. of patents: 32

Number	Title	Issue Date
7371406	Preparation of injectable suspensions having improved injectability Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the ...	05/13/2008
7282216	Biocompatible polymer blends and uses thereof The present invention relates to a novel series of polymers which have been prepared by blending hydrophobic biocompatible, biodegradable polymers or copolymers, such as poly(lactide-co-glycolide), and a biocompatible, amphipathic copolymer having a water absorption...	10/16/2007
6987111	Aripiprazole, olanzapine and haloperidol pamoate salts The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripipraz...	01/17/2006
6861016	Apparatus and method for preparing microparticles Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assemb...	03/01/2005
6830737	Apparatus for preparing microparticles using liquid-liquid extraction Method and apparatus for preparing microparticles using liquid-liquid extraction. A first phase and a second phase are combined to form an emulsion. A portion of the second phase is separated from the emulsion (solvent rich), and the solvent is extracted from the se...	12/14/2004
6824822	Residual solvent extraction method and microparticles produced thereby Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and ...	11/30/2004
6803055	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition includes mic...	10/12/2004
6800663	Crosslinked hydrogel copolymers The present invention relates to crosslinked polymers, synthesized through ring-opening polymerization of ethylenically unsaturated epoxides, in combination with α-hydroxy acids using a hydrophilic macroinitiator, such as poly(ethylene glycol), to form substituted ...	10/05/2004
6713090	Apparatus and method for preparing microparticles Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assemb...	03/30/2004
6544559	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles Sustained-release microparticle composition. The microparticle composition can be formulated to provide multi-phasic release. In one aspect, the composition includes microparticles having more than one rate of release. In another aspect, the composition i...	04/08/2003
6540393	Apparatus for preparing microparticles using in-line solvent extraction Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending...	04/01/2003
6537586	Apparatus and method for preparing microparticles Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mi...	03/25/2003
6514533	Device for the sustained release of aggregation-stabilized, biologically active agent A device for the sustained release in vivo of a water soluble, biologically active agent wherein the agent is susceptible to aggregation comprising a drug delivery device and aggregation-stabilized, biologically active agent wherein the aggregation-stabil...	02/04/2003
6495166	Apparatus and method for preparing microparticles using in-line solvent extraction Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending...	12/17/2002
6495164	Preparation of injectable suspensions having improved injectability Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that const...	12/17/2002
6403114	Preparation of biodegradable, biocompatible microparticles containing a biologically active agent A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. A second phase is prepared. The first and second phases are combined to for...	06/11/2002
6395304	Apparatus and method for preparing microparticles Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mi...	05/28/2002
6379704	Method for preparing microparticles having a selected polymer molecular weight A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecu...	04/30/2002
6368632	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles Method of treating warm blooded animals suffering from psychotic disorders. The method includes administering a pharmaceutically effective amount of sustained-release microparticles that include risperidone, or a pharmaceutically acceptable acid addition ...	04/09/2002
6362308	Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride....	03/26/2002
6331317	Apparatus and method for preparing microparticles Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mi...	12/18/2001
6264987	Method for preparing microparticles having a selected polymer molecular weight A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecu...	07/24/2001
6194006	Preparation of microparticles having a selected release profile An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profi...	02/27/2001
6110503	Preparation of biodegradable, biocompatible microparticles containing a biologically active agent A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. An immiscible second phase is prepared. The first and second phases are com...	08/29/2000
6110921	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles The invention relates to a method of treating psychotic disorders comprising a biodegradable and biocompatible microparticle composition comprising a 1,2-benzazole of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereo...	08/29/2000
5916598	Preparation of biodegradable, biocompatible microparticles containing a biologically active agent A method for preparing biodegradable, biocompatible microparticles. A first phase is prepared that includes a biodegradable, biocompatible polymer, an active agent, and a solvent. An immiscible second phase is prepared. The first and second phases are com...	06/29/1999
5733566	Controlled release of antiparasitic agents in animals A delivery system for providing antiparasitic agents to animals is provided and a method of treating parasitic infections in animals using such delivery systems is described. The delivery system is particularly useful for treatment with avermectins and mi...	03/31/1998
5686092	Growth promoters for animals A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described....	11/11/1997
5656297	Modulated release from biocompatible polymers The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal ca...	08/12/1997
5654008	Preparation of biodegradable microparticles containing a biologically active agent A process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent. A first phase, comprising the active agent and the polymer, and a second phase are pumped through a static mixer into a quenc...	08/05/1997
5650173	Preparation of biodegradable microparticles containing a biologically active agent Disclosed herein is a process for preparing biodegradable microparticles comprising a biodegradable polymeric binder and a biologically active agent, wherein a blend of at least two substantially non-toxic solvents, free of halogenated hydrocarbons, is us...	07/22/1997
5643595	Growth promoters for animals A delivery system for providing growth promoters to food animals is provided and a method of promoting growth in food animals using such delivery systems is described....	07/01/1997

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Assignee: Alkermes Controlled Therapeutics Inc.