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| Number | Title | Issue Date |
| 5441968 | Therapeutically active fluoro substituted benzimidazoles The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH2 OCOOR1, wherein R1 is a straight or branched alkyl containing 1-6 c... | 08/15/1995 |
| 5270056 | Particle having a dyed coke indicator and a pharmaceutical coating for parenteral administration of the pharmaceutical A particle containing a liquid-soluble active substance for release outside a human or animal body, said particle comprising a core with a coating thereon, said coating comprising a liquid soluble active substance, is characterized in that the core has an... | 12/14/1993 |
| 5246714 | Drug preparation Controlled release preparation containing a number of insoluble beads applied with one or more pharmaceutically active compounds, a method for the production thereof and the use in a treatment where a controlled release of a pharmaceutically active compou... | 09/21/1993 |
| 5215974 | Certain pyridyl[(methylthio- or methyl sulfinyl)-2 benzimidazol-2-yl]N-methyl phosphonates useful for treating gastric-acid secretion related diseases Novel compounds of the formula ##STR1## pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine for treating gastric acid related diseases such as gastritis, gastric ulcer, duodenal ulcer a... | 06/01/1993 |
| 5149523 | Polystyrenesulfonate-drug complex and solid dosage forms thereof Almokalant (p-INN), 4-[3-]ethyl[3-(propylsulfinyl)propyl]amino[-2-hydroxypropoxy]-benzonitrile , having the formula ##STR1## is a member of a group of compounds useful in the treatment of cardiac arrhythmias. Enhanced stability, palatability, and... | 09/22/1992 |
| 5106862 | Derivatives of benzimidazoles active as anti-ulcer agents Novel compounds of the general formula I ##STR1## processes for its preparation, pharmaceutical compositions containing such compounds as the active ingredient and the use of the compounds in medicine.... | 04/21/1992 |
| 5093342 | Use of omeprazole as an antimicrobial agent Use of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-sulfinyl]-1H-benz imidazole or a pharmaceutically acceptable salt thereof in the treatment of infectious diseases, especially such caused by Campylobacter pylori.... | 03/03/1992 |
| 5081154 | Metoprolol succinate The present invention relates to metoprolol succinate, a new therapeutically active compound, and pharmaceutical preparations comprising this new compound.... | 01/14/1992 |
| 5075323 | Compounds including omeprazole in the treatment of glaucoma A method for the treatment of diseases related to an increased intraocular pressure in the eye comprising administration to a patient suffering therefrom an amount of a compound of the formula I ##STR1## or a pharmaceutically acceptable salt thereof.... | 12/24/1991 |
| 5068272 | Novel polystyrenesulfonate, useful against cardiac arrhythmias A salt of 4-[3-[3-[ethyl-[3-(propylsulfinyl)propyl]amino]-2-hydroxyproproxy]-benzoni trile having the formula I ##STR1## with polystyrenesulponic acid, which is useful for the treatment of cardiac arrhythmia, process for the preparation of said s... | 11/26/1991 |
| 5055490 | Stereoisomers of benzonitrile derivatives, useful as cardiac arrhythmiac agents 4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzo nitrile, 4-[3-[ethyl[3-((S*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzo nitrile, 4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzo nitrile, 4-[... | 10/08/1991 |
| 5049674 | Therapeutically active fluoro substituted benzimidazoles The novel compounds of the formulas I and I' ##STR1## wherein F is in 5 or 6 position and ##STR2## wherein in both formulas R is the group --CH2 OCOOR1, wherein R1 is a straight or branched alkyl containing 1-6 c... | 09/17/1991 |
| 5039808 | Therapeutically active cyclopropyl substituted compound The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimid azole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and th... | 08/13/1991 |
| 5019584 | Therapeutically active chloro substituted benzimidazole 5-Chloro-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as an intermediate, pharmaceutical compositions containing such compound as active ingredient, and the use of the compound in me... | 05/28/1991 |
| 5008278 | Therapeutically active compound and a process for its preparation The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl) methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and the us... | 04/16/1991 |
| 5001161 | Pharmaceutical composition comprising metroprolol succinate The present invention relates to metoprolol succinate, a new therapeutically active compound, and pharmaceutical preparations comprising this new compound.... | 03/19/1991 |
| 4957745 | Pharmaceutical preparation Controlled release preparation containing a number of beads comprising a salt of metoprolo as the main soluble component, a method for the production thereof and the use in the treatment of cardiovascular disorders.... | 09/18/1990 |
| 4942040 | Pharmaceutical preparation and a process for its preparation Preparation giving a controlled and extended release of both a dihydropyridine, e.g. felodipine and a ଲ-adrenoreceptor antagonist, namely metoprolol as well as a method for the manufacture of the new preparation.... | 07/17/1990 |
| 4927640 | Controlled release beads having glass or silicon dioxide core Controlled release preparation containing a number of insoluble beads applied with one or more pharmaceutically active compounds, a method for the production thereof and the use in a treatment where a controlled release of a pharmaceutically active compou... | 05/22/1990 |
| 4853230 | Pharmaceutical formulations of acid labile substances for oral use Pharmaceutical preparation containing an acid labile compound together with an alkaline reacting compound or an alkaline salt of an acid labile compound optionally together with an alkaline compound as the core material, one or more subcoating layers comp... | 08/01/1989 |
| 4803081 | New pharmaceutical preparations with extended release An extended release perparation of an active compound with very low solubility containing the active compound dissolved or dispersed in a semi-solid or liquid non-ionic solubilizer and whereby the amount by weight of the solubilizer is at least equal to t... | 02/07/1989 |
| 4777293 | Method for the synthesis of pharmacologically active compounds and intermediates for such synthesis A process for the preparation of an aryloxypropanolamine of the formula wherein Ar is a carbocyclic or heterocyclic aromatic group and R is an alkyl or substituted alkyl group having 1 to 6 carbon atoms, characterized in subjecting a compound of the formula ... | 10/11/1988 |
| 4772686 | Enzyme inhibition Peptides wherein an amide bond is replaced by nonhydrolyzable isosteric linkage are disclosed as thrombogenic inhibitors.... | 09/20/1988 |
| 4725691 | 2-[8-quinolinyl]-sulphinyl-1H-benzimidazole Novel compounds of the formula IIIa ##STR1## wherein R1a, R2a, R3a and R4a are the same or different and are hydrogen, an alkyl, alkoxy optionally completely or predominantly substituted by fluorine or chlo... | 02/16/1988 |
| 4713445 | Renin inhibitors and treatments using them Renin-inhibiting analogues of formula ##STR1## where X and W are terminal groups optionally with further amino acyl residues; D, E, B and Z (of which any one or except with `reduced` analogues any two may be absent) are aromatic, lipophilic or in the... | 12/15/1987 |
| 4695272 | Drug release device A drug release device for inclusion in a parenteral drug delivery system, said device comprising a chamber having an inlet for a liquid administerable to a patient by a parenteral route, a drug dissolution space within said chamber, through which said liq... | 09/22/1987 |
| 4689331 | Substituted 2-pyridinyl benzimidazoles, and their use for inhibiting gastric acid secretion Novel compounds of the formula I ##STR1## and its salts; process for the preparation thereof, pharmaceutical compositions containing such compounds and their use in medicine to affect gastric acid secretion and provide gastrointestinal cytoprotection... | 08/25/1987 |
| 4636499 | Sulphenamides Novel compounds of the formula IIIa ##STR1## wherein R1a, R2a, R3a and R4a are the same or different and are hydrogen, an alkyl, alkoxy optionally completely or predominantly substituted by fluorine or chlo... | 01/13/1987 |
| 4636501 | Para-substituted 3-phenoxy-1-carbonylamino-alkylamino-propanol compounds, beta receptor blocking compositions and use Compounds of the formula ##STR1## having beta receptor blocking properties, are disclosed.... | 01/13/1987 |
| 4620008 | Processes for the preparation of omeprazole and intermediates therefore Novel compounds of the formula ##STR1## wherein R is H or CH3, a process for their preparation, and their use as intermediates in the preparation of pharmaceutically useful compounds, e.g. substituted benzimidazoles containing a pyridine r... | 10/28/1986 |
| 4544750 | Certain pyridyl-N-oxide intermediates for the preparation of omeprazole Novel compounds of the formula ##STR1## wherein R is H or CH3, a process for their preparation, and their use as intermediates in the preparation of pharmaceutically useful compounds, e.g. substituted benzimidazoles containing a pyridine r... | 10/01/1985 |
| 4508905 | Substituted 2-(-benzimidazolyl)pyridines The present invention relates to novel compounds of the formula ##STR1## wherein R1 and R2 are the same or different and are each hydrogen, alkyl, halogen, carbomethoxy, carbethoxy, alkoxy, or alkanoyl, R6 is hydrogen... | 04/02/1985 |
| 4465667 | Process for the preparation of gastric acid neutralizing agents, gastric acid neutralizing agents, and a method for treating hyperacidity and disorders related thereto The present invention relates to gastric acid neutralizing compositions comprising dried aluminum hydroxide in suspension form, whereby the composition as suspension stabilizing and suspension forming agent comprises a hydrogenated, hydrolyzed glucose pol... | 08/14/1984 |
| 4341759 | Granule having controlled release properties A method of preparing a preparation made up by bodies comprising an active component in decreasing concentration towards the surface of the bodies. The method comprises coating a particle with a composition comprising the active component in a continuous ... | 07/27/1982 |
| 4337257 | Gastric acid secretion inhibiting substituted 2-(2-benzimidazolyl)-pyridines, their preparation, pharmaceutical preparations containing same, and method for inhibiting gastric acid secretion The present invention relates to novel compounds of the formula ##STR1## wherein R1 and R2 are the same or different and are each hydrogen, alkyl, halogen, carbomethoxy, carbethoxy, alkoxy, or alkanoyl, R6 is hydrogen... | 06/29/1982 |
| 4289795 | Method for preparing preparations having controlled release of an active component A method of preparing a preparation made up by bodies comprising an active component in decreasing concentration towards the surface of the bodies. The method comprises coating a particle with a composition comprising the active component in a continuous ... | 09/15/1981 |
| 4264611 | 2,6-Dimethyl-4-2,3-disubstituted phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid-3,5-asymmetric diesters having hypotensive properties, as well as method for treating hypertensive conditions and pharmaceutical preparations containing same The present invention relates to new compounds having antihypertensive effect, which compounds are of the formula I, ##STR1## wherein R1 is selected from the group consisting of --CH3, --C2 H5, --CH2 | 04/28/1981 |
| 4263325 | ଲ-Receptor blocking compounds and treatment of cardiovascular disorders therewith Amines of the formula I ##STR1## method of preparing the same and pharmaceutical compositions and method for treating cardiovascular disorders by blocking the ଲ-receptors of the heart in combination with a peripheral vasodilating activity.... | 04/21/1981 |
| 4263323 | ଲ-Receptor blocking compounds and treatment of cardiovascular disorders therewith Amines of the formula I ##STR1## method of preparing the same and pharmaceutical compositions and method for treating cardiovascular disorders by blocking the ଲ-receptors of the heart in combination with a peripheral vasodilating activity.... | 04/21/1981 |
| 4261971 | Pharmaceutically preparation comprising a cardiac glycoside in combination with a polymer A solid pharmaceutical preparation for administration in dosage unit form comprising a therapeutically effective cardiac glycoside, whereby each dosage unit is to comprise a plurality of bodies, each of said bodies having a pharmaceutically inert core and... | 04/14/1981 |
