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| Number | Title | Issue Date |
| 5908833 | Colon or ileum-specific steroid derivatives Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formula GCS1 --O--Sugar1 for colon- or ileum-specific delivery of the GCS to inflamed bowel mucosa, as well as processes for their prepa... | 06/01/1999 |
| 5686428 | Pharmaceutical composition Combinations of 3'-azido-3'deoxythymidine and phsphonoformate have been found to produce a synergistic inhibitory effect against human immunodeficiency virus (HIV).... | 11/11/1997 |
| 5616483 | Genomic DNA sequences encoding human BSSL/CEL The present invention relates to a DNA molecule containing intron sequences and encoding a human protein which is, depending on the site of action, called Bile Salt-Stimulated Lipase (BSSL) or Carboxyl Ester Lipase (CEL). The DNA molecule is advantageousl... | 04/01/1997 |
| 5614514 | Steroid esters Compounds of the general formula (I), ##STR1## in which formula the 1,2-position is saturated or is a double bond, R1 is hydrogen or a straight or branched hydrocarbon chain, R2 is hydrogen or a straight or branched hydrocarbon ... | 03/25/1997 |
| 5602099 | δ opioid receptor antagonists The invention concerns compounds of the formula 1 ##STR1## and pharmaceutical compositions containing the compounds as active ingredients. The peptides of the invention are δ opioid receptor antagonists and are useful as analgesics and immunosuppres... | 02/11/1997 |
| 5602253 | Peptides derivatives The invention concerns the compound of the formula: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing serine protease inhibitors. The invention further concerns an improved method f... | 02/11/1997 |
| 5599794 | Synergistic combination of a substance with gastric acid secretion inhibiting effect and an acid degradable antibiotic The invention consists of a combination of a substance that increases the intragastric pH and an acid degradable antibacterial compound. By this combined product regimen it will be possible to obtain maximal local antibacterial effect of acid degradable a... | 02/04/1997 |
| 5591889 | Method for the synthesis of trisodium phosphonoformate hexahydrate The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50° C., adding triethyl phos... | 01/07/1997 |
| 5585378 | Composition containing an oxoindole compound The present invention relates to an oxindole compound having the formula 5-cyclohexyl-1,3-dihydro-1-[2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-2H-in dol-2-one for the prevention or treatment of cognitive dysfunctions.... | 12/17/1996 |
| 5576296 | Galanin antagonist A galanin antagonist which is a galanin receptor ligand is described. New peptides, Galanin (1-12)-Pro-Substance P(5-11), Galanin (1-12)-Pro-Bradykinin(2-9), Galanin (1-12)-Pro-Pro-Pro- (Leu5 -Enkephalin (5-1), Galanin (1-12)-Pro-Lys(&3xb5... | 11/19/1996 |
| 5562923 | Process for conditioning of water-soluble substances A process for providing water-soluble micronized pharmaceutically acceptable inhalable substances, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation of the pharmaceutically acceptable substances. T... | 10/08/1996 |
| 5556964 | Process for the manufacture of budesonide The present invention relates to a novel process for the manufacture of (22 R,S)-16, 17-butylidenedioxy-11ଲ, 21-dihydroxypregna-1,4-diene-3,20 dione (I) by reacting 11ଲ, 16, 17 21-tetrahydroxypregna-1,4-diene (II) w... | 09/17/1996 |
| 5534644 | Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, char... | 07/09/1996 |
| 5523475 | New compounds The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I ##STR1## wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are t... | 06/04/1996 |
| 5500425 | Chroman derivatives and a method of treating 5-HT mediated disorders Compounds of the formula I ##STR1## processes for their preparation, pharmaceutical preparations, use of and method of treatment of disorders in CNS by using compounds of formula I.... | 03/19/1996 |
| 5498724 | Pyrazoleamidine compounds A process for the production of guanidino protected ω-aminoalkyl guanidines comprising reacting a diamine selectively at one amino group with an alkoxycarbonyl or aralkoxycarbonyl protected electrophilic guanylation reagent. The process of the invention ... | 03/12/1996 |
| 5484286 | Method for the preparation of implants made of titanium or alloys thereof The invention relates to a method for treating the surface of surgical implants made of titanium or a titanium alloy, for instance dental implants, before implantation in bone tissue. The method results in a roughened exterior implant surface and at the s... | 01/16/1996 |
| 5468876 | Intermediates for the stereoconservative synthesis of 1-substituted (S)-and (R)-2-aminomethylpyrrolidines Disclosed are (R)- and (S)-isomers of the compounds of the Formulas II and III with at least 95% optical purity ##STR1## wherein R1 and R2 are the same or different and represent a hydrogen atom, a lower alkyl, lower alkenyl or ... | 11/21/1995 |
| 5455230 | Delta opioid receptor antagonists and their use as analgesic agents Compounds of the formula I as well as a process for their preparation, their pharmaceutical preparations and their use H--Tyr--Tic--X (I) wherein X is --Phe--OH, --Phe--NH2, --Phe--Phe--OH, --Phe--Phe--NH2... | 10/03/1995 |
| 5441976 | Pharmacological use of certain cystine derivatives A pharmaceutical preparation and method for the treatment of diseases due to defects in the immune system using cystine derivatives.... | 08/15/1995 |
| 5439917 | Active compounds Therapeutically active compounds of the formula: ##STR1## wherein the variables are defined in the specification are provided.... | 08/08/1995 |
| 5434304 | Process for preparing formoterol and related compounds The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to cer... | 07/18/1995 |
| 5430042 | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use The novel compounds of the formula I ##STR1## and physiologically acceptable salts thereof, wherein R1 and R2, which are different is each H alkyl containing 1-4 carbon atoms or --C(O)--R5 ; wherein R5 is a... | 07/04/1995 |
| 5419918 | Method for the manufacture of a controlled release solid unit dosage form A method for the manufacture of oral controlled release dosage units containing hydroxypropyl methylcellulose wherein the aqueous granulation is performed in the presence of one or more solutes, which inhibit gel formation during the granulation but allow... | 05/30/1995 |
| 5420151 | Chroman derivatives 3-amino-5-carbamoylchromans and 8-fluoro-3-amino-5-carbamoylchromans, as well as enantiomers and salts thereof, are disclosed. Pharmaceutical compositions containing the compounds as active ingredients are also disclosed. The compounds are useful in the t... | 05/30/1995 |
| 5399572 | Chlormethiazole in the treatment of neurodegeneration A thiazole of the following formula is disclosed ##STR1## for the treatment of neurodegeneration involving loss of neuronal structure.... | 03/21/1995 |
| 5395323 | Dissolution system The invention provides a device for mixing a pharmaceutical from a solid supply into a parenterally acceptable liquid flowing through a set for parenteral administration of the liquid to a patient, said device comprising a first compartment defining a mix... | 03/07/1995 |
| 5385904 | Organic salts of N,N'-diacetyl cystine New crystalline organic salts of N,N'-diacetyl cystine with immunomodulating effect, processes for their preparation, pharmaceutical compositions containing them and methods of their pharmacological use.... | 01/31/1995 |
| 5386032 | Method of synthesis of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl-1H-ben zimidazole (omeprazole) The present invention relates to an improved method for the synthesis of omeprazole, comprising the steps of reacting 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-1H-benzimida zole with m-chloroperoxybenzoic acid in a methylene chloride so... | 01/31/1995 |
| 5385921 | Pharmaceutical formulations New pharmaceutical formulations comprising 5-(2-chloro-1-hydroxyethyl)-4-methylthiazole or optical isomers or a pharmaceutically acceptable salt or solvate thereof.... | 01/31/1995 |
| 5380648 | Method for the diagnosis of virulent bacteria Induction of virulence related proteins in virulent pathogenic E. coli and Shigella by growing such bacteria in the presence of Congo Red as induction triggering factor, and the application of the induction for purposes of diagnosing virulent pathogens an... | 01/10/1995 |
| 5376687 | Bicyclic amino-substituted compounds A compound of formula (I), wherein X is O, CH2, S, SO or SO2 ; R is F or Cl; R1 is H, C1 -C6 alkyl or C2 -C6 alkenyl; R2 is H, C1 -C6 alkyl or C2... | 12/27/1994 |
| 5360805 | Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation Compounds of the formula IV for use as local anaesthetica and analgetica, as well as a method for their preparation, their pharmaceutical preparations and their use. ##STR1##... | 11/01/1994 |
| 5354773 | Use of bafilomycine and derivatives to treat bone diseases A method for the treatment of diseases related to loss of bone mass such as osteoporosis, Paget's disease of bone, hyperparathyroidism, parodontal diseases and implant-related bone loss comprising administration to a patient suffering therefrom an amount ... | 10/11/1994 |
| 5331013 | Method for the treatment of ulcerative proctitis and colitis A method for treatment of ulcerative colitis (and sequelae to surgically treated colitis, for instance ileal pouchiris) and ulcerative proctitis comprising administration to a patient suffering therefrom of a therapeutically effective amount of a local an... | 07/19/1994 |
| 5250411 | Nucleic acid probes specific for Plasmodium vivax and methods of using the same Disclosed are the DNA sequences of probes specific for Plasmodium vivax and the methods by which they were obtained. These nucleic acid sequences proved useful in detection of malaria in man caused by P. vivax by nucleic acid hybridization assays. The hig... | 10/05/1993 |
| 5227389 | Substituted 4-phenyl-4-piperidinecarboxamides with both local anaesthetic and analgesic effect as well as processes for their preparation Compounds of the formula IV for use as local anesthesia and analgesia, as well as a method for their preparation, their pharmaceutical preparations and their use. ##STR1##... | 07/13/1993 |
| 5200551 | Method of preparing an intermediate for the manufacture of bambuterol The present invention relates to an improved method for the preparation of an intermediate for bambuterol, i.e. for the preparation of 2'-bromo-3,5-di[N,N-dimethylcarbamoyloxy]acetophenone (1), by reacting 3,5-dihydroxyacetophenone with N,N-dimethylcarbam... | 04/06/1993 |
| 4990534 | Aralkyl esters and processes for their preparation Aralkyl esters are used to provide a potentiating effect on cholinergic responses.... | 02/05/1991 |
| 3959311 | Oxotremorine antagonists A new class of amino-imide compounds is disclosed in which a 2-oxo-cycloalkylimide group and an amino group are joined by a chain containing acetylenic unsaturation. The compounds are effective to antagonize the tremorogenic effect of oxotremorine and pos... | 05/25/1976 |
