Assignee: Albert Einstein College of Medicine of Yeshiva University

Location: Bronx, NY
No. of patents: 231

Number	Title	Issue Date
8173662	Fused pyrimidines as inhibitors of nucleoside phosphorylases and nucleosidases The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MT...	05/08/2012
8173604	Inhibition of Skp2-cyclin a interaction Methods of killing a cancer cell are provided. Also provided are methods of treating a subject having a cancer. Additionally, compounds are provided that comprise a peptide from about 18 to about 100 amino acids or peptidomimetics comprising the sequence of SEQ ID N...	05/08/2012
8129121	Regulation of lipid droplet formation by modulation of FIT1 and FIT2 and uses thereof This invention provides methods of regulating fat storage in tissue by modulating the levels of Fibrate Induced Transcript 1 (FIT1) and/or Fibrate Induced Transcript 2 (FIT2), as well as diagnostic screens for disorders and conditions involving regulation of fat sto...	03/06/2012
8114982	Multi-microRNA methods and compositions Provided are DNAs comprising a polynucleotide that encodes at least a first modified miR-30 precursor and a second modified miR-30 precursor. Also provided are vectors comprising the the DNAs, where the vector can replicate in a host cell. Additionally...	02/14/2012
8101191	Mycobacterial SecA2 mutants Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a m...	01/24/2012
8084041	Use of mycrobacterial vaccines in CD4 or CD8 lymphocyte-deficient mammals Methods of treating a mammal that is deficient in CD4+ and/or CD8+ lymphocytes are provided. The methods comprise inoculating the mammal with an attenuated mycobacterium in the M. tuberculosis complex. In these methods, the mycobacterium...	12/27/2011
8076318	Caged ligands and uses thereof Provided are caged compounds comprising a ligand that specifically reacts with a receptor not naturally present in mammals. The cage is released from the ligand upon illumination of the compound with light. Also provided are cells transfected with a gene of interest...	12/13/2011
8071546	Uses of pegylated albumin The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in a subject, which comprise administering to the subject a therapeutica...	12/06/2011
8071348	Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid residue, wherein the replacement residues together cause a reduction in ca...	12/06/2011
8048635	Measurement of soluble Tweak levels for evaluation of lupus patients Methods of treating patients and evaluating patients for disease stage and/or severity are disclosed. ...	11/01/2011
8030926	Surface coil arrays for simultaneous reception and transmission with a volume coil and uses thereof This invention provides arrays of counter rotating current surface coils for simultaneous reception and transmission with a volume coil for improved signal-to-noise ratio and radio frequency field homogeneity for in particular high-field (4-8 T) imaging of deep body...	10/04/2011
8022043	Ceramide derivatives as modulators of immunity and autoimmunity α-Galactosylceramides and glycosylceramides (“ceramide-like glycolipids”) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the antigen-presenting cells that are capable of efficiently presenting the...	09/20/2011
8003332	Inhibition of membrane fusion proteins Methods of inhibiting viral infection of a eukaryotic cell by a target virus having a class II virus fusion protein are provided. Also provided are methods of screening a test compound for the ability to inhibit infection by a virus having a class II viral fusion pr...	08/23/2011
7998471	Mycobacteria expressing HIV-1 and malaria antigens Provided are recombinant mycobacteria expressing an HIV-1 antigen and a malarial antigen. Also provided are Mycobacterium smegmatis expressing an HIV-1 antigen. Further provided are vaccines capable of inducing an immune response in a mammal against HIV-1 and...	08/16/2011
7939089	Attenuated mycobacteria as vectors for gene delivery to mammalian cells Provided are mycobacteria comprising a recombinant gene operably liked to a mammalian promoter that directs expression of the recombinant gene from a mammalian cell. Also provided are mammalian cells comprising the above mycobacteria. Additionally provided are mycob...	05/10/2011
7902330	Protein kinase inhibitors and methods for identifying same Inhibitors of protein kinase C (PKC)α, PKCδ and PKCζ are provided which are selective for those PKC isotypes. Combinatorial libraries for identifying protein kinases are also provided, as are methods of identifying protein kinases using those libraries. Additiona...	03/08/2011
7888025	Intestinal folate transporter method Provided is an isolated and purified DNA molecule comprising the coding region of a PCFT cDNA. Also provided is a segment of the above DNA molecule, capable of serving as a primer for amplifying at least a portion of the DNA molecule. Additionally provided is a pair...	02/15/2011
7846680	Detection of the nucleolar channel system of human endometrium and uses thereof Methods are disclosed for assaying at the light microscopic level for the presence or absence of nucleolar channel systems (NCSs) in an endometrial tissue sample, as are methods for determining whether or not a postovulatory human endometrium is in a state that is r...	12/07/2010
7846677	Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1 (INI1)/hSNF5 Peptides comprising an Rpt1 domain of an INI1/hSNF5 which inhibit HIV-1 production in a human cell, and vectors encoding those peptides are provided. Also provided are methods of inhibiting HIV-1 production in a cell, or spread of the HIV-1 to another cell, by treat...	12/07/2010
7863499	Model of infantile spasm syndrome Provided are non-human mammals treated with doxorubicin, lipopolysaccharide (LPS), and p-chlorophenylalanine (PCPA), where the mammal exhibits a symptom characteristic of infantile spasms. Also provided are methods of making a non-human mammal exhibit a symptom of i...	01/04/2011
7820401	Collagen VI and cancer Methods of determining whether a cancer is progressing by measuring surface-bound collagen VIα3 are provided. Also provided are methods of identifying hyperplasia in a tissue by measuring surface-bound collagen VIα3. Additionally, methods of identifying carcinoma ...	10/26/2010
7816384	Method for treating a demyelinating condition Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca2+-channel blocker effective to treat the demyelinating condition. In other ...	10/19/2010
7795394	Saitohin gene and uses of same The present invention provides an isolated nucleic acid sequence encoding saitohin (STH), an isolated nucleic acid sequence that hybridizes to said sequence, and a purified protein encoded by said nucleic acid sequences. The present invention also provides a purifie...	09/14/2010
7777025	Transition state analog inhibitors of ricin A-chain Improved transition state analog inhibitors of ricin toxin-A are provided. Methods of using those inhibitors to inhibit ricin toxin-A and to prevent the toxic effects of ricin toxin-A in a mammal are also provided. ...	08/17/2010
7772380	Ceramide derivatives as modulators of immunity and autoimmunity α-Galactosylceramides and glycosylceramides (“ceramide-like glycolipids”) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the antigen-presenting cells that are capable of efficiently presenting the...	08/10/2010
7759459	Fluorescent assays for protein kinases This invention provides fluorescently-labeled peptide substrates for protein kinases; methods using the substrates for identifying compounds that inhibit protein kinases, for determining if particular protein kinases are active in cells, for diagnosing diseases, and...	07/20/2010
7759118	Proliferation of hepatocyte precursors A composition which comprises an animal cell population which contains immature animal cells. The immature animal cells are characterized by expression of alpha-fetoprotein or lack of essential expression of alpha-fetoprotein and albumin, and at least a portion of s...	07/20/2010
7758874	Attenuated vaccines Non-naturally occurring mycobacteria in the Mycobacterium tuberculosis complex are provided. These mycobacteria have a deletion of an RD1 region or a region controlling production of a vitamin, and exhibit attenuated virulence in a mammal when compared to the...	07/20/2010
7745494	Vitamin K for prevention and treatment of skin rash secondary to anti-EGFR therapy The invention provides methods and compositions for treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (EGFR) therapy, where the method comprises applying a vitamin K analog or a phosphatase inhibitor to the skin. ...	06/29/2010
7745163	Method for identifying acetyltransferase substrates The present invention is directed to a method of identifying an acetyltransferase substrate in a sample that includes the steps of: (a) contacting the sample with (i) a reagent comprising a thiol-containing compound, a halo-acetyl-CoA or a halo-acetyl-pantetheine, a...	06/29/2010
7741295	Sir2 products and activities A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of S...	06/22/2010
7736911	Activity-based probes for protein tyrosine phosphatases Provided are compounds capable of covalently binding to a protein tyrosine phosphatase (PTP). The compounds comprise Formula A: Also provided are compositions comprising one of the above compounds covalently bound to a member...	06/15/2010
7709613	Rhenium-188 and rhenium-186 for treatment of tumors expressing a Na/I symporter This invention provides methods of using Rhenium radioisotopes to detect and treat tumors that express a Na+/I− symporter. The invention also provides compositions and methods of making compositions comprising Rhenium radioisotopes for detect...	05/04/2010
7705016	Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus, or stimulating efferent fibers in the hepatic branch ...	04/27/2010
7700759	Aptamer constructs Provided are RNA oligonucleotides having an aptamer flanked by two self-cleaving ribozymes. Vectors encoding the oligonucleotides, and cells transfected with these vectors are also provided. Additionally, methods of inhibiting replication of a virus in a cell, metho...	04/20/2010
7678888	Stable oxidation resistant powdered hemoglobin, methods of preparing same, and uses thereof The present invention provides oxygenated hemoglobins in powdered form and methods of preparing a powdered form of a protein, such as hemoglobin, which comprise (a) mixing a solution of the protein with inulin, and optimally with a reducing sugar such as glucose or ...	03/16/2010
7651689	Methods of applying ionization radiation for therapy of infections This invention provides methods for treating infections in a subject which comprise administering to the subject an amount of a radiolabeled antibody effective to treat the infection, wherein the antibody specifically binds to the agent causing the infection. The in...	01/26/2010
7609060	Non iterative shimming in magnetic resonance imaging in the presence of high LIPID levels For the brain, a variety of automated non-iterative shimming methods using phase evolution derived B0 maps have been reported. These methods assume that there is only a single chemical species contributing to the image. Although true in the brain, lipid c...	10/27/2009
7553839	5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MT...	06/30/2009
7521174	Universal red blood cells, methods of preparing same, and uses thereof The present invention is directed to pegylated red blood cells comprising a polyethylene glycol (PEG) attached to a thiolated amino group on a membrane protein, and to compositions comprising the pegylated red blood cells. The invention also provides methods of prep...	04/21/2009

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Assignee: Albert Einstein College of Medicine of Yeshiva University